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Oral dysbiosis, characterized by an imbalance in the composition of the oral microbiota, has been linked to the initiation and progression of cancer. Dysbiosis induces and exacerbates chronic inflammation that promotes cell proliferation, apoptosis and tumor signaling pathways. In addition, it drives to the indirect metabolism of several substances, including sulfides, nitrosamines, and toxins, which interfere with tumor progression. It also regulates the host immune response, promoting tumor cell survival by interfering with natural killer (NK) cell function. Finally, it influences systemic inflammation and immune dysfunction, contributing to the pathogenesis of various systemic conditions. Furthermore, specific oral bacteria such as Enterococcus faecalis, Fusobacterium nucleatum, and Porphyromonas gingivalis have been related to the progression of oral cancer. These bacteria modulate cellular signaling pathways, immune responses and epithelial-mesenchymal transition in oral cancer cells. Moreover, oral squamous cell carcinoma (OSCC), the most common oral cancer, is influenced by dysbiosis through multiple mechanisms, that include the production of toxins, hormonal imbalance, immune tolerance, and chronic inflammation. Fusobacterium nucleatum, Porphyromonas gingivalis, and Prevotella intermedia have been strongly associated with the development of the OSCC. Understanding the complex interaction between oral dysbiosis and cancer provides insights into potential therapeutic targets and preventive strategies for oral cancer and related diseases. [ABSTRACT FROM AUTHOR]

Copyright of Retos: Nuevas Perspectivas de Educación Física, Deporte y Recreación is the property of Federacion Espanola de Asociaciones de Docentes de Educacion Fisica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: Colorectal cancer is the third most common neoplasm worldwide, and Colombia is no exception. It is essential to study mortality from this condition in specific regions, as variations have been found even within the same country. The objective is to describe the mortality trends from colorectal cancer in the district of Barranquilla between 1985 and 2020. Methodology: A descriptive and retrospective study. Non-fetal death records with colorectal cancer as the underlying cause of death were analyzed from the National Administrative Department of Statistics (DANE) website for residents in Barranquilla between 1985 and 2020. Crude mortality rates were calculated for the years studied, along with the annual percentage changes in these rates. Results: A total of 3,201 deaths from colorectal cancer were recorded, with 59.6% in women and 21.7% in individuals aged 80 years or older. There was an increase in the age-adjusted mortality rate (per 100,000), from 5.1 to 12.7. Overall, there was an upward trend in the annual percentage changes in mortality rates. Conclusion: An increase in colorectal cancer mortality was observed in the district of Barranquilla. It is necessary to continue this line of research and investigate factors related to this trend. [ABSTRACT FROM AUTHOR]

Objective: PI3K is one of the most frequently mutated proteins in cancer, resulting in changes to its functions in regulating metabolism, immunity, among others. Despite the identification of specific drugs targeting PI3K, significant resistance to these therapies has been observed. Therefore, the search for new inhibitors is crucial. This project proposes a strategy based on in silico computational tools for screening Food and Drug Administration (FDA)-approved drugs, aiming to evaluate their potential for drug repositioning. Materials and methods: This study obtained the sequence of PI3Kα from UniProt Knowledgebase and its three-dimensional structure from AlphaFold Protein Structure Database, which were then coupled with adenosine triphosphate (ATP) and its selective inhibitors: inavolisib, taselisib, CH5132799, alpelisib and ZSTK474. Drug-protein interaction analysis was performed using Protein-Ligand Interaction Profiler (PLIP) and its visualization was done in PyMOL. Based on this information, pharmacophores were generated as models for virtual screening using PHARMIT and the FDA-approved drug library (https://pharmit.csb.pitt.edu/search.html). Results: Key atomistic positions of drug-protein interactions were identified based on the selective PI3Kα inhibitors interaction, leading to the generation of nine pharmacophores. A virtual screening resulted in 22 drugs that met the proposed criteria, out of which 10 had binding energy values (kcal/mol) equal to or higher than the PI3Kα inhibitors. Subsequently, three drugs with potential use for drug repositioning were selected. Conclusions: This study proposes fostamatinib, pralatrexate and entecavir as possible candidates for drug repositioning. Additionally, the nine pharmacophores can be utilized in other drug databases for identifying new molecules and/or drugs with potential for drug repositioning. Further in silico and in vitro studies of the proposed drugs are recommended. [ABSTRACT FROM AUTHOR]

