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2 results on '"high‐dose rate brachytherapy"'

1. ANÁLISIS DOSIMÉTRICO EN BRAQUITERAPIA GINECOLÓGICA DE ALTA TASA DE DOSIS

Author

Cristián Valdés P, Apolo Salgado F, Claudio Missarelli P, and Cristián Parra P

Subjects
dosimetry, business.industry, Brachytherapy, dosimetría, Obstetrics and Gynecology, High-Dose Rate Brachytherapy, cáncer cervicouterino, alta tasa de dosis, high dose rate, Dosimetry, Medicine, Tomography, cervix carcinoma, business, Nuclear medicine, Braquiterapia
Abstract

Objetivo: Analizar la dosimetría en braquiterapia ginecólogica para el dispositivo Fletcher-Suit-Delclos con alta tasa de dosis, mediante placas radiográficas ortogonales (anteroposterior y lateral) versus tomografía axial computada (TAC). Material y Métodos: Se compararon dosimetrías de 4 implantes, realizadas con placas ortogonales y TAC pélvico en la Unidad de Braquiterapia del Instituto Nacional del Cáncer durante el mes de febrero del año 2006. Se prescribieron dosis de 8 Gy/fracción a punto H y se evaluó dosis a vejiga, recto y vagina según norma internacional. Resultados: Las dosimetrías por TAC mostraron puntos calientes superiores a las placas ortogonales, para recto un 133% y para vejiga un 260% más aproximadamente. El porcentaje de volumen blanco incluido es subestimado con la dosimetría efectuada por placas ortogonales. Conclusiones: La dosimetría por placas ortogonales muestra menor exactitud que el TAC. Los volúmenes blanco no son satisfactoriamente cubiertos por la curva de isodosis prescrita. La dosis acumulada, probablemente, sea más relevante que la dosis fracción Objective: We analyze the gynecologycal high dose rate brachytherapy dosimetry using the Fletcher-Suit-Delclos device, comparing orthogonal films (anteroposterior and lateral) versus axial computarized tomography. Methods: 4 implants were analized with orthogonal films and axial computarized tomography in the Brachyhterapy Unit of the National Cancer Institute on February 2006. The dose/fraction was 8 Gy to the H point. The bladder, rectal and vaginal dose point were evaluated according to international specifications. Results: Axial computarized tomography reveals hot points higher than orthogonal films dosimetries (133% and 260% for bladder and rectum respectively). The target volumen included was underestimated with the classical orthogonal film dosimetry. Conclusions: The orthogonal film dosimetry shows smaller accuracy than axial computarized tomography. The target volumens were not satisfactorily covered by the prescribed isodosis curve. The dose accumulated could, probably, be more prominent than the dose/fraction

Published
2007

2. High-dose rate brachytherapy as monotherapy in prostate cancer: A systematic review of its safety and efficacy.

Author

Sánchez-Gómez LM, Polo-deSantos M, Rodríguez-Melcón JI, Angulo JC, and Luengo-Matos S

Subjects
Humans, Male, Radiotherapy Dosage, Treatment Outcome, Brachytherapy adverse effects, Brachytherapy methods, Prostatic Neoplasms radiotherapy
Abstract

Context: High-dose rate brachytherapy (HDR-BT) is an increasingly popular treatment for patients with localised prostate cancer (PC)., Objective: To assess the safety and efficacy of HDR-BT as monotherapy in PC., Acquisition of Evidence: A systematic literature review was conducted through searches on MEDLINE (PubMed), Cochrane Library, CDR, ClinicalTrials and EuroScan. We assessed safety and efficacy indicators., Summary of the Evidence: We selected 2 reviews and 12 uncontrolled studies, included in these 2 reviews. In terms of efficacy, local control in 6 studies was 97-100%. The biochemical progression-free survival varied as follows: 85-100% for low risk and 79-92% for high risk. Survival free of metastases was >95% at 8 years, except in one study where the survival rate was 87% at 5 years. The overall survival was ≥95% in 8 studies. In terms of safety, most of the studies recorded acute and long-term genitourinary and gastrointestinal complications, especially grade ≥2. Only 3 studies found grade 4 complications. All studies, except for one without complications, observed genitourinary complications that were more frequent and severe than the gastrointestinal complications. Two studies assessed the quality of life and showed an initial reduction in various domains and subsequent partial or total recovery, except in the sexual domain., Conclusions: HDR-BT is effective as monotherapy, especially in cases of low to intermediate risk. There is insufficient information on high-risk patients. The short to medium-term toxicity was acceptable. Further research needs to be funded to provide more information on the long-term safety and efficacy of this treatment., (Copyright © 2016 AEU. Publicado por Elsevier España, S.L.U. All rights reserved.)

Published
2017
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