96 results on '"Mateos F"'
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2. Formulación magistral en patología de la mucosa oral
- Author
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Iglesias-Sancho, M., Llambí Mateos, F., and Salleras-Redonnet, M.
- Published
- 2020
- Full Text
- View/download PDF
3. La formulación magistral en la terapéutica dermatológica actual
- Author
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Sánchez-Regaña, M., Llambí-Mateos, F., Salleras-Redonnet, M., Iglesias Sancho, M., Collgros Totosaus, H., and Umbert-Millet, P.
- Published
- 2013
- Full Text
- View/download PDF
4. Cirrosis hepática
- Author
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García Buey, L., González Mateos, F., and Moreno-Otero, R.
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- 2012
- Full Text
- View/download PDF
5. Enfermedades pleurales: neumotórax
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Arenas Gordillo, M., Cabrera Galán, C., García Cuesta, A., Soto Campos, G., and Valenzuela Mateos, F.
- Published
- 2010
- Full Text
- View/download PDF
6. Caracterizacion de las vias de circulacion del agua, a la escala de la matriz rocosa, en rocas de baja permeabilidad. Revision metodologica
- Author
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Montoto, M. and Mateos, F.
- Published
- 2006
7. Función cognitiva y demencia en la hipertensión arterial
- Author
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Mora Maciá, J., Moreso Mateos, F., Viladoms Guerra, J., and Aguilera Jover, J.
- Published
- 2005
- Full Text
- View/download PDF
8. Fertiloscopia: una nueva técnica en el estudio de la esterilidad de origen desconocido
- Author
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Pérez-Medina, T., Folgueira Valle, G., Castellanos, P., Martínez Cortés, L., Mateos, F., and Bajo Arenas, J.
- Published
- 2001
- Full Text
- View/download PDF
9. Valoración de beta-HCG, estradiol y progesterona en mujeres portadoras de DIU
- Author
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Mateos, F., Bugella, I., Moreno, J., Seco, C., Garrido, A., Medina, T.P., and Bajo, J.M.
- Published
- 2001
- Full Text
- View/download PDF
10. Estudio de las lumbalgias en una empresa de construccion naval
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Delgado Ortega, M., García García, J.A., Rivas Mateos, F., Almorza Daza, J.Mª, and Astillero Puerto Real, Iziar
- Subjects
Dolor Lumbar ,Lista de chequeo ,Enfermedad lumbar ,Índices accidentalidad ,Profesograma ,Cuestionario nórdico ,Vigilancia de la salud ,Accidente lumbar ,acidente lumbar - Abstract
Originales La Empresa de Construcción Naval (IZAR Astillero Puerto Real) enmarcado dentro de un proyecto I + D inicia un análisis estricto del Estado de la Espalda de sus trabajadores. Constatamos los Indices de Accidentabilidad Lumbar1 en dos años en función de los índices recomendados por la organización Internacional del Trabajo, por otro lado, observamos el estado musculoesquelético2 de nuestros operarios en función del Cuestionario Nórdico Standarizado3. Procediendo posteriormente al Estudio de dichos datos:En la fase de Investigación planteamos una hipótesis que establece una relación directa entre accidente lumbar y molestias a nivel de la columna lumbar2. Una vez demostrada estadisticamente para un determinado número de profesiones, buscamos diferencias con la normalidad. No
- Published
- 2004
11. Indicaciones de la biopsia pleural
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Arenas Gordillo, M., Valenzuela Mateos, F., Pérez Grimaldi, F., and del Castillo Otero, D.
- Published
- 2010
- Full Text
- View/download PDF
12. Comportamiento hidráulico de la roca matriz en el acuífero costero del área calcárea de Campos (Mallorca)
- Author
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Mateos, F. J. and Montoto, M.
