Search

This study was conducted to investigate the protective effects of Betanin active ingredient in red beetroot plant (Beta vulgaris) in elderly rats exposed to chronic toxicity of monosodium glutamate (MSG). A total of 48 elderly rats were randomly divided into 4 different groups. At the end of the 28–day study, the rats were sacrificed under deep anesthesia. Total antioxidant capacity (TAC), total oxidant capacity (TOC), paraoxonase (PON), thiol, malondialdehyde (MDA), and nitric oxide (NO) levels were investigated in rat blood serum using the spectrophotometric method. Oxidative Stress Index (OSI) was calculated by dividing TOC by TAC. Total bilirubin was measured with the colorimetric method using an ELISA kit. Liver tissues were stained with hematoxylin–eosin (HE) for histopathological examination. The difference in serum levels of TAC, TOC, OSI, PON, MDA, and thiol was statistically significant between the groups (P0.05). The analysis of histopathological findings revealed uncommon mild hydropic degeneration in the MSG group and almost normal histological appearance in the MSG+Betanin group. This study demonstrated that betanin could increase the antioxidant effect and reduce the histopathological damage caused by MSG.

Context: The possible toxic effects of monosodium glutamate (MSG) on ovarian functions have not been thoroughly evaluated in contrast to testicular functions. Few studies documented that MSG showed histological alterations. Aims: To investigate the subacute effects of oral MSG (2 g/kg) on estrogen level and numbers of ovulated oocytes and histological changes in ovary of Sprague-Dawley (SD) rats. Methods: Virgin young adult SD female rats with a regular estrous cycle were randomly assigned to either MSG-treated group or control group, and the duration of treatment was 14-16 days for oral administration MSG or vehicle (distilled water), respectively. Results: Oral MSG treatment with doses of 2 g/kg/day showed significantly (p

Introduction: Monosodium Glutamate (MSG) is used as a flavor enhancer, but its actions in health are a debated issue. Its effects on the Psychoneuroendocrine-immune system are not known. Objective: To determine the effect of monosodium glutamate on body mass, reproduction and lactation in Balb / c mice and their offspring. Materials and methods: 20 mice in the neonatal period are administered subcutaneous GMS 4mg / kg diluted in 10 microliters of distilled water and others with 0.9% NaCl. At 90 days the Lee Index is calculated to determine the body weight, then they are paired in 4 groups of 5 mice where males and females are interbreed with GMS and 0.9% NaCl. The weight of the offspring in these crosses is compared to indirectly assess lactation. Results: 100% of mice treated with MSG are obese because they have a Lee Index higher than 0.300. The females with GMS give birth to less than 4 offspring while the females (NaCl) mate with males (GMS) have an average offspring of 4-5 offspring. The weight of the offspring born of parents treated with MSG is lower than those not treated. Conclusions: MSG administered subcutaneously in murine neonates induces obesity. Reproduction and lactation are affected in those treated with MSG since the number of offspring and the body weight of their offspring is lower than that of the untreated.

Introduction: Monosodium Glutamate (MSG) is used as a flavor enhancer, but its actions in health are a debated issue. Its effects on the Psychoneuroendocrine-immune system are not known. Objectives: To determine the effect of monosodium glutamate on body mass, reproduction and lactation in Balb / c mice and their offspring. Methods: 20 mice in the neonatal period are administered subcutaneous GMS 4mg / kg diluted in 10 microliters of distilled water and others with 0.9% NaCl. At 90 days the Lee Index is calculated to determine the body weight, then they are paired in 4 groups of 5 mice where males and females are interbreed with GMS and 0.9% NaCl. The weight of the offspring in these crosses is compared to indirectly assess lactation. Results: 100% of mice treated with MSG are obese because they have a Lee Index higher than 0.300. The females with GMS give birth to less than 4 offspring while the females (NaCl) mate with males (GMS) have an average offspring of 4-5 offspring. The weight of the offspring born of parents treated with MSG is lower than those not treated. Conclusions: MSG administered subcutaneously in murine neonates induces obesity. Reproduction and lactation are affected in those treated with MSG since the number of offspring and the body weight of their offspring is lower than that of the untreated.

La normativa nacional e internacional permite adicionar a las mezclas deshidratadas para caldos y sopas resaltadores del sabor tales como glutamato monosódico (GMS) y los ácidos inosínico y guanílico o sus sales fosfatadas (IMF y GMF, respectivamente), solos o combinados para lograr un efecto sinergístico. Los objetivos de este estudio fueron: 1) determinar mediante un panel sensorial, el efecto sinergístico en el sabor de una sopa de pollo deshidratada cuando se usa mezcla de resaltadores y 2) cuantificar los 5´-ribonucleótidos en dicha matriz. La intensidad del sabor a pollo se determinó empleando un panel de 6 personas previamente entrenadas. Los 5´-ribonucleótidos se cuantificaron empleando HPLC. Los resultados con el panel entrenado comprobaron que la combinación utilizada de GMS, IMF y GMF potencia significativamente (pThe international and national regulation permits the addition of flavour enhancers such as monosodium glutamate (MSG) and inosinic and guanilic acids and their fosfated salts (IMP or GMP, respectively) alone or combined to dehydrated mixtures of broths and soups in order to obtain a synergistic. The objectives of this study were: 1) to determine, through a sensorial panel, the synergistic effect on the flavour of a dehydrated chicken soup to which flavour enhancers were added and 2) quantify the 5´-ribonucleotides in such matrix. The intensity of the chicken flavour was determined using a previously trained 6-member panel. The 5´-ribonucleótidos were determined using the HPLC technique. The results using the panel demonstrated that the combination of GMS, IMF and GMF used potentiates significantly (p

El ácido glutámico como tal o en su forma ionizada L-glutamato (GLU) es uno de los aminoácidos más abundantes en la naturaleza debido a que cumple funciones importantes a nivel celular y sistémico. En el intestino y el hígado, por ejemplo, el GLU constituye fuente de energía y es precursor de moléculas de relevancia biológica. Mientras que en el sistema nervioso central de los mamíferos actúa como neurotransmisor excitatorio, debido a la interacción con receptores específicos distribuidos en el cerebro. Además al GLU se le ha relacionado con la potenciación a corto y largo plazo de la memoria y el aprendizaje. Por otro lado, el consumo de GLU o de su sal monosódica (GMS) como aditivo alimentario genera el gusto umami, palabra japonesa que significa sabroso. El consumo de GMS ha sido considerado seguro por diferentes organizaciones que evalúan la inocuidad de uso de los aditivos alimentarios, razón por la cual han establecido una ingesta diaria admisible (IDA) "no especificada" y lo clasifican como un ingrediente reconocido como seguro o sustancia GRAS (por sus siglas en inglés, Generally Recognized Safe Substance). En esta revisión se presentan los aspectos del metabolismo del GLU, su papel en la degustación de los alimentos y la inocuidad del uso del GMS.