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Baclofen is a GABA-B agonist drug used to treat mainly spasticity but it has shown some possible analgesic properties. The baclofen induced antinociception by GABA agonists depressing the central nervous system by decreasing the release of glutamate and aspartate. Objectives: Determine the antinociception effect of Baclofen after it administration in a model of neuropathic pain in rats. Material and methods: Thirty male albino rats of Wistar strain, weighing between 150 and 250 grams were used. Rats were prepared for surgery and anesthetized with intraperitoneal chloral hydrate. Right sciatic nerve was isolated and injured by constriction. Baclofen was applied in different doses (1, 4, 6 mg/kg) intra-peritoneal according to the experimental groups. The rats were subjected to a battery of various pain tests. Each test was performed on both hind legs. Repetitive ANOVA test was used and the p < 0.05 was significant. Results: Pain measurement with Von Frey filaments of the left leg was 1.13 (± 0.32) mm as a base line in all groups, compared with the right leg that was1.04 (± 0.36) mm as the same condition. Significant differences were obtained after baclofen application in all the groups. Altered gait percentages in each group was remarkable in group A, and was ameliorate in group B, C, and D (p < 0.001) and normal in group E. Autotomy, edema and leg retraction was observed like complications main in group C (20%) and D (40%). Conclusions: Baclofen demonstrated as an excellent antinociception drug to treat neuropathic pain in rats, and was dose-dependent. [ABSTRACT FROM AUTHOR]