- Subjects
Petrophysical characterization ,Hydraulic properties ,Physical properties ,Rock forming components ,Anisotropy ,Rock matrix ,Heterogeneity ,Limestone ,Porosity - Abstract
In the framework of a wider European study of saline intrusions in coastal environments, the hydraulic behaviour of the rock matrix at the calcareous Campos site coastal aquifer (Majorca) has been characterized. This characterization is performed on rock cores in laboratory; its main objective is the relation between the hydraulic properties of the rock matrix and the rock forming components of petrophysical significance, specially the pore space structure. The anisotropy and heterogeneity is previously analyzed. The real and apparent density, effective and non-effective porosity, range of pore throat size, free and forced water absorption, water desorption, coefficient of capillarity and water vapour permeability have been evaluated. Seven different types of porosity according textural considerations have been established
- Published
- 2004
13. Hydraulic behaviour of the rock matrix at the calcareous Campos site coastal aquifer (Majorca, Spain)
- Author
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Mateos, F. J. and Montoto, M.
- Subjects
Petrophysical characterization ,Hydraulic properties ,Physical properties ,Rock forming components ,Anisotropy ,Rock matrix ,Heterogeneity ,Limestone ,Porosity - Abstract
In the framework of a wider European study of saline intrusions in coastal environments, the hydraulic behaviour of the rock matrix at the calcareous Campos site coastal aquifer (Majorca) has been characterized. This characterization is performed on rock cores in laboratory; its main objective is the relation between the hydraulic properties of the rock matrix and the rock forming components of petrophysical significance, specially the pore space structure. The anisotropy and heterogeneity is previously analyzed. The real and apparent density, effective and non-effective porosity, range of pore throat size, free and forced water absorption, water desorption, coefficient of capillarity and water vapour permeability have been evaluated. Seven different types of porosity according textural considerations have been established
- Published
- 2004
14. Caracterización petrológica de los morteros de la fuente prerrománica de Foncalada: tipos y origen
- Author
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Rojo Álvarez, Araceli, Mateos, F. J., and Valdeón Menéndez, Luis
- Published
- 2004
15. Aprovechamiento de las oleinas residuales procedentes del proceso de refinado de los aceites vegetales comestibles, para la fabricación de biodiesel
- Author
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Pereda Marín, Juan, Barriga Mateos, F., Álvarez-Mateos, María Paloma, and Universidad de Sevilla. Departamento de Ingeniería Química
- Subjects
Esterificación ,Transesterificación ,Acidulated soapstock ,Biodiesel ,Vegetable oils ,Fatty acid methyl esters ,Aceites vegetales ,Oleinas ,Metilesteres de ácidos grasos - Abstract
Se estudia un procedimiento para la obtención de Biodiesel a partir de las “Oleínas”. Biodiesel es un producto capaz de sustituir al combustible Diesel ordinario que se obtiene del petróleo y que consiste en una mezcla de ésteres metílicos de ácidos grasos. Las oleínas son unos residuos que resultan del proceso de refina- do de aceites vegetales para su uso alimentario y se componen de una mezcla de triglicéridos y ácidos grasos libres, con un con- tenido de estos últimos componentes superior al 50% . El merca- do de oleinas es fluctuante, con lo que en ocasiones surge el problema de su eliminación. Como resultado del trabajo efectua- do se define un proceso de obtención que consta de las siguien- tes etapas: 1. Esterificación de los ácidos libres de la Oleína con meta- nol, aplicando catálisis ácida, centrifugando el producto obtenido y separándolo de la fase metanol-ácido. En ésta etapa se obtiene un producto que contiene alrededor de un 70% de metil- esteres. 2. Transesterificación de los triglicéridos presentes en el producto esterificado con metanol, aplicando catálisis alcalina. El producto obtenido, previamente separado de la fase metanol- agua, contiene alrededor de un 90% de metil-esteres. 