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Introduction: Gastric cancer is one of the most common causes of death worldwide, with a varying incidence. In Ecuador, it is the second leading cause of death in men and the fourth in women. Objectives: To establish the socio-demographic, clinical, histological, and endoscopic characteristics of patients with gastric cancer and to determine the correlation between location and histology in this population treated at the Hospital de Especialidades Guayaquil Dr. Abel Gilbert Pontón. Materials and methods: Analytical and prospective prevalence study. Outpatient and emergency upper gastrointestinal endoscopies with signs of suspected gastric cancer performed at the Hospital de Especialidades Guayaquil Dr. Abel Gilbert Pontón - Ecuador between January 2018 through December 2019 were included. Results: The study included 62 patients diagnosed with gastric adenocarcinoma. 72.6% were male and 27.4% were female; the age range was between 27 and 95 years, with an average of 60.96 ± 15.1 years, the age of onset being between 60 and 70 years. Pain was the most frequent symptom in 98.4% of cases, followed by weight loss in 64.5%. The antrum was the most common site of cancer (50.0%), and Borrmann type III was the most common morphology. Intestinal cancer was found in 64.5% of cases, while diffuse gastric cancer was found in 29.0%. Intestinal cancer was more common in older ages (60-69%) and the most frequent site of presentation was the body of the stomach (71.4%) with a proximal location. In contrast, diffuse gastric cancer was more frequent in younger patients aged between 27-39 years, more often in the antrum (32.3%) at a more distal location. Conclusions: Gastric cancer is more often found in men and is usually diagnosed in advanced stages. Intestinal gastric cancer was most commonly seen at advanced ages in our hospital, most frequently at the proximal site and in the Borrmann type III according to the classification of advanced gastric cancer, affecting its treatment and prognosis. The results obtained support the implementation of programs to diagnose and treat this severe disease in a timely manner. [ABSTRACT FROM AUTHOR]

Paraneoplastic pemphigus, an acquired autoimmune mucocutaneous condition of the skin and mucous membranes, is characterized by erythema and painful blistering, concomitant with underlying neoplastic disease. Clinical manifestations may precede, occur concomitantly or present after cancer diagnosis. Specific associated neoplasms are usually hematologic (non- Hodgkin's lymphoma, chronic lymphocytic leukemia, Castleman's disease, thymoma, Waldenström macroglobulinemia), less frequently sarcomas. We present the case of a patient with paraneoplastic pemphigus in whom the clinical presentation preceded the diagnosis of gastric adenocarcinoma. In the medical literature few cases are associated with gastrointestinal neoplasms. [ABSTRACT FROM AUTHOR]

Paraneoplastic pemphigus, an acquired autoimmune mucocutaneous condition of the skin and mucous membranes, is characterized by erythema and painful blistering, concomitant with underlying neoplastic disease. Clinical manifestations may precede, occur concomitantly or present after cancer diagnosis. Specific associated neoplasms are usually hematologic (non- Hodgkin's lymphoma, chronic lymphocytic leukemia, Castleman's disease, thymoma, Waldenström macroglobulinemia), less frequently sarcomas. We present the case of a patient with paraneoplastic pemphigus in whom the clinical presentation preceded the diagnosis of gastric adenocarcinoma. In the medical literature few cases are associated with gastrointestinal neoplasms. [ABSTRACT FROM AUTHOR]

A descriptive and retrospective study of 989 patients with endoscopic diagnosis of chronic gastritis whose biopsies had been processed in the Pathology Department of Palma Soriano in Santiago de Cuba, was carried out during 2008-2014, aimed at determining the incidence of the infection due to Helicobacter pylori, for which the variables: age, sex, gastritis types, presence of the organism and its association with malignancies were also considered. In the series the 40-49 years age group (26,7 %) and female sex (69,0 %) prevailed; also, the superficial gastritis was more frequent (57,8 %) and the bacteria was found in 70,5 % of the sample, where only 0,5 was associated to malignancies. [ABSTRACT FROM AUTHOR]

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Copyright of Galicia Clínica is the property of Sociedad Gallega de Medicina Interna and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This is the case of an adult labrador retriever dog with nonspecific signs that compromised its gastrointestinal system. After performing complementary tests, grave alterations of the liver were found. A treatment was begun, but given the systemic compromise of the patient and its poor prognosis, euthanasia was the chosen alternative. In the necropsy, a mass in the lesser curve of the stomach was found, and it compromised the whole wall of this organ. Besides, macroscopic changes in the liver, the omentum, the lymph nodes, the lungs and the diaphragm were observed. In the histopathology test results a diagnosis of gastric adenocarcinoma with liver and lung metastases was achieved. [ABSTRACT FROM AUTHOR]

Copyright of Revista Española de Patología is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Gastric cancer is the most common malignancy of the digestive tract worldwide. Adenocarcinoma accounts for 90%-95% of all malignancies of the stomach. There have been studies on the expression of Her-2/neu in cancer of the stomach. Several studies showed that overall survival and time of occurrence of relapses in patients with these neoplasms was lower in those who had higher levels of this oncogene, suggesting that Her-2/neu could be used as a prognostic factor. Increased expression of Her-2/neu and its accessibility make this receptor a suitable target for direct anti-tumor therapy. Objectives: To assess the expression of Her2/neu in gastric adenocarcinomas. Material and methods: observational, analytical and retrospective study in which we observe the expression of Her-2/neu, were studied in 65 total gastrectomy with a diagnosis of adenocarcinoma, were selected paraffin blocks, to which they were performed with hematoxylin staining and eosin and immunohistochemistry. Results: The immunohistochemical reaction produced by the Her2/neu antibody was positive in only six cases (9.23%), and negative in 59 cases (90.76%). Four (66.66%) were found in body and antrum. It was observed that the expression of Her2/neu is related to the degree of infiltration in four cases (66.66%) was observed in the serous infiltration, and in the remaining two (33.33%) a muscle. Conclusion: We found a low prevalence (9.23%) of the expression of Her2/neu, the figures are within international standards. [ABSTRACT FROM AUTHOR]

We present the case of an adult woman with cardiac tamponade and death associated to pericardial metastasis from a diffuse gastric adenocarcinoma that lacked gastrointestinal clinical manifestations. These diagnoses were not established until post-mortem pathological examination. The clinical differential diagnoses with an autoimmune disease as well as pitfalls in the cytological diagnosis dealing with pericardial effusion material are discussed. Cardiac tamponade due to pericardial metastases from gastrointestinal cancers are exceptional events hardly ever diagnosed in clinical practice. [ABSTRACT FROM AUTHOR]

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Copyright of Clinical & Translational Oncology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)