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The development of the Artificial Pancreas, which consists of the implementation of a continuous insulin infusion pump and sensors for blood glucose monitoring, is a priority for the treatment of subjects with type 1 diabetes. To achieve a complete automation of this process several control strategies have been proposed with the aim of maintaining blood glucose levels in the normoglycemic range. Among the developed strategies, those based on adaptive control stand out, to counteract the effect of physiological variations that are inherent to the patient. However, these strategies require full state measurement, which is not an easy task because of sensors cost and the inherent difficulty in direct measurement of physiological variables. Therefore, in this work, an adaptive control strategy with guaranteed stability is used for an insulin control model, and a nonlinear sliding mode observer is designed to estimate the state variables that the controller requires. With the complete control-observer system, satisfactory results are obtained by compensating for meal intake and errors between the model and subject parameters. [ABSTRACT FROM AUTHOR]