3. Purificación del producto resultante de las etapas 1 y 2 , por rectificación a vacío. El producto destilado tiene un contenido en metil-esteres superior al 98%. A procedure to obtain Biodiesel from “Oleinas” is studied. Biodiesel is a suitable product to replace diesel oil currently used to power the Diesel engines. It consists of a mixture of methyl esters of the fatty acids presents as triglycerides in vegetables oils (olive, sunflower, soya, rape oils). As a result of the refining of these oils for their use as food, a waste product is formed, the “oleinas” (acidulated soapstock). The oleinas consist of a mixture of triglycerides and free fatty acids, the latter amounting to 50% or more of the mixture and are subject to a fluctuating market, therefore it exist at times a problem for their disposal. In our research work we have tried to obtain biodiesel from oleinas. The process resulting from our experimental work is as follows: 1. Sterification of the free fatty acids with methanol, by acid catalysis, centrifuging the reaction product and removal of the acid-methanol phase. Drying of the latter. At this stage we have a product containing about 70% of methyl esters. 2. Transesterification of the triglycerides present in the sterified product with methanol by alkaline catalysis, washing the reaction product with a water methanol solution. Centrifuging and removal of the water-methanol phase. At this stage a biodiesel product is obtained containing about 90% of methyl esters. 3. Fractional vacuum distillation of the 90% biodiesel gives a final product with a methyl esters content higher than 98%.
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- 2003
16. Petrografía, por técnicas digitales, de las adiciones de Filler Calizo. Metodología
- Author
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Ángel Martínez, M. C., Martínez Murciano, J., Rodríguez Mateos, F., Carmona Guillén, F., and Prendes Rubiera, N.
- Subjects
Parámetros petrográficos ,Mármol ,Hormigón ,Tamaño de grano ,Filler - Abstract
This article describe the different stages in the processing of images obtained for characterizing several parameters of a calcareous filler (grain size, microfractography, etc). From the parameter Cx and C , we obtain a distance map to calculate the microfissuration of aggregate
- Published
- 1996
17. Determinación del índice de Huecos o «Air Void» en un Hormigón
- Author
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Ángel Martínez, M. C., Martínez Murciano, J., Rodríguez Mateos, F., Carmona Guillén, F., and Prendes Rubiera, N.
- Subjects
Proceso digital de imágenes ,Air Void ,Hormigón ,Hielo-deshielo - Abstract
Several characteristics of the dispered air bubbles in aerated concrete have been indicated as very im p o rta n t to the stu d y o f the fun ction o f en tra in ed air. This artic le describes the d iffe re n t stages in the processing o f images obtain ed fo r characterizing, among o th e r things, a functio n o f the a ir v o id ra tio, the highly variable dispersion of the parameters of spacing factor, the specific surface, the void frecuency, etc.. The results are compared with other methods, as Linear-transverse, using in the Standard test of ASTM C-457-90
- Published
- 1996
18. Reflexiones sobre la patología ocular
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Cuevas-Álvarez, J., Forteza-Vila, J., Hiscott, P., Proença, R., Dinarés-Fernández, M.C., Alfaro-Ferreres, L., Roselló-Sastre, E., Arce-Mateos, F., Camarasa-Lillo, N., Madrigal-Rubiales, B., López-Esteban, A., Fernández-Alonso, N., Pigazo-Merino, J.M., and Pastor-Jimeno, J.C.
- Published
- 2010
- Full Text
- View/download PDF
19. Niveles séricos de proteína catiónica del eosinófílo en pacientes con rinitis alérgica. Evolución tras tratamiento con corticoides
- Author
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Álvarez Gutiérrez, F.J., Valenzuela Mateos, F., Rodríguez Portal, J.A., Sánchez Gil, R., Tabernero Huguet, E., and Castillo Gómez, J.
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- 1997
- Full Text
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20. Estudio de calidad y selección de muestras de lavado broncoalveolar (LBA) en neumopatías difusas
- Author
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Martín Juan, J., Valenzuela Mateos, F., Soto Campos, G., Segado Soriano, A., Rodríguez Panadero, F., and Castillo Gómez, J.
