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Dapsone was discovered in 1908, it is a drug prescribed in inflammatory and infectious diseases. It is the first line treatment mainly in skin diseases with an accumulation of neutrophils and eosinophils. It is metabolized by two enzymatic pathways N-acetylation and N-hydroxylation. It has adverse haematological, skin, gastrointestinal, kidney and nervous system effects. [ABSTRACT FROM AUTHOR]

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BACKGROUND: The relationship between dermatological and psychiatric disease has been demonstrated. OBJECTIVES: To identify the presence of associations between self-reported dermatological complains and self-reported symptoms associated to depression, anxiety and stress during COVID-19 pandemic by an online survey. MATERIALS AND METHODS: Observational study with an online questionnaire was made. The questionnaire included demographic data, DASS-21 scale and Dalgar questionnaire. RESULTS: 1042 surveys were analyzed: the frequency of self-reported dermatological complains in the population was obtained as well as the frequency of depressive, anxious and stress-related symptoms in their different degrees. Associations were found between depressive, anxious and stress-related symptoms with itchy skin (OR = 1.740, 95%CI: 1.749-4.098), dry/sore rash (OR = 2.962 95%CI: 1.659-5.288), scaly skin (OR = 2-562, 95%CI: 1.490-4.406), itchy rash on the hands (OR = 1.963, 95%CI: 1.164-3.313), "pimples" (OR = 4.186, 95%CI: 2.865-6.116), other rashes on the face (OR = 3.349, 95%CI: 1.738-6.806), troublesome sweating (OR = 3.316, 95%CI: 2.946-5.374), loss of hair (OR = 2.835, 95%CI: 2.021-3.977) and other skin problems (OR = 3.406, 95%CI: 1.351-8.588). CONCLUSIONS: Symptoms related to depression, anxiety and stress are associated with the presence of dermatological complaints. RESULTS: 1042 surveys were analyzed: the frequency of self-reported dermatological complains in the population was obtained as well as the frequency of depressive, anxious and stress-related symptoms in their different degrees. Associations were found between depressive, anxious and stress-related symptoms with itchy skin (OR = 1.740, 95%CI: 1.749-4.098), dry/sore rash (OR = 2.962 95%CI: 1.659-5.288), scaly skin (OR = 2-562, 95%CI: 1.490-4.406), itchy rash on the hands (OR = 1.963, 95%CI: 1.164-3.313), "pimples" (OR = 4.186, 95%CI: 2.865-6.116), other rashes on the face (OR = 3.349, 95%CI: 1.738-6.806), troublesome sweating (OR = 3.316, 95%CI: 2.946-5.374), loss of hair (OR = 2.835, 95%CI: 2.021-3.977) and other skin problems (OR = 3.406, 95%CI: 1.351-8.588). CONCLUSIONS: Symptoms related to depression, anxiety and stress are associated with the presence of dermatological complaints. [ABSTRACT FROM AUTHOR]

BACKGROUND: COVID-19 caused by SARS-CoV-2 was first described in December 2019 in Wuhan, China, declared as a pandemic by the WHO since March 11, 2020. The most common presenting symptoms are cough, fever, dyspnea and myalgia; however, every day cases are described where the patient debuts with atypical symptoms. CLINICAL CASE: A 54-year-old male patient with COVID-19 whose initial symptom was singultus (hiccups). CONCLUSIONS: Persistent hiccups is an atypical presentation of pneumonia, especially in elderly patients. Despite the fact that hiccups has many possible etiologies, due to COVID-19 pandemic and its most common manifestation being atypical pneumonia, any patient who develops persistent singultus should be further studied to ruled out SARS-CoV-2 infection. This could identify early cases of COVID-19, decreasing the contagion rate and increasing prognosis. [ABSTRACT FROM AUTHOR]

Copyright of Medicina (Buenos Aires) is the property of Medicina (Buenos Aires) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Actualizaciones en Osteología is the property of Asociacion Argentina de Osteologia y Metabolismo Mineral and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Actualizaciones en Osteología is the property of Asociacion Argentina de Osteologia y Metabolismo Mineral and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Topical minoxidil is a drug commonly prescribed as a treatment of different types of alopecias. Its mechanism of action is poorly understood; however, it is recognized that prolongs anagen phase, reduces telogen phase and increases the thickness of the miniaturized follicles; besides to intensifying the expression of vascular endothelial growth factor (VEGF) and being a potassium channels regulator. Hypertrichosis is the increase of body hair above the normal variation of a population group, considering individuals of the same age, race and sex. It has been reported as a secondary side effect after the use of minoxidil in children. Possible causes are an increased systemic absorption and a greater sensitivity of the hair follicle to the concentration in which the drug is administered. This paper reports the case of an 8-year-old female with a diagnosis of hypertrichosis secondary to the use of topical minoxidil. The main treatment is the immediate suspension of the drug. Special caution should be exercised with the use of topical minoxidil in pediatric patients. [ABSTRACT FROM AUTHOR]

Existen pocos resultados empíricos que orienten al clínico en la elección de un antidepresivo entre la amplia gama de fármacos disponibles. Dada la ausencia de estudios empíricos confirmados que faciliten dicha elección, resulta interesante analizar los factores que tienen en cuenta los psiquiatras al prescribir un antidepresivo. Método: Los psiquiatras responsables de 1. 137 pacientes con depresión a los que habían recetado un nuevo antidepresivo rellenaron un cuestionario de 43 ítems que reflejaban los factores que podrían haber determinado su elección. El cuestionario fue completado inmediatamente después de prescribirse el fármaco para tratar el trastorno depresivo. Resultados: Los factores que condicionaron en mayor medida la elección de un antidepresivo fueron el deseo de evitar determinadas reacciones adversas, la presencia de factores psiquiátricos conmórbidas y de determinados síntomas clínicos y los antecedentes terapéuticos, incluida la respuesta anterior, positiva o negativa, a un fármaco. Algunos factores analizados exhaustivamente por la bibliografía, como el síndrome de retirada del fármaco y las interacciones farmacológicas, apenas influyeron en la elección del antidepresivo. Conclusiones: Dado que son relativamente pocos los estudios que han examinado las características clínicas y su relación con la respuesta diferencial a los antidepresivos de nueva generación, un estudio que examina los hábitos de prescripción de los psiquiatras destaca algunos aspectos prioritarios para las futuras investigaciones controladas. Nuestros resultados señalan dos áreas de especial relevancia, el tratamiento de la depresión con síntomas o trastornos de ansiedad comórbidos y la influencia de determinados síntomas sobre la respuesta farmacológica. [ABSTRACT FROM PUBLISHER]