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Copyright of Revista Medica Herediana is the property of Universidad Peruana Cayetano Heredia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Carcinos is the property of Oncosalud S.A.C. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Carcinos is the property of Oncosalud S.A.C. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective. To determine the clinical and histological characteristics and prognostic factors of cervical cancer (CC) in young Peruvian patients. Materials and methods. Retrospective analysis of patients younger than 35 years old diagnosed with CC between 2008 and 2012 in the Instituto Nacional de Enfermedades Neoplásicas. Results. 449 patients had epithelial neoplasms. The main histological types were: squamous cell carcinoma (84.9%), adenocarcinoma (11.0%) and adenosquamous carcinoma (2.4%). The average tumor size was 4.98 cm. Anemia (55.7%), elevated creatinine (21.2%) and hydronephrosis (13.8%) were also identified. 82.3% of the patients presented locally advanced disease. Stages IIB (47.4%) and IIIB (25.8%) were the most common. Overall 5-year survival was 59.5% (I, 90.9%; II, 57.5%; III, 42.7% and IV, 13.3%). Elevated creatinine, anemia, tumor size, parametrial involvement and hydronephrosis were factors that affected survival. No significant relation was found between histological type and survival. The presence of anemia (adjusted hazard ratio [aHR]: 2.5; 95% confidence interval [CI 95%]: 1.6-4.0) and hydronephrosis (aHR: 1.6; CI 95%: 1.0-4.0) were independently associated with survival; likewise, the parametrial commitment with (aHR: 3.3; CI 95%: 1.5-7.2) or without (aRH: 2.6; CI 95%: 1.3-5.3) extension to the pelvic bone. Conclusions. Cervical cancer in young Peruvians is diagnosed in advanced stages. Overall survival in each stage is similar to the reported in older patients. The importance of conventional prognosisrelated factors was confirmed. Anemia was an important independent prognostic factor requiring further investigations. [ABSTRACT FROM AUTHOR]

identificar la expresión de microARNs en pacientes diagnosticados con APCNP, tuberculosis (TB) activa y TB latente en comparación con controles sanos. Métodos: El trabajo siguió el diseño de un estudio mixto: prospectivo (pacientes con APCNP), retrospectivo (pacientes con diagnóstico TB latente y TB activa) y descriptivo. Un total de 14 muestras de suero fueron seleccionadas, de los cuales cuatro fueron controles sanos, tres pacientes con diagnóstico de TB latente, tres pacientes con diagnóstico de TB activa y cuatro pacientes con diagnóstico de APCNP. Se utilizó la metodología RNAseq para el secuenciamiento de ARN total a partir de suero e investigar la expresión diferencial de microARNs. Las librerías fueron analizadas en el secuenciador de próxima generación Hi-seq (Illumina Inc.). El análisis de datos a partir de las corridas de RNA-seq se realizó con programas bioinformáticos que nos permitieron identificar la expresión diferencial de microARNs en cada uno de los grupos analizados. Resultados: Se identificaron marcadas diferencias en la expresión de genes de ARNs presentes en controles sanos, pacientes con TB latente, TB activa y APCNP. Considerando un p-valor < 0.01 se identificaron un total de 2708 genes expresados diferencialmente. En APCNP (1873 genes), TB activa (159 genes) y TB latente (141 genes) fueron expresados diferencialmente en comparación con los controles sanos. Cuando se comparó el APCNP con TB activa y TB latente, se identificaron 275 y 259 genes expresados respectivamente. Así mismo, se identifica 1 solo gen expresado diferencialmente entre TB activa y TB latente. En el análisis de expresión diferencial de microARNs exosomales, se identificaron 3 microARNs específicos para APCNP: miR-200A, miR-485 y miR-7977 que fueron los más sobre-expresados en comparación con los controles sanos. Conclusiones: miR-200, miR-485 y miR- 7977 podrían ser usados como potenciales biomarcadores para el diagnóstico temprano del APCNP en países con alta incidencia de TB como el nuestro. Consideramos necesario realizar estudios adicionales para validar la posible aplicación de estos microARNs exosomales en respuesta al tratamiento y monitoreo de la enfermedad. [ABSTRACT FROM AUTHOR]