- Published
- 1996
- Full Text
- View/download PDF
21. Mediadores de la inflamación (proteína catiónica del eosinófilo, ECP) en población normal y pacientes con asma bronquial o rinitis alérgica
- Author
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Álvarez Gutiérrez, F.J., Rodríguez Portal, J.A., Valenzuela Mateos, F., Capote Gil, F., Sánchez Gil, R., and Castillo Gómez, J.
- Published
- 1995
- Full Text
- View/download PDF
22. Macrófagos alveolares y radicales libres de oxígeno en las enfermedades pulmonares intersticiales difusas
- Author
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Sánchez, M.L., Martín, T., Barrios, M.N., Mateos, F., Jiménez, A., and Pérez Arellano, J.L.
- Published
- 1993
- Full Text
- View/download PDF
23. Metabolismo del ácido úrico en la enfermedad pulmonar obstructiva crónica (EPOC)
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Simon Rodriguez, A., Gomez-Fernandez, P., Anton Mateos, F., Rodriguez Ortega, J.E., Martin Perez, M.A., Nuñez Boluda, A., and Sanchez Agudo, L.
- Published
- 1985
- Full Text
- View/download PDF
24. Initial experience with thulium fiber laser for prostate enucleation: Analysis of the intraoperative and short-term outcomes in a prospective, multicenter cohort.
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Romero Otero J, Justo Quintas J, García Rojo E, Sopeña Sutil R, Peña Vallejo E, Lista Mateos F, Bozzini G, Saenz Calzada D, Rodríguez Antolín A, and García Gómez B
- Subjects
- Humans, Male, Aged, Prospective Studies, Treatment Outcome, Middle Aged, Time Factors, Laser Therapy methods, Lasers, Solid-State therapeutic use, Aged, 80 and over, Prostatic Hyperplasia surgery, Thulium therapeutic use, Prostatectomy methods
- Abstract
Introduction: Holmium laser enucleation of the prostate has rapidly become the gold standard for the surgical treatment of benign prostate hyperplasia, although thulium fiber laser (TFL) has also been postulated as an effective and safe alternative for prostate enucleation. The aim of this study is to describe our initial experience with the TFL for endoscopic enucleation of the prostate., Material and Methods: All patients proposed to TFL prostate enucleation were included in the analysis, regardless their prostate volume, catheter status and severity of symptoms, in 3 centers. Preoperative characteristics, intraoperative times and functional 3-months follow-up variables were collected, along with complications., Results: Fifty-six patients were available, with a mean age of 68.7 years. Enucleation and morcellation efficiencies were 2.04 and 7.47 g/min, respectively. Median hospital stay was one day. Comparable functional data, pre and 3-month post-surgery was: mean prostate volume 88.9 vs 21.3 g, maximum urinary flow 13.2 vs 27.3 ml/s, post-void residual volume 149 vs 7.8 ml, prostatic specific antigen level 11.2 vs 1 ng/ml, and International Prostate Symptom Score 20.75 vs 3.96. Fourteen out of 56 (25%) patients presented with complications grade ≤2, according to the Clavien-Dindo classification., Discussion: With wider evidence for other urological indications, very recent evidence about the suitability of TFL for prostate enucleation has arisen, since the first case described in 2021. Our results seem to back up these previous successful experiences as long as we obtained good intraoperative and short term follow-up functional results. However, there is still a need of longer follow-up data., Conclusions: TFL represents a novel technology for prostate enucleation, with a good intraoperative and short follow-up functional results, and a safety profile similar to the observed for those techniques that have been wider used for this indication. Further studies with longer follow-up periods and comparative with these other techniques are necessary., (Copyright © 2024. Published by Elsevier España, S.L.U.)
