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Alzheimer's disease is a neurological disorder that causes loss of autonomy and memory in people who suffer from it. Due to the increase in cases of this disease and the lack of accuracy of diagnostic tools, new tools capable of addressing this issue are being developed. The main objective of this research work is to implement a three-dimensional convolutional neural network model with AlexNet3D type base structure to predict the possible diagnosis of Alzheimer's disease (AD). from the analysis of magnetic resonance images, using as an early stage mild cognitive impairment syndrome (MCI). The construction phases of the project will be explained, divided into database selection, feature selection, data processing, model development for training and validation, and finally, results obtained from prediction tests. With this it was possible to obtain a percentage of 72,222 %, allowing the K-Net95 model to be cataloged as a stable and efficient network, despite the computational limitations to which the project was limited. [ABSTRACT FROM AUTHOR]

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The present work analyzes the repercussion of the nontoxic engraving technique Collagraph, in people with Early Alzheimer's Dementia, in the artistic education program "Retales de una vida". The objective is to connect the participants with programs of a cultural nature to encourage communication and interaction between participants. The experience was carried out at the State Reference Center for people with Alzheimer's and other Dementias of Salamanca (CREA). Once the methodology of the workshop has been adapted to the personal and health characteristics of people with Alzheimer's disease, it is considered that the use of engraving generates important benefits in the participants, related to the increase in crystallized intelligence, prosocial behavior and positive assessment. of themselves, favoring social and family inclusion. Likewise, the use of engraving can offer support for individual and cooperative therapeutic help to the participants, develop functional, social and cognitive skills, expanding their emotional resources and enjoying the experience. In turn, they strengthen their self-esteem and security in the face of their ability and worth. Finally, we propose a series of guidelines for the planning and implementation of this artistic process so that it serves as a reference for health professionals. [ABSTRACT FROM AUTHOR]

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The use of computer-aided devices and systems in the field of health has become quite widespread. These devices and systems contributed to faster and earlier diagnosis of diseases. Especially imaging devices such as Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) play a major role in diseases where early diagnosis is important. In neurological diseases, the use of MRI and CT images as input images in deep learning models is becoming increasingly common. In this study, MRI images from the "Alzheimer's Parkinson's 3 Class Data Set" dataset obtained from the Kaggle website were used to diagnose Alzheimer's and Parkinson's diseases. There are three classes in this data set: 2561 Alzheimer's, 906 Parkinson's and 3010 Control (Normal). In this study, when Alzheimer's Parkinson's and Normal classes were trained with ResNet-18, VGG-16 and ConvNext architecture, accuracy rates of 96.2%, 95.4% and 98.9% were obtained respectively. In addition, Alzheimer's and Parkinson's diseases were tested with binary classifiers on the normal class. Among the models trained for Alzheimer's - Normal and Parkinson's - Normal classes, ResNet-18 architecture achieved 82.0% and 96.1%, VGG- 16 architecture achieved 95.4% and 89.4%, and ConvNext architecture achieved 99.4% and 99.5% success rates, respectively. [ABSTRACT FROM AUTHOR]

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Copyright of Retos: Nuevas Perspectivas de Educación Física, Deporte y Recreación is the property of Federacion Espanola de Asociaciones de Docentes de Educacion Fisica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Revista de Investigación en Musicoterapia is the property of Revista de Investigacion en Musicoterapia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Gerokomos is the property of Indemm Farma SL and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Quantitative studies about linguistic aspects of Alzheimer's disease have been more abundant when compared to studies from a qualitative viewpoint. Thus, this article propounds applying the linking algorithm shown in Role and Reference Grammar and its application to the PerLA corpus of Spanish patients with Alzheimer's with the aim of identifying the linguistic deficits encountered in the first stage of the disease. This will allow us to show first results on the application of this grammar to corpora and to prove its feasibility in a better description of Alzheimer's disease. These results point to unfinished sentences and clauses, irregular syntax and the prevalence of communicative intention. Although we have analyzed a very small sample, results show that this grammar may be useful in describing language production and comprehension more precisely regarding this disease. [ABSTRACT FROM AUTHOR]

Objective: Conduct a systematic review of therapeutic development strategies for Alzheimer’s disease and schizophrenia based on positive allosteric modulation of the M1 receptor. Method: A systematic review of articles on Pubmed, Ebsco and Science Direct was carried out, from 2015, following established guidelines for selecting keywords, inclusion and exclusion criteria Results: A total of 44 articles met the established criteria, 20 of them are reviews and 11 are publications where one or more compounds are synthesized and pharmacologically evaluated. Half of the publications that conduct an in vivo evaluation are in publications of the Center for the Discovery of Drugs in Neurosciences of Vanderbilt University. Its main discovery, the compound VU0486846, is the newest and most important derivative result of a line of therapeutic advances based on the allosteric activation of the M1 receptor, which has no direct agonist activity on muscarinic receptors but if can positively modulate the activity of acetylcholine on the M1 receptor, demonstrating absence of severe cholinergic adverse effects in animal models. Searching for molecule derivatives with higher property balance does not provide a better candidate. Conclusions: The development of compound VU0486846 corresponds to an important milestone in the search for treatments for Alzheimer’s disease and schizophrenia. The success of this molecule and its research route is a validation of the pharmacological importance of allosteric modulation in the search for new pharmacological targets. [ABSTRACT FROM AUTHOR]

