1. Uso de pomada de tacrolimus al 0,1% durante un año en niños con vitiligo.
- Author
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Feltes, Rosa, Floristán, Uxúa, Sendagorta, Elena, Ramírez, Paloma, Diez-Sebastian, Jesús, and Laguna, Raúl De Lucas
- Subjects
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VITILIGO , *JUVENILE diseases , *ETIOLOGY of diseases , *TACROLIMUS , *PHOTOTHERAPY , *HORMONE therapy , *ADRENOCORTICAL hormones , *DRUG side effects , *RETROSPECTIVE studies , *THERAPEUTICS - Abstract
Background: Vitiligo is a skin disorder with a predominant autoimmune etiology, characterized by depigmentation of skin and hair. In children, this condition becomes a serious esthetic problem, as well as a therapeutic challenge, due to frequent adverse reactions caused by standard treatments (phototherapy and corticosteroids). Methods: A retrospective study was carried out at the Pediatric Dermatological Unit of La Paz Hospital, with patients treated between 2002 and 2008. Response after one year of treatment with topical tacrolimus 0.1% ointment in 22 young patients (2 to 16 year-old) diagnosed of vitiligo, was assessed. Results: Some degree of repigmentation was observed in 81.8% of patients. A statistical analysis showed that significant response was observed in face, neck and extremities after 9 months of treatment, while in the trunk improvement occurred after 12 months. No related adverse reactions were observed during the treatment period. Conclusion: Tacrolimus ointment could be a good therapeutic option in pediatric patients affected with vitiligo. [ABSTRACT FROM AUTHOR]
- Published
- 2011