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- 2024
- Full Text
- View/download PDF
25. Drug Compounding for Diseases of the Oral Mucosa.
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Iglesias-Sancho M, Llambí Mateos F, and Salleras-Redonnet M
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- Drug Compounding, Excipients, Mouth Mucosa
- Abstract
Commercial topical medications for oral conditions are scarce and the vehicles used are not very suitable. Therefore, formulations containing active ingredients in vehicles specially designed for oral application must often be prepared. Drug compounding offers other advantages, including the possibility of combining several active ingredients in a single vehicle and prescribing drugs that are in short supply. In this article, we describe the main pharmaceutical formulations used to treat the most common diseases of the oral mucosa., (Copyright © 2020 AEDV. Publicado por Elsevier España, S.L.U. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
26. Salvage lymph node dissection in patients with prostate cancer treated with radical prostatectomy or radiotherapy and positive choline positron emission tomography (PET/CT) scan.
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Otta-Oshiro RJ, Lista-Mateos F, García-Mediero J, Arranz-Arija JA, García-Prado J, and Núñez-Mora C
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- Aged, Analysis of Variance, Androgen Antagonists therapeutic use, Antineoplastic Agents, Hormonal therapeutic use, Choline, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Neoplasm Recurrence, Local blood, Neoplasm Recurrence, Local diagnostic imaging, Progression-Free Survival, Prostate-Specific Antigen blood, Prostatic Neoplasms blood, Prostatic Neoplasms therapy, Retrospective Studies, Risk Factors, Treatment Outcome, Lymph Node Excision methods, Positron Emission Tomography Computed Tomography methods, Prostatectomy methods, Prostatic Neoplasms diagnostic imaging, Prostatic Neoplasms surgery, Salvage Therapy methods
- Abstract
Introduction and Objectives: Nodal prostate cancer recurrence is a challenging scenario. Current guidelines recommend the use of androgen deprivation therapy, tailored treatment or clinical trials. We studied the impact of Salvage lymph node dissection in selected patients., Material and Methods: We retrospectively reviewed records of 23 consecutive patients with prostate cancer and previous Radical prostatectomy or Radiotherapy who underwent SLND from December 2005 to November 2015., Results: We found that in patients that showed biochemical response the introduction of ADT was delayed 14.9 months compared to patients that did not responded (2.8 months) P=.00026. Furthermore although statistical significance was not reached (P=.072) PSA-DT could be a potential prognostic factor of radiological recurrence since patients with PSA-DT<6 months developed radiological recurrence 7.6 months earlier compared to their counterparts., Conclusions: Salvage lymph node dissection is a potential treatment that could delay ADT in selected patients., (Copyright © 2018 AEU. Publicado por Elsevier España, S.L.U. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF
27. Systematic review of kidney transplantation functional predictors.
- Author
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Miret Alomar E, Trilla Herrera E, Lorente Garcia D, Regis Placido L, López Del Campo R, Cuadras Solé M, Pont Castellana T, Moreso Mateos F, Serón Micas D, and Morote Robles J
- Subjects
- Forecasting, Humans, Treatment Outcome, Kidney physiology, Kidney Transplantation
- Abstract
Context: Kidney transplantation from donors with expanded criteria has increased the pool of kidneys at the cost of a higher risk of short and long-term graft dysfunction. The main issue lies in determining which kidneys will offer acceptable function and survival compared with the risk represented by surgery and subsequent immunosuppression., Objective: The objective of our article is to review the current evidence on the tools for predicting the functionality of kidney transplantation from cadaveric donors with expanded criteria and determining the validity for their use in standard practice., Acquisition of Evidence: We conducted a systematic literature review according to the PRISM criteria, through Medline (http://www.ncbi.nlm.nih.gov) and using the keywords (in isolation or in conjunction) "cadaveric renal transplantation; kidney graft function appraisal, graft function predictors". We selected prospective and retrospective series and review articles. A total of 375 articles were analysed, 39 of which were ultimately selected for review., Summary of the Evidence: The predictors of functionality include the following: The donor risk indices; the calculation of the renal functional weight or the assessment of the nephronic mass; the measurement of vascular resistances during perfusion in hypothermia; the measurement of the donor's biomarkers in urine and in the perfusion liquid; the measurement of functional and reperfusion parameters in normothermia; and the measurement of morphological parameters (microscopic and macroscopic) of the target organ. In this article, we present an explanatory summary of each of these parameters, as well as their most recent evidence on this issue., Discussion: None of the reviewed parameters in isolation could reliably predict renal function and graft survival. There is a significant void in terms of the macroscopic assessment of kidney transplantation., Conclusions: We need to continue developing predictors of renal functionality to accurately define the distribution of each currently available donor kidney., (Copyright © 2017 AEU. Publicado por Elsevier España, S.L.U. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
28. [Imaging diagnosis in Focal Therapy for prostate cancer: Multiparametric Magnetic Resonance Imaging].
