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9 results on '"Metanephrine urine"'

1. Performance of plasma free metanephrines in diagnosis of pheochromocytomas and paragangliomas in the population of Asturias.

Author

Martínez-Morillo E, Valdés Gallego N, Eguia Ángeles E, Fernández Fernández JC, Prieto García B, and Álvarez FV

Subjects
Adolescent, Adrenal Gland Neoplasms blood, Adrenal Gland Neoplasms urine, Adult, Age Factors, Aged, Aged, 80 and over, Biomarkers, Tumor urine, Catecholamines blood, Catecholamines urine, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Metanephrine urine, Middle Aged, Paraganglioma blood, Paraganglioma urine, Pheochromocytoma blood, Pheochromocytoma urine, Reference Values, Sensitivity and Specificity, Vanilmandelic Acid urine, Young Adult, Adrenal Gland Neoplasms diagnosis, Biomarkers, Tumor blood, Metanephrine blood, Paraganglioma diagnosis, Pheochromocytoma diagnosis
Abstract

Introduction: Pheochromocytoma and paraganglioma are uncommon tumors whose best known symptoms include high blood pressure, palpitations, headache, and sweating. Clinical identification is not easy, however, and requires biochemical tests that allow for early diagnosis, including measurement of metanephrines levels. The aim of this study was to assess the diagnostic performance of plasma free metanephrines (PMETs) and to verify the transferability of the reference values used., Methods: PMETs levels were measured by liquid chromatography coupled to tandem mass spectrometry. Other biochemical tests evaluated (plasma catecholamine, urine metanephrine, catecholamine and vanilmandelic acid levels) were performed by liquid chromatography with electrochemical detection. Requests of these tests from 01/09/2015 to 31/10/2017 were reviewed, and both the reference values (document EP28-A3c) and the parameters of biological variation (Fraser method) for PMETs were estimated., Results: The study sample consisted of 1,279 patients (61.3% females) aged 0-90 years, including 19 with pheochromocytoma/paraganglioma. Tests requested included: PMETs (n=662), catecholamines (n=589), metanephrines (n=586), and vanilmandelic acid (n=513) in urine, and plasma catecholamines (n=228). Tests with higher sensitivity were urinary fractionated metanephrines (91.7%) and PMETs (82.4%). When performance was compared in patients with both tests (n=243), they detected the same number of tumors (90.9%), but PMETs showed greater specificity (93.5% vs 88.8%). Plasma normetanephrine levels showed a significant association with age (rho=0.19, P<.0001)., Conclusion: PMETs and urinary fractionated metanephrines are the biochemical tests with better performance in diagnosis of pheochromocytomas/paragangliomas., (Copyright © 2018 SEEN y SED. Publicado por Elsevier España, S.L.U. All rights reserved.)

Published
2019
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2. Abdominal pain and hipertensive crisis as initial manifestation of a malignant pheocromocytoma.

Author

Campos-Fernández J, Aguillo-Gutiérrez E, Agudo-Tabuenca A, Medrano-Navarro AL, and Borau-Maorad L

Subjects
Adrenal Gland Neoplasms complications, Adrenal Gland Neoplasms urine, Adrenalectomy, Adult, Bone Neoplasms secondary, Carcinoma diagnosis, Diagnosis, Differential, Emergencies, Fatal Outcome, Genes, Neoplasm, Headache etiology, Humans, Hyperglycemia etiology, Liver Neoplasms secondary, Liver Neoplasms surgery, Lung Neoplasms secondary, Lymphatic Metastasis, Male, Mediastinum, Metanephrine urine, Nephrectomy, Normetanephrine urine, Pheochromocytoma complications, Pheochromocytoma secondary, Pheochromocytoma urine, Abdominal Pain etiology, Adrenal Gland Neoplasms diagnosis, Hypertension etiology, Pheochromocytoma diagnosis
Published
2017
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3. [Hirschsprung's disease, RET proto-oncogene mutation and prophylactic thyroidectomy].

Author

Marcacuzco Quinto AA, Martínez Pueyo JI, Gómez Rodríguez P, and de la Cruz Vigo F

Subjects
Aged, Biomarkers, Tumor blood, Calcitonin blood, Carcinoembryonic Antigen analysis, Carcinoma, Medullary metabolism, Carcinoma, Medullary surgery, Colloid Cysts genetics, Colloid Cysts pathology, Exons genetics, Female, Humans, Metanephrine urine, Proto-Oncogene Mas, Thyroid Diseases genetics, Thyroid Diseases pathology, Thyroid Neoplasms metabolism, Thyroid Neoplasms surgery, Carcinoma, Medullary genetics, Hirschsprung Disease genetics, Multiple Endocrine Neoplasia Type 2a genetics, Mutation, Proto-Oncogene Proteins c-ret genetics, Thyroid Neoplasms genetics, Thyroidectomy
Published
2014
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4. [Adrenocorticotropic-secreting pheochromocytoma].

Author

Martín Jiménez ML, Palacios García N, Salas Antón C, Armengod Grao L, and Aller Pardo J

Subjects
Adrenal Gland Neoplasms diagnostic imaging, Adrenalectomy, Adult, Corticotropin-Releasing Hormone, Dexamethasone, Humans, Hydrocortisone blood, Hydrocortisone metabolism, Hydrocortisone urine, Hypertension etiology, Hypophysectomy, Hypothalamo-Hypophyseal System physiopathology, Male, Metanephrine urine, Neoplasms, Multiple Primary surgery, Osteoporosis etiology, Pheochromocytoma diagnostic imaging, Pituitary ACTH Hypersecretion diagnosis, Pituitary ACTH Hypersecretion surgery, Pituitary-Adrenal System physiopathology, Secretory Rate drug effects, Tomography, X-Ray Computed, ACTH Syndrome, Ectopic etiology, Adrenal Gland Neoplasms metabolism, Adrenocorticotropic Hormone metabolism, Neoplasms, Multiple Primary diagnosis, Pheochromocytoma metabolism
Published
2013
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5. [Catecholamine-induced cardiomyopathy triggered by pheochromocytoma].

