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Background and objective. Multiple mastopexy techniques have been described, however, reports of long-term results in different techniques are scarce. The inverted-T and periaerolar techniques continue to be the most used, reason why we describe our experience with the long-term comparison of the two techniques. Methods. A longitudinal, comparative, observational, retrospective study comparing aesthetic satisfaction, speed of recovery and the probability of long-term associated complications was carried out in 97 mastopexy cases: 48 operated with the inverted-T technique and 49 with the periareolar technique. The homogenization of the data was analyzed with the x² and Fisher tests and the odds ratio (OR, 95% CI) was used as a measure of association between the surgical technique used and the probability of presenting complications. Results. At 5 years, of 48 patients who declared satisfaction of 100-80% all were operated with the inverted-T technique (p <0.001). For both the inverted T technique and the periareolar technique, the p-value according to the Friedman test for related samples was <0.000. Conclusions. In our experience, the periareolar mastopexy pattern has less satisfaction and more long-term complications than the inverted-T technique, from which we conclude that the periareolar mastopexy pattern is recommended in patients with grade I mammary ptosis and/or with small volume breast implants; mastopexy with the inverted-T technique has more satisfaction and fewer long-term complications like widening of the nipple-areola complex and breast asymmetry. [ABSTRACT FROM AUTHOR]

Background and Objective. The internal nasal valve (INV) is located in the middle third of the nose where the upper lateral cartilages join the nasal septum. Sometimes, the upper lateral cartilage collapses and causes ventilatory difficulty and aesthetic nonconformity. Our aim is to associate tomographic variables with sensation of aesthetic and ventilatory improvement, 3 months after using spreader-grafts. Methods. Longitudinal study of patients with simultaneous nasal aesthetic non conformity and ventilation difficulty that undergo rhinoplasty with spreader-graft collocation, and description of some surgical examples. Bone-based CT determines preoperative and 3 months postoperative angles of the INV; subjective aesthetic and/or ventilatory improvement is recorded clinically too. A comparative analysis was carried out, testing for the homogeneity of the sample data: Chi-squared test for pre and postoperative angles, as well as for spreader-graft diameter; binomial test for "V" deformity; Kolmogorov-Smirnov for age. In order to associate each independent variable with aesthetic and ventilatory improvement, RR (CI 95%), PPV and NPV were calculated. Results. Sample with 61 patients. Spreader-graft diameter: >4mm (27.9%), RR ventilatory improvement 1.43 (IC al 95%, 1.12 -1.82); 2-4mm (44.3%); 2mm (27.9%). Preoperative valve angle: 15-10° (16.4%); 10- 5° (50.8%); <5° (32.8%). Postoperative valve angle: 10° (44.3%); 10-15° (47.5%); >15° (8.2%). With (63.9%) or without (36.1%) inverted "V" nasal deformity. Aesthetic and ventilatory improvement (60.7%), isolated aesthetic improvement (11.5%), isolated ventilatory improvement (13.1%), no improvement at all (14.8%). Conclusions. Spreader-graft >4 mm has a statistically significant association with ventilatory improvement, along with variable clinical significance; 15-10° preoperative valve angle is associated as well with aesthetic and ventilatory improvement. [ABSTRACT FROM AUTHOR]

Baclofen is a GABA-B agonist drug used to treat mainly spasticity but it has shown some possible analgesic properties. The baclofen induced antinociception by GABA agonists depressing the central nervous system by decreasing the release of glutamate and aspartate. Objectives: Determine the antinociception effect of Baclofen after it administration in a model of neuropathic pain in rats. Material and methods: Thirty male albino rats of Wistar strain, weighing between 150 and 250 grams were used. Rats were prepared for surgery and anesthetized with intraperitoneal chloral hydrate. Right sciatic nerve was isolated and injured by constriction. Baclofen was applied in different doses (1, 4, 6 mg/kg) intra-peritoneal according to the experimental groups. The rats were subjected to a battery of various pain tests. Each test was performed on both hind legs. Repetitive ANOVA test was used and the p < 0.05 was significant. Results: Pain measurement with Von Frey filaments of the left leg was 1.13 (± 0.32) mm as a base line in all groups, compared with the right leg that was1.04 (± 0.36) mm as the same condition. Significant differences were obtained after baclofen application in all the groups. Altered gait percentages in each group was remarkable in group A, and was ameliorate in group B, C, and D (p < 0.001) and normal in group E. Autotomy, edema and leg retraction was observed like complications main in group C (20%) and D (40%). Conclusions: Baclofen demonstrated as an excellent antinociception drug to treat neuropathic pain in rats, and was dose-dependent. [ABSTRACT FROM AUTHOR]