- Author
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Lista Mateos F and Castillo Gallo E
- Subjects
- Humans, Image-Guided Biopsy, Male, Organ Sparing Treatments, Prostatic Neoplasms pathology, Magnetic Resonance Imaging methods, Prostatic Neoplasms diagnostic imaging, Prostatic Neoplasms therapy
- Abstract
The use of prostatic multiparametric MRI (mpMRI) has increased significantly over the last years, and has emerged as a crucial test for diagnosis, staging and treatment of prostate cancer (PCa). The use of the various available sequences (T2W, T1W, diffusion, perfusion and spectroscopy), as well as the different parameters they associate, not only enables to determine the group of patients subsidiary of focal ablative therapy, but also to perform a proper determination of the áreas to treat, as well as to monitor the development of therapy and to evaluate both oncological results and possible therapeutic failures. Despite the excellent results showed in the different studies, it is necessary to reach a consensus about its use on the different features associated with focal therapy, since it is a technique that requires not only large experience in its operation but also standardization. All this make it a complex technique and not free of difficulties in its interpretation.
- Published
- 2016
29. Safety and efficacy of outpatient biopsy in renal transplantation.
- Author
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Torres-Rodríguez IB, Castella-Fierro E, Serres-Creixans X, Salcedo-Allende M, Azancot-Rivero MA, Perelló-Carrascosa M, Sellares-Roig J, Cantarell-Aixandri C, Moreso-Mateos F, and Serón-Micas D
- Subjects
- Adult, Allografts, Contraindications, Cutaneous Fistula epidemiology, Cutaneous Fistula etiology, Female, Hemorrhage epidemiology, Hemorrhage etiology, Hospitalization, Humans, Kidney Diseases epidemiology, Kidney Diseases etiology, Male, Middle Aged, Surgery, Computer-Assisted, Ultrasonography, Interventional, Urinary Fistula epidemiology, Urinary Fistula etiology, Ambulatory Surgical Procedures adverse effects, Biopsy, Needle adverse effects, Kidney Transplantation, Transplants pathology
- Abstract
Background: In many centers patients are hospitalised to perform a renal allograft biopsy., Aim: To evaluate the safety and efficacy of outpatient renal allograft biopsies., Methods: Since December 2011 we perform renal allograft biopsies as an outpatient procedure. Exclusion criteria for performing an outpatient biopsy included: 1.) anticoagulant treatment, 2.) thrombocytopenia <50,000/mm3, 3.) body mass index >35kg/m2 and 4.) uncontrolled hypertension. The number and severity of complications were compared with an historical cohort of 124 biopsies done between 2007 and 2011 when all patients were hospitalised for the procedure and with 42 patients biopsied during hospitalisation between 2011 and 2013., Results: Between 2011 and 2013, 210 (95%) out of 230 biopsies indicated in the outclinic were performed as an outpatient procedure (95%). The incidence of major complications (bleeding requiring blood transfusion and/or embolisation) was 0.8% between 2007 and 2011 and 2.4% in biopsies between 2011 and 2013 in hospitalised patients (p=0.475). No major complications were observed in the outpatient biopsy group. Minor complications (hematuria, hematoma or fistula not requiring transfusion or embolisation) were also not different between groups (3.2%, 7.1% and 2.7%; respectively). Sample size adequacy according to the Banff criteria was not different among groups (p=0.052)., Conclusion: Ambulatory renal allograft biopsy is a safe and efficient procedure.
