1. [Human reservoirs of Pneumocystis].
- Author
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Wissmann G, Morilla R, Friaza V, Calderón E, and Varela JM
- Subjects
- AIDS-Related Opportunistic Infections epidemiology, AIDS-Related Opportunistic Infections microbiology, Animals, Antifungal Agents, Carrier State microbiology, Drug Resistance, Multiple, Fungal genetics, Forecasting, Genotype, Humans, Mammals microbiology, Mutation, Missense, Pneumonia, Pneumocystis transmission, Species Specificity, Carrier State epidemiology, Disease Reservoirs microbiology, Pneumocystis carinii drug effects, Pneumocystis carinii genetics, Pneumocystis carinii isolation & purification, Pneumocystis carinii pathogenicity, Pneumonia, Pneumocystis epidemiology
- Abstract
Pneumocystis jirovecii, the fungal agent that causes Pneumocystis pneumonia (PCP), is known to exclusively infect humans. Molecular studies have enabled detection of this fungus in individuals who have been colonized by P. jirovecii. Such colonization, found in several populations, seems to act as a human reservoir for the fungus. Various studies have reported mutations associated with sulfa resistance in P. jirovecii strains isolated from colonized patients, who can transmit the mutant genotype to PCP-susceptible individuals. The growing interest in P. jirovecii colonization may prompt the design of new prevention and management strategies for PCP., (Copyright 2008 Elsevier España, S.L. All rights reserved.)
- Published
- 2010
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