Background: Survivors of Intensive Care Units (ICU) frequently experience cognitive impairment, and new or worsened mental health disorders after discharge. Thus, it is necessary to identify the evidence regarding the presence and prevalence of these psychosocial variables in this population that impact their quality of life after discharge. Objective: To identify the most prevalent psychosocial factors in people discharged from the ICU. Method: The search used MeSh and text Word terms, using the booleans "AND" and "NOT" in the PubMed and PsycINFO databases between October and December 2021. Results: 770 articles appeared, of which only 21 were included for review. Most people who stayed in the ICU for >7 days were men between the ages of 40 and 65 and admitted to the ICU primarily for cardiovascular disease. The most reported psychosocial variables are PTSD symptoms (13% to 19%), cognitive impairment (30.2% to 45.3%), anxiety symptoms (28% to 34%), and depression symptoms (24% to 33%), derived from staying in the ICU. Mechanical ventilation, enteral nutrition, prolonged stay, and admission to the ICU more than once, as well as comorbidities, being young, and being women, are risk factors for the presence of these variables in patients admitted to the ICU. Discussion and conclusions: The recommendations support the development of preventive psychotherapeutic interventions at discharge and hospital psychology programs, which mitigate the negative impact at the psychological level, taking into account the type of treatment they received and their social and economic resources. [ABSTRACT FROM AUTHOR]

Pain is a relevant public health problem and is one of the most common symptoms in cancer patients. Identifying psychosocial factors related to cancer pain would allow the development of specific multidisciplinary treatments to mitigate the impact of pain and help improve the patients' quality of life. Objective: To analyze a literature search of psychosocial variables related to cancer pain. Method: A literature search was conducted on publications made between 2016 and 2021 using the PICO strategy within the Pubmed and PsycINFO databases. We revised 22 studies that met the inclusion criteria in full text. Results: Pain intensity is a predictor of quality of life (and its various dimensions) and interferes with various key aspects of daily life. Patients with symptoms of anxiety and depression are more likely to report greater intensity of pain. Likewise, greater intensity of pain relates to lower self-rated health, less social support, more suffering, and greater pain catastrophizing. Conclusion: The identification of psychosocial variables associated with cancer pain requires the establishment of intervention objectives for future research including non-pharmacological treatment for the modulation of pain perception and the improvement in the quality of life of cancer patients in Mexico. [ABSTRACT FROM AUTHOR]

Introduction. Gallbladder cancer is the most common cancer in the biliopancreatic tract and an important cause of mortality. Metaplasia and dysplasia have been mentioned as probable precursors related to the metaplasiadysplasia-cancer sequence. The objective of this study was to establish the possible associations between these histopathological alterations and their relationship with the age and sex of the patients. Methods. Descriptive retrospective observational study, with a cross-sectional analytical component. Pathology reports of patients undergoing elective and outpatient laparoscopic cholecystectomy were included between January 2015 and December 2020, with chronic cholecystitis, cholelithiasis, or gallbladder polyps, over 18 years of age. Demographic characteristics by sex and age was performed using means, standard deviations, and percentages. The chi2 test and Fisher’s exact test were used to evaluate the association between the qualitative variables. Results. 4871 pathology reports were included. In this cohort, a statistically significant association was found between metaplasia, dysplasia, and gallbladder cancer (p<0.05), as well as with the sex and age of the patients. Conclusions. The results suggest an association between metaplasia, dysplasia and gallbladder cancer in the study population. Additional research is recommended to define the possible causality between metaplasia, dysplasia, and gallbladder cancer in a more heterogeneous population. [ABSTRACT FROM AUTHOR]