Author

Navarro I, Molina M, Civera M, Ascaso JF, Real JT, and Carmena R

Subjects
3-Iodobenzylguanidine, Adrenal Gland Neoplasms diagnostic imaging, Adrenal Gland Neoplasms drug therapy, Adrenal Gland Neoplasms metabolism, Adrenal Gland Neoplasms surgery, Adrenal Gland Neoplasms urine, Adrenalectomy, Combined Modality Therapy, Diagnosis, Differential, Dyslipidemias complications, Female, Humans, Hypertension etiology, Metanephrine urine, Middle Aged, Myocardial Infarction diagnosis, Phenoxybenzamine therapeutic use, Pheochromocytoma diagnostic imaging, Pheochromocytoma drug therapy, Pheochromocytoma metabolism, Pheochromocytoma surgery, Pheochromocytoma urine, Radionuclide Imaging, Radiopharmaceuticals, Vanilmandelic Acid urine, Ventricular Dysfunction, Left diagnosis, Ventricular Dysfunction, Left physiopathology, Acute Coronary Syndrome etiology, Adrenal Gland Neoplasms complications, Catecholamines metabolism, Pheochromocytoma complications, Ventricular Dysfunction, Left etiology
Published
2011
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6. [Adrenal incidentaloma associated to elevated urinary normethanephrine in a patient with high blood pressure].

Author

Maciá Bobes C, Ronzón Fernández A, Alonso Troncoso I, Castaño Fernéndez G, Botas Cervero P, and García Delgado C

Subjects
Adenoma surgery, Adenoma urine, Adrenal Cortex Neoplasms surgery, Adrenal Cortex Neoplasms urine, Adult, Diagnosis, Differential, Humans, Hypertension therapy, Hypertension urine, Male, Pheochromocytoma urine, Predictive Value of Tests, Sensitivity and Specificity, Treatment Outcome, Adenoma diagnosis, Adrenal Cortex Neoplasms diagnosis, Hypertension etiology, Metanephrine urine, Pheochromocytoma diagnosis
Abstract

Objectives: To report one case of adrenal incidentaloma and to review the sensitivity and specificity of urine methanephrines in the diagnosis of pheochromocytoma., Methods: We report the case of a patient with high blood pressure and a left adrenal incidentaloma. Surgical excision of the mass was indicated after elevated urine methanephrine., Results: Pathologic study of the nodule established the diagnosis of cortical adenoma., Conclusions: The elevation of urine normethanephrine is a non-specific parameter for the diagnosis of pheochromocytoma.

Published
2004

7. [Congenital cyanotic heart disease and peripheral neurogenic tumor].

Author

Díez L, Rioja M, Cordero J, Caballero C, and Crespo A

Subjects
Abdominal Neoplasms diagnostic imaging, Abdominal Neoplasms urine, Adolescent, Chronic Disease, Epilepsy, Tonic-Clonic etiology, Fatal Outcome, Humans, Hypertension, Renovascular etiology, Hypoxia complications, Male, Metanephrine urine, Paraganglioma diagnostic imaging, Paraganglioma urine, Pulmonary Edema etiology, 3-Iodobenzylguanidine, Abdominal Neoplasms complications, Dextrocardia complications, Heart Defects, Congenital complications, Hypertension etiology, Paraganglioma complications, Pentetic Acid, Renal Artery abnormalities, Situs Inversus complications, Tomography, Emission-Computed, Single-Photon
Abstract

The association between neuroblastic tumours and congenital heart disease is widely confirmed in the literature references. The authors describe a case of a patient with congenital heart disease, high blood pressure, renal artery stenosis and high levels in 24 hours urine metanephrines. A MIBG-I-123 scintigraphy was essential for the diagnosis of neuroblastic tumour.

Published
1999

8. [Laboratory contribution to the diagnosis of pheochromocytoma].

Author

Rivero Marcotegui A, Grijalba Uche A, Palacios Sarrasqueta M, and Garcia Merlo S

Subjects
Adrenal Gland Neoplasms metabolism, Adrenal Gland Neoplasms urine, Biochemical Phenomena, Biochemistry, Biomarkers, Catecholamines blood, Catecholamines metabolism, Catecholamines urine, Chromatography, High Pressure Liquid, Clonidine, Colorimetry, Diagnosis, Differential, Fluorometry, Gastrointestinal Agents, Glucagon, Humans, Metanephrine urine, Pheochromocytoma metabolism, Pheochromocytoma urine, Sensitivity and Specificity, Sympatholytics, Vanilmandelic Acid urine, Adrenal Gland Neoplasms diagnosis, Pheochromocytoma diagnosis
Published
1996

9. [Sotalol interference in the determination of urinary metanephrine].

Author

Motjé Casas M, Fernández-Real JM, Bosch M, and Balanzá R

Subjects
Adrenal Gland Neoplasms diagnosis, Adult, Drug Interactions, False Positive Reactions, Female, Humans, Pheochromocytoma diagnosis, Anti-Arrhythmia Agents pharmacology, Metanephrine urine, Sotalol pharmacology
Published
1995

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