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The purpose of the work is to highlight experimental methodical approaches to the representation of certain aspects of modern Ukrainian vocal art on the example of the organization of research, educational and performing activities of master's students of the Faculty of Arts of V. Hnatyuk TNPU. The research methodology consists in the use of methods of historical and cultural discourse, historical and musicological positions on the problems of vocal art, in the implementation of activity and integrative approaches based on the example of art pedagogy. Attention is focused on the problem of representation of the main problems of the development of modern Ukrainian vocal art on the example of the organization of research, educational and performing activities of future music teachers. Taking into account the tasks of their professional training, the specifics and prospects of their future pedagogical and performing activities, we have already made attempts to extrapolate the history of performing schools to the content of the "Methodology of Music Education" course and the subjects of the school cycle, in particular, the reading of the "Artistic Culture of Ukraine" course during 2019–2020. The scientific novelty consists in the presentation of an integrative approach to the organization of the research, educational and performance activities of master's students on the example of the interaction of teachers of specialized lecture-theoretical ("History of Ukrainian Music", "Contemporary Music"), research courses ("Fundamentals of Music and Pedagogical Research", "Methodology of Scientific research", "Fundamentals of musical interpretation") and practical disciplines ("Vocal") during 2020–2021. A number of examples of research work of master's students are presented (essays, "musical quizzes", questionnaires, etc., related to the problems of modern musical art). A block of master's research materials related to musical Ternopil, with the organization of the competition and festival movement, is separately allocated. Excerpts from essays of master's students on the topic "Show business: pros and cons" are given. As examples of the cooperation of academic supervisors with vocal teachers, the content of master's studies was clarified, respectively - programs of master's students' concerts. For example, creative projects "Song about a song", "Moment". Conclusions. We believe that the best examples of modern pop songs are an important contribution to the vocal art of Ukraine. Their role especially increases in periods of social challenges, war tragedies as a reaction-protest of artists and society in general. At the same time, it is an interesting research material, a high-value performing and educational repertoire, which should be qualitatively presented in performance classes of art institutions. So, the layer of popular musical culture and performance, represented by the activities of famous soloists and bands from different regions of Ukraine, participants of the competition-festival movement in Ukraine and abroad, was and remains the subject of thorough comparative research.

Background: The impact of enteral nutrition (EN) on surgical risk in Crohn's disease (CD) patients suffering from spontaneous intra-abdominal abscess (IAA) was evaluated. Methods: CD patients diagnosed with spontaneous IAA from 2008 to 2015 were included in the study. The impact of EN on surgical risk was evaluated using both univariate and multivariate analyses. Results: A total of 87 patients were enrolled, 66 (75.9%) were male. The mean age at the development of an abscess was 30.2 ± 10.1 years and the median duration of illness from CD diagnosis until the development of an abscess was three (2-6) years. After a median follow-up of 1.9 (1.1-2.9) years, surgical intervention was performed in 42 patients (48.3%). Patients treated with EN were less likely to require surgical intervention (26.1% vs 56.3%, p = 0.01). Multivariate analysis showed that EN was an independent protective factor for the risk of surgery with a hazard ratio of 0.27 (95% confidence interval: 0.11-0.65, p = 0.004) after adjusting for abdominal pain, history of abdominal surgery, concomitant intestinal stenosis and prior use of antibiotics within three months. Conclusions: Surgical intervention is common for CD patients with IAA. Appropriate application of EN may help obviate the need for surgical treatment.

Nonketotic hyperglycinemia is an extremely rare autosomal recessively inherited glycine encephalopathy caused by a deficiency in the mitochondrial glycine cleavage system, which leads to severe clinical symptoms. Nonketotic hyperglycinemia is characterized by complex and diverse phenotypes, such as hypotonia, seizures, cognitive impairment, developmental delays and myoclonic jerks that may lead to apnea and even death. Here we report a 1-year-old boy with myoclonic seizures, hypotonia and coma; he had elevated plasma and cerebrospinal fluid glycine levels, and cerebrospinal fluid/plasma glycine ratio was 0.24. Two novel heterozygous mutations confirm the diagnosis of nonketotic hyperglycinemia. One is a missense mutation c.2516A>G (p.Y839C) and the other one is a splicing mutation c.2457+2T>A in the GLDC gene., (Sociedad Argentina de Pediatría.)