Copyright of Salud Uninorte is the property of Fundacion Universidad del Norte and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Actualización en Nutrición is the property of Sociedad Argentina de Nutricion and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The ketogenic diet was an amazing approach to treating epilepsy from its beginning. The body undergoes a change in obtaining energy, going from depending on carbohydrates to depending on fats, and then a whole series of biochemical routes are launched that, independently but also complementary, give rise to a set of effects that benefit the patient. This search for its mechanism of action, of devising how to improve compliance and take advantage of it for other diseases has marked its trajectory. This article briefly reviews these aspects, emphasizing the importance of continuing to carry out basic and clinical research so that this treatment can be applied with solid scientific bases. [ABSTRACT FROM AUTHOR]

Copyright of Gaceta Médica de México is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Médica Clínica Las Condes is the property of Editorial Sanchez y Barcelo and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Synthetic hydroxyapatite (sHap) is a biomimetic material with remarkable properties; it is biocompatible and biodegradable, so it is assimilated by the human body. In addition to its known applications in tissue engineering, sHap have shown to be a promising candidate to combat cancer, acting mainly as a matrix for other therapeutic agents. It has a chemical structure with great potential for ionic substitution that increases its characteristics and properties in a sustained, prolonged and targeted manner against cancer. The incorporation of specific elements, such as selenium (Se), helps inhibit the growth and propagation of cancer cells, favors the immune response, and prevents metastasis. This document is a current review of the methods for obtaining sHap and its doping with Se. We discuss aspects of biocompatibility and cytotoxicity, in addition to its documented effect on both healthy and cancer cells. [ABSTRACT FROM AUTHOR]

Objective: To determine the relationship between stigma and mental health in patients diagnosed with cancer. Material and Methods: Correlational study with a non-probabilistic sample of 250 patients diagnosed with cancer, between 26 and 72 years of age (85.2% women and 14.8% men). Data collection was carried out in a private health center using the Perceived, Experienced and Internalized Stigma Questionnaire, the Patient Health Questionnaire-4 (PHQ-4), and a sociodemographic characteristics form. Data analysis was performed using Pearson's correlation coefficient, and the magnitude of the effects was analyzed using the Gignac and Szodorai criteria. Results: Large effect inverse associations were identified between mental health and perceived stigma (r = -0.362), experienced stigma (r = -0.413) and internalized stigma (r = -0.479). Conclusions: The results support that the higher the perceived, experienced, and internalized stigma, the lower the mental health scores of patients with a cancer diagnosis. [ABSTRACT FROM AUTHOR]

Villous adenomas are a type of adenoma with a high potential for malignant transformation, frequent in the colon (rectum, sigmoid and right colon). Generally asymptomatic, they can be hypersecretory causing diarrhea and significant fluid and electrolyte depletion, a condition called McKittrick-Wheelock syndrome. Those of larger size and distal are at greater risk of developing this syndrome. We present the case of a 69-year-old male, with diarrhea for a year, hospitalized for dehydration and electrolyte disturbance. Imaging and complementary studies with a large tumor in the rectum; histopathological result invasive adenocarcinoma with precursor lesion villous adenoma integrating the clinical entity of McKittrick-Wheelock syndrome. [ABSTRACT FROM AUTHOR]