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Copyright of Revista Científica Facultad de Ciencias Químicas y Farmacia is the property of Facultad de Ciencias Quimicas y Farmacia de la USAC and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Between Alzheimer's Disease (AD) and Diabetes Mellitus (DM) it has been evidenced that there are multiple mechanisms in common in both pathologies, ranging from cognitive deterioration in the clinical aspect to biochemical alterations of which the following can be highlighted; the increase in pro-inflammatory agents and excitotoxicity, increase in oxidative stress and increase in the final products of advanced glycation (AGEs), alterations in glucose metabolism, as well as alterations in the mTORC1 /S6 and GSK-3 pathways ß; It also highlights the role of Insulin Resistance (Ri), where this alteration is linked to both AD and MD at various points in their physiopathology, either by influencing the different mechanisms mentioned above or directly. Objective. It is described how the influence of this hormone is such, whether its levels are high, effect known as hyperinsulinism or low effect known as hypoinsulinism, since both extremes lead to neurodegenerative effects characteristic of AD, mainly in the increase of ß amyloid (Aß) and hyperphosphorylated tau (pTau), through different processes. Contribution. We describe this phenomenon as "The insulin paradox", in which the insulin/PI3K/Akt pathway also stands out as a crucial point, since independently of hyper or hypoinsulinism conditions this pathway is altered in both scenarios. This relationship between AD and DM is considered from the point of view of hypoglycemic treatments aimed at the attention of DM, which seem to interfere with AD, through several of the mechanisms in common that these pathologies have. Conclusion. Although it is too early to consider that these treatments for AD will give the same results in cases of AD, these data are valuable precedents in the search for therapeutic alternatives for AD. [ABSTRACT FROM AUTHOR]

Neurocognitive impairment and aging are associated with atrophy of the gray matter, mesial and posterior cortical predominance in Alzheimer disease (AD). There are also alterations in the white matter. This study correlates the hippocampal volume with values of factional anisotropy, as a sign of degeneration in the white matter in 3 groups of patients, with AD, mild cognitive impairment (MCI) and controls. Results: The volume of the right hippocampus had a mean of 2.126cc (0.727 standard deviation [SD]) for the AD group, 2.804cc (0.467 SD) for the MCI group, and 3.932cc (0.961 SD) for the control group. The volume of the left hippocampus was 2.274cc (0.48 SD) for the AD group, 2.728cc (0.653 SD) for the MCI group, and 3.807cc (0.867 SD) for the control group. Correlation between hippocampal volume and fractional anisotropy (FA) values in the anterior temporal regions, splenium and posterior cingulate was demonstrated. Conclusion: There is a strong correlation of the hippocampal volume and a decrease in FA of the anterior temporal regions, posterior cingulate and splenius of the corpus callosum. This demonstrates association of leukopathy and decreased cortical volume, with the degree of neurocognitive impairment. [ABSTRACT FROM AUTHOR]

This critical approach to pictures books focuses on the use of humour to transmit transcendental themes as such as Alzheimer's disease to children readers. Positive Psychology investigates how to improve the quality of people's life. Picture books are analysed as a tool that helps to inform children readers about Alzheimer's disease without too much pain. Both rhetorical and iconic resources that are used to defuse a complicated situation through humour are analysed by this work. A comparative study of two dissimilar works is realised. Specifically, both discourse analysis and illustration analysis are utilized. The comparative analysis between El zorro que perdió la memoria and El atardecer makes possible the study of humorous resources on picture books that were designed for children readers. First work is a traditional fable in which animals have the leading role. And, also, author's tones are plentiful and make possible humoristic discourse. The literary and plastic quality of both works stands out among on the current didacticism that offer moral values on literature. Humour appears on the text (metaphors, pun, hyperboles), on the font, on the paratext, and especially on the illustrations with clear de-dramatized function. [ABSTRACT FROM AUTHOR]

