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Diabetes Mellitus Type 2 presents with major serious complications such as chronic kidney failure, liver disease, diabetic neuropathy, cerebrovascular disease created by metabolic dysfunction that leads to a state of chronic inflammation in these patients. With the objective of evaluating the influence of rectal ozone therapy as complementary therapy in patients with Type 2 diabetes Mellitus. 38 patients suffering Diabetes Mellitus Type 2 were selected and randomly divided into two groups. The first group (Ozone) received conventional treatment plus rectal ozone therapy and the second (Conventional) only received conventional treatment. Blood glucose, glycosylated hemoglobin, LDL-cholesterol, VLDL-cholesterol and triglycerides were measured in blood, markers of liver and kidney damage and the DNA-4 scale of neuropathic pain were measured at the beginning and at end of treatments with rectal ozone therapy. The group of patients who received rectal ozone therapy plus conventional treatment showed a significant decrease in glycemic, glycated hemoglobin, VLDL-cholesterol, triglyceride, LDL-cholesterol values compared to the group with conventional treatment. It reflected significant improvement in the liver and kidney damage markers as well as the levels of the DNA.-4 pain scale, compared to the group that only received conventional treatment. The complementary application of rectal ozone therapy showed a protective effect on metabolic, liver and kidney function in patients with Type 2 Diabetes Mellitus, and also showed a certain analgesic character by reducing pain in said disease. [ABSTRACT FROM AUTHOR]

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