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With the widespread use of proton pump inhibitors (PPIs) have appeared unexpected effects adverse. Recently there have been case reports of severe hypomagnesaemia associated with PPIs with producing of hypokalemia, hypocalcaemia and hypoparathyroidism leading to clinical manifestations endanger life of the patients. The cause of hypomagnesaemia seems to be an alteration in the intestinal absorption induced by prolonged use of PPIs. This is an unknown adverse effect by clinicians and therefore goes unnoticed as the cause of hypomagnesaemia. The diagnosis requires a high degree of clinical suspicion. It should monitor serum magnesium levels in patients treated which PPIs. [ABSTRACT FROM AUTHOR]

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