- Published
- 2014
- Full Text
- View/download PDF
30. Compounding as a current therapeutic option in dermatology.
- Author
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Sánchez-Regaña M, Llambí-Mateos F, Salleras-Redonnet M, Iglesias Sancho M, Collgros Totosaus H, and Umbert-Millet P
- Subjects
- Acne Vulgaris drug therapy, Humans, Psoriasis drug therapy, Rosacea drug therapy, Drug Compounding, Skin Diseases drug therapy
- Abstract
Compounding continues to play a key role in the treatment of skin conditions, despite the abundance of products made by the pharmaceutical industry. Right from the earliest days of dermatology, compounding proved very useful in the treatment of diseases for which no specific drugs were available. However, as new products came onto the market, this usefulness was called into question, and doubts over safety, stability, and effectiveness were raised. Today, compounding is regaining the place it once held in routine dermatological practice. We review the advantages and disadvantages of compounding, the most common indications, current legislation in our setting, and the latest developments in active ingredients and vehicles., (Copyright © 2011 Elsevier España, S.L. and AEDV. All rights reserved.)
- Published
- 2013
- Full Text
- View/download PDF
31. [Liver hydatidosis].
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Gentile F, Litvak E, Gay C, Mateos F, Salgueiro F, and Moscatelli G
- Subjects
- Adolescent, Female, Humans, Echinococcosis, Hepatic diagnosis
- Published
- 2010
- Full Text
- View/download PDF
32. [Reflexions on ocular pathology].
- Author
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Cuevas-Alvarez J, Forteza-Vila J, Hiscott P, Proença R, Dinarés-Fernández MC, Alfaro-Ferreres L, Roselló-Sastre E, Arce-Mateos F, Camarasa-Lillo N, Madrigal-Rubiales B, López-Esteban A, Fernández-Alonso N, Pigazo-Merino JM, and Pastor-Jimeno JC
- Subjects
- Ophthalmology, Pathology
- Published
- 2010
33. [Antiparasitic drugs. Review of the useful drugs in the treatment of classic and emergent parasitic diseases].
- Author
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Pérez JL, Carranza C, and Mateos F
- Subjects
- Animals, Antiparasitic Agents adverse effects, Antiparasitic Agents chemistry, Antiparasitic Agents classification, Antiparasitic Agents pharmacology, Antiparasitic Agents supply & distribution, Communicable Diseases, Emerging epidemiology, Endemic Diseases, Humans, Molecular Structure, Parasitic Diseases epidemiology, Spain epidemiology, Antiparasitic Agents therapeutic use, Communicable Diseases, Emerging drug therapy, Parasitic Diseases drug therapy
- Abstract
Introduction: In the 10 last years, the increase of international travels and immigration from low income countries to Spain was related with an increased of prevalence of parasitic diseases., Source: Critical review of the literature., Structure: Firstly, several general considerations were made on the antiparasitic drugs revised in this paper. Chemical structures and mechanisms of action of the main drugs with antiparasitic effect were considered in the second part of the review. Further, antiparasitic spectrum of selected drugs, main pharmacokinetical characteristics, usual posology, possible side effects and contraindications were detailed. Finally, some practical aspects, such as interactions and the methods for practical obtention of these drugs are indicated. This information is relevant because in Spain many anti-parasitic drugs may be obtained using non conventional methods., Conclusion: In Spain, the increase of parasitic diseases necessitates an update on antiparasitics drugs for their treatment.