Copyright of Cirugía y Cirujanos is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Signos is the property of Pontificia Universidad Catolica de Valparaiso and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The prevalence of memory disorders in adulthood requires sensitive, specific and quick administration screenings instruments for the detection of cognitive impairment. Objective: To establish the validation of EDO, a brief questionnaire to be completed by the patient's informant, which serves to detect subjects with mild cognitive impairment. It is an instrument that can be administered in a simple manner and has the advantage of not needing the presence of the patient. The questionnaire has 10 quick response questions to be used in the clinic. Methods: 44 patients with mild cognitive impairment and 40 normal controls matched by age and educational level were evaluated with EDO and with an extensive Neuropsychological Battery. Results: Groups differed significantly in the EDO, MMSE (p <.001), CDR (p <.001) and RAVLT (p <.001). The EDO showed a significant correlation with the CDR (r = .524, p < .001), with RAVLT (r = -.551, p < .001) and with the FAQ (r = .705; p < .001). The area under the ROC curve was 0.835 and a cut-off score of 4 had a sensitivity of 0.75 and specificity of 0.78 to detect mild cognitive impairment. Conclusions: EDO is a fast and easy administration instrument with adequate psychometric properties to be used in MCI detection. [ABSTRACT FROM AUTHOR]

Introduction: Alzheimer disease is presented with different neuropsychological phenotypes and it is considered that the memory disorder is its most important one; however, recent studies suggest that the dysfunctions in the executive functions can constitute very early markers of the disease. Objectives: To characterize the clinical and neuropsychological profiles that constitutes phenotypical markers of the neurocognitive disorders possible Alzheimer subtype. Methods: A descriptive and cross-sectional study of 39 sick persons with ages between 57-85 years, classified according to the DSM-5 criteria, with cognitive mild and major disorder, classified from the etiological point of view in the possible Alzheimer subtype was carried out. Multiple cognitive domains were evaluated (complex attention, memory and learning, executive functions, language, motor and perceptual functions) and a detailed evaluation of the executive functions was made by means of a group of specific neuropsychological tests. Results: The statistical analysis demonstrated that comparing the two study groups with cognitive disorder, significant differences exist as for the level of cognitive performance in all the explored domains, except in the perception and motor functions. Likewise, the results demonstrated that the yielding level for each function evaluated within the domain of the executive functions is significantly different between both groups with cognitive disorder, except for the space orientation. Conclusions: The neuropsychological profile of the cognitive disorder Alzheimer possible subtype was characterized by a disorder in multiple domains, with predominance of the focused executive dysfunction in the areas of the mental flexibility and inhibition of automatisms. [ABSTRACT FROM AUTHOR]

Caring for a person with Alzheimer's has been identified as a highly stressful task for the informal caregiver. The coping strategies allow modulating the emotional impact of this task. The purpose of this paper is to describe the coping strategies most commonly used by informal caregivers of people with Alzheimer's and to identify if there are differences in the use of these according to personal and-or situational variables. 57 informal caregivers of people with Alzheimer's from a rural association in Castilla y León (Spain) have participated. The different use of strategies is related in different ways to the variables studied. There is no uniform response pattern. The study confirms the idea of flexible coping. The results reveal the need for training in the flexible and adaptive management of these strategies according to personal traits and the specific demands of the situation. [ABSTRACT FROM AUTHOR]

Due to their characteristics, Alzheimer's dementia (AD) and fronto-temporal dementia (FTD) coincide, from a psychosocial perspective, in the direct and significant impact on the members of the social environment of those who experience them. Objective: to identify and describe the role of social support networks from the information available in the literature, emphasizing the caregiver and considering in them the processes of social cognition, only from conceptual analysis and empirical evidence available from previous research on these two types of dementia. Method: documentary and systematic review of investigations from specialized databases. Results: there were differences in the level of impact that both types of dementia have on the social support network, including the caregiver, depending on the type of dementia and on the availability of resources by the network. Likewise, it was observed that there is a documentary gap in the analysis about the participation of social cognition in the relationship between the members of the network and those suffering from any of these dementias. From this study, arise questions that suggest further description of these types of dementia should be made. [ABSTRACT FROM AUTHOR]

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Copyright of Dilemas Contemporáneos: Educación, Política y Valores is the property of Dilemas Contemporaneos: Educacion, Politica y Valores and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Ensayos: Revista de la Facultad de Educacion de Albacete is the property of Ensayos Revista de la Facultad de Educacion de Albacete and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Desacatos is the property of Centro de Investigaciones y Estudios Superiores en Antropologia Social and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Dementia is an acquired syndrome, of an organic nature, characterized by a permanent deterioration of memory and other cognitive functions and often accompanied by other psychopathological manifestations. Its importance is that it is expected that the number of adults with Alzheimer's will increase in the coming years and at least 50% by 2030. Therefore, physicians will be confronted with a large number of patients with this complex syndrome, which should make us turn on the alarms to make great efforts in therapeutics and to be aware of the multiple details of this syndrome. In this chapter we describe the different types of dementia, including Alzheimer's disease, frontotemporal dementia, vascular dementia, body Lewy dementias, as well as recommendations for the initial and general approach of patients. The diverse characteristics, etiologies, clinical and therapeutic presentations are reviewed. [ABSTRACT FROM AUTHOR]