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Purpose: The goal in this study was to measure the renal function after the kidney donation for transplantation in our Center. Method: We conducted a retrospective, observational, longitudinal, and comparative analysis in 71 donors attended during period 2002-2004. Gender, age, relationship with the donor, weight, height, surgical complications, body mass index (BMI), arterial tension, plasmatic creatinine, nitrogen binding to protein, albumin, creatinine clearance in 24 hour urine collection, estimated glomerular filtration rate (GFR) and proteinmicroalbumin in 24 hour urine collection were determined; these data was measured before and after the donation. Wilcoxon test was used to determine the statistical significance at level p < 0.05. Results: Thirty-four were males and 37 were females; the mean age was 35.9 years old; 79% were related with the donor. Only 19% had body mass index > 30 and this no changed after donation and no afected the kidney function. The complications not requiring operation were observed in 2.8% and the complications requiring operation were observed in 1.4%; none of these influenced in the kidney function and donor's life. The mean follow-up was 12.42 months. The plasmatic creatinine increased from 0.83 to 1.13 mg/dL after and before donation, respectively (Wilcoxon, p < 0.001). The GFR calculated by creatinine clearance decreased significantly from 113.14 mL/min to 83.73 mL/min (Wilcoxon, p < 0.001). The GFR declined by 26%. The estimated GFR by Levey equation showed a decrease from 101.09 to 74.09 mL/min too. There were no proteinuria neither micro-albuminuria. Conclusion: The plasmatic creatinine increase after donation, but this rate is within the expected values for individuals that have two kidneys. The GFR calculated by creatinine clearance decline by 26%; however, this value is expected because the donors have only one kidney. The Levey equation was made for patients with two kidneys, so it needs a new or modified equation that determine the GFR in individuals with one kidney secondary to unilateral nephrectomy, but these individuals will considered with some degree of renal failure. [ABSTRACT FROM AUTHOR]