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The seismic moment cycle at plate boundaries may be imaged by the Moment-Ratio Method (MRM). In this exploratory technique the fluctuation of cumulative moment deficiency is used as an indicator of the cycle of degradation and recovery of free energy along an active tectonic region. A 20-year half-life is assumed for the healing process of earthquake ruptures along the Pacific plate boundary. Using the Pacheco-Sykes Catalog of large shallow earthquakes (M>7), we estimate the moment ratio for Japan and Mexico at 20-year intervals during the 20th century. Moment-ratio peaks for 1980 correlate with subsequent earthquakes of magnitude M>7 during the following 20-year period in Mexico and Japan.

We reported a perineal lipoblastoma in a 5-year-old girl located in the right labia mayor. The lesion gradually increased within 6 months. Ultrasound and magnetic resonance imaging (MRI) showed a limited solid heterogenous tumor with fatty component. After it had been surgically removed, the anatomopathological examination confirmed that it was a lipoblastoma. Lipoblastoma is a rare benign mesenchymal tumor of infancy and early childhood. Symptoms vary depending on localization; signs of compression of adjacent organs may be seen. This type of unusual soft tissue tumors occurred most often in under 3 years old. The localization of lipoblastomas is predominantly in the extremities but may be also found in other sites including the head and neck, trunk, mediastinum, kidney, mesentery, retropritoneum and perineum. The suspicion should be considered according to ultrasound and MRI findings., (Sociedad Argentina de Pediatría.)

Background: The "secondary injury" theory of liver failure indicated that hyperammonaemia due to liver failure causes further deterioration of hepatocytes. Our previous studies have demonstrated that high blood ammonia levels may lead to hepatocyte apoptosis, as NH 4 Cl loading caused metabolic acidosis and an increase in sodium-hydrogen exchanger isoform 1 (NHE1). In this study, we established a hyperammonia hepatocyte model to determine the role of NHE1 in the regulation of hepatocyte apoptosis induced by NH 4 Cl., Materials and Methods: In current studies, intracellular pH (pHi) and NHE1 activity were analyzed using the pHi-sensitive dye BCECF-AM. The results showed that intracellular pH dropped and NHE1 activity increased in hepatocytes under NH 4 Cl treatment. As expected, decreased pHi induced by NH 4 Cl was associated with increased apoptosis, low cell proliferation and ATP depletion, which was exacerbated by exposure to the NHE1 inhibitor cariporide. We also found that NH 4 Cl treatment stimulated PI3K and Akt phosphorylation and this effect was considerably reduced by NHE1 inhibition., Conclusion: This study highlighted the significant role of NHE1 in the regulation of cell apoptosis induced by hyperammonaemia., (Copyright © 2018 Elsevier España, S.L.U. All rights reserved.)