Background: Sensitization to mites and cockroach are a common cause of respiratory allergy, especially in children. There is little information about its cross-reactivity with shrimp, which is common in adult patients. Objectives: To determine the frequency of sensitization to house dust mites (Dermatophagoides pteronyssinus, Dermatophagoides farinae) and cockroach species Periplaneta americana, in adult patients attending to a third level hospital and to determine the frequency of sensitization to shrimp in patients with positive skin test to house dust mite and/or cockroach, in patients with clinical manifestations suggestive of allergy to shrimp. Material and method: A retrospective study was done in which results were reviewed of 672 patients clinical records, attending to the Allergy and Clinical Immunology department in a third level hospital, those patients with positive skin test results to Dermatophagoides and/ or Periplaneta americana were investigated for sensitization to shrimp through Prick-to-Prick test. Results: Data from 672 patients were obtained, 69.8% (469) males, with a mean age of 33.5 years. Dermatophagoides positivity was 72.2% (486/672), and its relationship with other invertebrates that also have tropomyosin was 5.6% (4.9% with cockroach and 0.74% with shrimp). Conclusions: In our population, house dust mite sensitization was similar to that reported in the international literature. There was low positivity to cockroach, probably due to geographical conditions. There is very little information about shrimp's cross-reactivity with Dermatophagoides, despite its clinical significance, which requires more specific studies such as measurement of specific IgE to tropomyosin. [ABSTRACT FROM AUTHOR]