1. [Causes and management of severe acute liver damage during pregnancy].
- Author
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Sepulveda-Martinez A, Romero C, Juarez G, Hasbun J, and Parra-Cordero M
- Subjects
- Female, Gestational Age, Humans, Pregnancy, Pregnancy Trimester, Third, Fatty Liver etiology, Fatty Liver therapy, HELLP Syndrome etiology, HELLP Syndrome therapy, Liver Failure, Acute etiology, Liver Failure, Acute therapy, Pregnancy Complications etiology
- Abstract
Abnormalities in liver function tests appear in 3% of pregnancies. Severe acute liver damage can be an exclusive condition of pregnancy (dependent or independent of pre-eclampsia) or a concomitant disease. HELLP syndrome and acute fatty liver of pregnancy are the most severe liver diseases associated with pregnancy. Both appear during the third trimester and have a similar clinical presentation. Acute fatty liver may be associated with hypoglycemia and HELLP syndrome is closely linked with pre-eclampsia. Among concomitant conditions, fulminant acute hepatitis caused by medications or virus is the most severe disease. Its clinical presentation may be hyper-acute with neurological involvement and severe coagulation disorders. It has a high mortality and patients should be transplanted. Fulminant hepatic failure caused by acetaminophen overdose can be managed with n-acetyl cysteine. Because of the high fetal mortality rate, the gestational age at diagnosis is crucial.
- Published
- 2015
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