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ABSTRACTThis research studies the impacts of microcrystalline cellulose (MCC) concentrations on the physicochemical properties of spray-dried water-in-oil-in-water (W/O/W) vitamin C double emulsion powder Four MCC concentration (1%, 1.5%, 2%, and 2.5%) were used to produce the vitamin C double emulsion powder. The results of the emulsion’s creaming index, flow behaviour index, zeta value, and particle size indicated that these parameters decreased when the MCC concentration increased. Scanning electronic microscopy (SEM) analysis showed that the higher MCC concentration resulted in a smoother surface In general, the MCC concentration increased, the particle size, hygroscopicity, solubility, water content, and water activity of the double emulsion powder decreased. Double emulsion powder containing 2% MCC presented the highest level of antioxidant activity and was mostly stable after storage for 56 days. Before and after drying, transmission electron microscope (TEM) analysis of the morphological characteristics of the liquid emulsion showed that the concentration of 2% MCC in the emulsion could form a W/O/W double emulsion structure. In conclusion, the addition of MCC significantly affect the properties of vitamin C double emulsion.

The antioxidant power of eugenol and vitamin C was examined by analyzing the ability of these ligands to bind to the NADPH oxidase protein target and evaluating their bond interactions with critical residues. The results confirm that docked ligands are more stable in the specified active region of 2CDU during a MD simulation of 100 ns and 2CDU protein-ligand interactions with docked ligands showed significant hydrogen bond, hydrophobic, and water bridge formation. Eugenol exhibits hydrogen bond interactions with critical residues in the selective pocket in comparison to vitamin C. Also, eugenol had a similar binding orientation and very considerable stability in the selective pocket of 2CDU with a high binding energy with lipophilic energy. The electrostatic potential maps indicate that for eugenol, the –OH and –OCH3 sites, while that the –OH and –CO functional groups in vitamin C are responsible of the antioxidant activities of these compounds. HAT and SET mechanisms suggest that eugenol may become a better antioxidant than vitamin C.

Objetive. An experiment was conducted to evaluate the feed intake, digestibility and growth of pigs fed with two feeds (A and K) specially formulated for this species and a commercial feed for growing rabbits with supplementation of vitamin C (RF+VC). Materials and methods. Eighteen Guinea pigs of 248±38 g initial body weight were distributed in a completely randomized design with factorial arrangement 3×2 (dietary treatments and sex). Feed and neutral detergent fiber intake, weight gain, feed/gain, and morphometric variables were measured individually for 30 days. Dry matter and neutral detergent fiber digestibility were measured during the last seven days of the experiment. Results. There were no differences on feed intake (p=0.88); however, the dry matter digestibility was higher (p0.05). There were no differences (p>0.01) in the morphometric variables among dietary treatments, but there were sex differences as the males were bigger than the females (p

Introduction: Vitamin C (Vit C) is an organic chemical compound from the group of unsaturated polyhydroxy alcohols. It influences physiological processes such as the facilitation of iron absorption, hormone and carnitine synthesis, and is also involved in epigenetic processes. It is a vitamin, which means that it must be provided in food. It is also an antioxidant used as a food additive. In recent times, its pleiotropic use has been proven in the treatment of immune deficiencies, the treatment of skin diseases, bone diseases and may also be used in new cancer treatment regimens. Aim of the study: To review the current literature on the use of vitamin C in various fields of health and science. Materials and Methods: We reviewed the literature available in PubMed, using the key words: "vitamin C"; "ascorbid acid"; "cancer treatment"; "vitamin C immune function". Results: Vitamin C has pleiotropic effects on the human body, both through its effects on cells and tissues and through its antioxidant mechanisms and regulation of gene expression. It has been shown to be a key antioxidant with anti-inflammatory and immune system supportive effects. Its effect of slowing down skin photo-ageing by reducing the amount of metalloproteinases induced by reactive oxygen species has been noted in the literature. Vitamin C has been shown in studies to reduce the risk of osteoporosis due to its osteoclast inhibitory properties. Beneficial effects of high-dose intravenous infusions have also been demonstrated in the treatment of cancer, as well as about reducing organ failure and vascular damage in patients with ARDS and sepsis. Summary: The versatile action of vitamin C has made it the subject of intense research. However, the reports in the literature to date on its use require further studies on larger groups of people to confirm its effects.

Abstract “mora de Castilla” is a native shrub of the Andean tropics and can be found in Colombia, Ecuador, Mexico, and other countries of this region. In Colombia, this fruit is cultivated by small producers and is an important source of income and rural employment. “mora de Castilla” is in great demand for domestic consumption as well as for export because it can be consumed fresh or processed and because of its extraordinary organoleptic and nutritional attributes. Risaralda is one of the departments in which Rubus glaucus Benth. is cultivated; there, plants with and without prickles are widely distributed. Although some studies have been carried out on these cultivars, it is necessary to evaluate and compare some of their attributes as an approach to recognize potential uses in agribusiness. Therefore, a physicochemical characterization was performed, the vitamin C content was evaluated, the amount and profile of anthocyanins were determined, and the antioxidant capacity of fruits of “mora de Castilla” with and without prickles was analyzed. The physicochemical parameters evaluated were weight, pH, soluble solids and titratable acidity. The content of vitamin C was evaluated using the 2-nitroaniline spectrophotometric method, and anthocyanins were evaluated using 2 methods: spectrophotometry (pH differential) and chromatography (HPLC). Finally, the antioxidant capacity was determined using the FRAP and DPPH methods. Significant differences were found between the municipalities as well as between the materials with and without prickles with regard to antioxidant capacity and vitamin C and anthocyanin content, with the highest values for fruits grown in the municipality of Pereira, Risaralda. The results obtained indicate that “mora de Castilla” with and without prickles is a fruit of high quality and promise because of its high content of bioactive compounds (vitamin C and anthocyanins), its relevant function as an antioxidant and its valuable organoleptic attributes.

Introduction:There is a wide range of seawater products for nasal lavages. Their efficacy and superiority over conventional saline solutions are not well established. Objectives: The aim of this study was to analyse the best-selling seawater products, as well as reviewing the most recent literature regarding nasal lavages. Methods:A comparative study of composition, administration mode, age indicated for its use, price and bibliography provided on the web of the seawater products usually available in pharmacies was performed. Analysis of the bibliography provided and review of the scientic evidence regarding nasal lavages with saline solutions or seawater. Results: 44 products from 11 manufacturers were analysed. The concentration of sodium chloride varies from 0.9% to 2.5%. The most frequent mode of application is spray. The addition of plants, salts and other components is common. Only two brands provide bibliographic references on their website. According to the literature reviewed, both saline solutions and seawater seem especially useful in the treatment of upper respiratory tract infections and allergic rhinitis.Conclusions:There is no solid scientic evidence regarding the benets of nasal lavages. With the current evidence it is not possible to recommend seawater over conventional saline or to establish the optimal concentration of the solution or the most convenient mode of administration. The addition of elements to seawater solutions is not justied enough.