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Background: Cow's milk protein allergy is the main allergic problem during the first year of life, possibly owing to immune and gastrointestinal systems poor maturation. To prevent allergic reactions, the content and type of proteins in infant formulas resemble those of breast milk. We believe that reactions are due rather to the amount than to the type of protein. Objective: To design a new formula with cow's milk that provides the infant with the main nutrients at an affordable cost and with lower risk for the development of allergies. Methods: Three-phase project: product design, industrial production and ex vivo assay to assess for anemia and type I allergic reaction by CD63 expression in basophils. Results: For every 100 calories, the content of protein was 2.0 g, carbohydrates 7.2 g and fat 0.5 g, which is higher than the indicated maximum value (4.5 g). Microbiologically, it was an innocuous food. CD63 expression was low in 57.1% of the babies and high in 42.9%. Conclusion: The new formula did not trigger any allergenic responses and can therefore be supplied to non-atopic infants. [ABSTRACT FROM AUTHOR]

Background: In Mexico City, where the Olive trees are scarce, the Oleaceae family has been recognized as one of the most important causes of pollen allergy, possibly related to cross-reactivity with other pollens of the Oleaceae family, as Fraxinus excelsior, Ligustrum vulgaris and Osmanthus americanus. Objective: To know the prevalence of sensitization to the Oleaceae family in Mexico City, cross-reactivity, as well as concurrent sensitizations, and vegetables and fruits associated to oral allergy syndrome (OAS). Patients and method: A prospective, longitudinal study was carried out during two months, among patients who attended the outpatient allergy clinic of the General Hospital of Mexico with symptoms suggestive of respiratory allergy. A questionnaire to search OAS was used, and skin Prick tests to pollens were performed. Results: Among 279 patients, 164 (58.8%) had respiratory allergy and positive skin prick test (SPT) to pollens. Olea europaea had the highest prevalence of SPT reactivity (52.4%), followed by Fraxinus excelsior (43.3%), Ligustrum vulgaris (36.6%) and Osmanthus americanus (15.9%). There were OAS in 53.5%, 50.7%, 50% and 53.8%, respectively, mainly related to peach, apple, kiwi, pear and banana. Olive monosensitization was found in 5.5%. Conclusion: In this study, Olea europaea had the highest prevalence of positive reactivity to pollens in Mexico City, then its sensitization must be determined routinely. [ABSTRACT FROM AUTHOR]