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Copyright of Gaceta Médica de México is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Psicooncologia is the property of Universidad Complutense de Madrid and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Psicooncologia is the property of Universidad Complutense de Madrid and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Revista Nutrición Clínica y Dietética Hospitalaria is the property of Sociedad Espanola de Dietetica y Ciencias de la Alimentacion and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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BACKGROUND: Mucoepidermoid carcinoma is a malignant tumor of the salivary glands. Clinically it appears as an asymptomatic mass that frequently ulcerates. The diagnosis is confirmed by histopathological study. Treatment is mainly surgical, although chemotherapy and radiotherapy can be used as adjuvant or neoadjuvant therapy in high-risk carcinomas. CLINICAL CASE: A 53-year-old female patient arrived at the dermatology department for an ulcerated mass in the oral cavity of three years of duration. A neoplastic process was suspected; therefore, an incisional biopsy was performed which reported a highgrade mucoepidermoid carcinoma. Staging was performed with intravenous contrastenhanced skull tomography, which revealed infiltration of the retromolar trigone and the skull base, T4N0M0 stage was determined. CONCLUSIONS: Mucoepidermoid carcinoma is the most common malignant tumor of the salivary glands. Its behavior varies according to the histological grade, it is imperative that the dermatologist is familiar with rapidly growing neoplasms of the oral cavity since an early diagnosis can be associated with better outcomes. [ABSTRACT FROM AUTHOR]

Introduction: One of the aspects that more interest raises regarding the geographical distribution of mortality due to cancer is the formation of space conglomerates. Objective: To identify the space pattern of mortality due to cancer, ischemic heart disease and ischemic cerebrovascular disease by means of the detection and description of space conglomerates in Santiago de Cuba province. Methods: A space exploratory ecological study of deaths due to cancer, ischemic heart disease and ischemic cerebrovascular disease was carried out during January 1st to December 31, 2019 in Santiago de Cuba province, for which space conglomerates of high and low mortality due to the abovementioned causes were detected. The statistical space escanning method was used with the Satscan program and the independent variables were divided in demographic and clinical. Results: Of the 36 space conglomerates of mortality detected, twenty three corresponded to cancer (65.8%), seven to ischemic heart disease (18.4%) and six to ischemic cerebrovascular disease (15.8%); also, 44.7% of the total was of high risk and 55.3% of low risk. Conclusions: The space distribution pattern of mortality due to prostate, lung, breast, colon, esophagus cancer, ischemic heart disease and ischemic cerebrovascular disease was characterized by the formation of high and low mortality space conglomerates. [ABSTRACT FROM AUTHOR]

Copyright of Revista de Psicoterapia y Psicosomática is the property of Instituto de Estudios Psicosomaticos & Psicoterapia Medica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Nutrición Clínica y Dietética Hospitalaria is the property of Sociedad Espanola de Dietetica y Ciencias de la Alimentacion and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Revista Andaluza de Medicina del Deporte is the property of Centro Andaluza de Medicina del Deporte and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Obesity is a global epidemic. According to the World Health Organization (WHO), it is an abnormal or excessive accumulation of fat that can harm health. Its incidence is increasing alarmingly in developing countries. It is also a significant risk factor for developing chronic diseases such as type 2 diabetes mellitus, arterial hypertension, coronary disease, non-alcoholic fatty liver disease, and musculoskeletal disorders such as osteoarthritis. Furthermore, associations have been found between obesity and the development of prostate, liver, gallbladder, kidney, colon, endometrial, breast, and ovarian cancer. Bariatric and metabolic surgery is the most effective treatment for morbid obesity and its comorbidities. This surgery can reduce general mortality by 40% at ten years due to cardiovascular outcomes, diabetes, or cancer and improve metabolic diseases such as type 2 diabetes. [ABSTRACT FROM AUTHOR]

Cancer survivors must adapt in many cases to sequelae and limitations that produce emotional distress and stress daily. Social support can help reduce this discomfort, but the effects of how often it is received still need to be determined or whether its absence produces adverse effects. The present study evaluated the daily discomfort of 60 cancer survivors, using daily recordings, the stress experienced, and the social support received. The results indicate that receiving social support reduces discomfort in the short term but seems less effective when the patient attributes the cause of discomfort to being a survivor. The reduction in discomfort, however, is not sustained in the long term. These results suggest that the survivor should receive help to cope with daily discomfort and their social environment to understand better its causes to provide more effective support. [ABSTRACT FROM AUTHOR]

Depression stands out as the most prevalent psychiatric condition in the field of oncology. The diagnosis or potential diagnosis of cancer significantly affects the mental well-being of both patients and their family members, given the profound impact the disease attributes to the individual's new state of health. The article aims to provide and updated understanding of the current knowledge regarding the epidemiology, etiology, pathogenesis, diagnostic tools, and treatment concerning the intricate relationship between cancer and the development of depressive disorders. To achieve this objective, a comprehensive bibliographic search was carried out using the keywords depression, cancer, and the AND command for the term depression and cancer across PubMed, Scopus, SciELO, and Google Scholar databases. The search spanned multiple languages, including Spanish, English, and French, covering the period from 2010 to 2023. A total of 55 articles, selected by the authors for their relevance to the review's objective, were included. The review revealed a clear association between cancer and the development of major depressive disorder, was evidenced with a high prevalence rate of at least 40%. This association is attributed to a complex interplay of genetic, epigenetic, and environmental factors. Various validated tools, such as the Hospital Anxiety and Depression Scale (HADS), the Beck Depression Scale and the Montgomery-Åsberg Depression Rating Scale (MADRS) have been employed to assess depression in cancer patients. In conclusion, once a diagnosis of depressive disorder is confirmed within the oncology population, a combination of pharmacotherapy and/or psychotherapy is recommended. This approach, not only aims to enhance the quality of life for patients but also plays a crucial role in preventing treatment noncompliance and increasing overall survival rates. [ABSTRACT FROM AUTHOR]

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Copyright of Psicooncologia is the property of Universidad Complutense de Madrid and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Psicooncologia is the property of Universidad Complutense de Madrid and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Vulvar cancer represents only 1% of cancers in women, being malignant melanoma the least frequent within this type of cancer. It occurs in older women. Its management is mainly surgical and has a high mortality mainly due to metastatic disease. We present the case of a woman who arrived with a mass in the labia majora and was diagnosed as vulvar malignant melanoma, treated with surgery and radiotherapy in a timely manner, but who presents pulmonary metastasis, who is currently receiving treatment for this. [ABSTRACT FROM AUTHOR]

Introduction: chemotherapeutic drugs have an ototoxic component that can cause balance disturbances that trigger fractures. The case exposes the development of a Physiotherapy intervention in cancer patients through vestibular exercises of an individual with a hip fracture after a fall. Case presentation: eighty-year-old male with femur fracture surgery due to imbalance after chemotherapeutic ototoxicity. Pre and post intervention (between November and February 2022) evaluation of vestibular assessment parameters and specific functional tests (Time Up and Go Test, Dizziness Handicap Inventory, Clinical Test of Sensory Interaction and Kinesiophobia Test) were carried out after four sessions in seven weeks of vestibular physiotherapy. Results: after the intervention we obtain better results in all the parameters, insisting a lot on the adherence of the patients to the sessions. The high score for Kinesiophobia is maintained due to fear of movement. [ABSTRACT FROM AUTHOR]

Copyright of INSPILIP. Revista Ecuatoriana de Ciencia, Tecnología e Innovacion en Salud Pública is the property of Instituto Nacional de Investigacion en Salud Publica (INSPI) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Breast cancer is the most frequent malignant tumor in women, approximately 5 to 10% is due to inherited genetic mutations (BRCA1 and BRCA2) which generates its appearance before menopause, debuting as mammary lesions that simulate benignity generating false negatives, that is the reason of the importance of the patient's clinical history and the support of imaging studies as well as taking a biopsy for its definitive diagnosis, as it is shown in the following article. [ABSTRACT FROM AUTHOR]

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Copyright of Agricultura Sociedad y Desarrollo is the property of Colegio de Postgraduados and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)