- Published
- 2009
34. [Interferon in hepatitis B].
- Author
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García Buey L, González Mateos F, and Moreno Otero R
- Subjects
- Adenine administration & dosage, Adenine analogs & derivatives, Adenine therapeutic use, Antiviral Agents administration & dosage, Antiviral Agents adverse effects, Clinical Trials as Topic statistics & numerical data, Drug Therapy, Combination, Genotype, Guanine administration & dosage, Guanine analogs & derivatives, Guanine therapeutic use, Hepatitis B e Antigens analysis, Hepatitis B virus genetics, Hepatitis B virus immunology, Hepatitis B virus physiology, Hepatitis B, Chronic drug therapy, Humans, Interferon alpha-2, Interferon-alpha administration & dosage, Interferon-alpha adverse effects, Interferon-alpha pharmacology, Lamivudine administration & dosage, Lamivudine therapeutic use, Multicenter Studies as Topic statistics & numerical data, Nucleosides administration & dosage, Nucleosides therapeutic use, Organophosphonates administration & dosage, Organophosphonates therapeutic use, Polyethylene Glycols adverse effects, Polyethylene Glycols therapeutic use, Pyrimidinones administration & dosage, Pyrimidinones therapeutic use, Randomized Controlled Trials as Topic statistics & numerical data, Recombinant Proteins, Telbivudine, Thymidine analogs & derivatives, Treatment Outcome, Antiviral Agents therapeutic use, Hepatitis B drug therapy, Interferon-alpha therapeutic use
- Abstract
Hepatitis B virus (HBV) infection is a worldwide public health problem. There are an estimated 350 million persons with chronic HBV infection that could progress to cirrhosis and hepatocarcinoma with nearly one million deaths per year. In the last few years the therapeutic options in chronic hepatitis B have increased and currently six treatments are authorized: standard interferon (IFN)-alpha, pegylated interferon-alpha (PEG-IFNalpha), lamivudine, adefovir, entecavir, and telbivudine. For the last 25 years, conventional IFNalpha has been used as the treatment of chronic hepatitis B (CHB) and currently PEG-IFNalpha is indicated due to its greater effectiveness. Both drugs are first line options for HBeAg(+) and HBeAg(-) CHB. The advantages of IFNalpha and PEG-IFNalpha are that these drugs are administered for a limited time period, they achieve a higher sustained response rate and do not induce HBV mutants with antiviral resistance. These drugs achieve greater HBeAG and HBsAG clearance due to their antiviral and immunomodulatory activity. PEG-IFNalpha induces sustained biochemical and virological response in approximately one third of patients with HBeAg(+) CHB. The best response to IFNalpha and PEG-IFNalpha is obtained in patients with elevated transaminase levels, moderate viral load and HBV genotypes A and B. The disadvantages of IFNalpha and PEG-IFNalpha are their adverse effects and contraindications. These drugs cannot be administered in patients with decompensated cirrhosis. The combination of nucleos(t)ide analogs with PEG-IFNalpha could achieve much higher sustained response rates; however, which treatment constitutes the most suitable therapeutic strategy requires investigation.
- Published
- 2008
- Full Text
- View/download PDF
35. [Diarrhea with hypokalemia].
- Author
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Díaz Gonzálvez E, Romero Cordobés MM, González Mateos F, Bienvenido Navarro A, González Peramato P, and Bayo Berzoso A
- Subjects
- Aged, Antineoplastic Agents therapeutic use, Biopsy, Needle, Carcinoma, Neuroendocrine drug therapy, Carcinoma, Neuroendocrine pathology, Diarrhea drug therapy, Fatal Outcome, Humans, Hypokalemia drug therapy, Liver diagnostic imaging, Liver pathology, Liver Neoplasms drug therapy, Liver Neoplasms pathology, Male, Tomography, X-Ray Computed, Carcinoma, Neuroendocrine secondary, Diarrhea complications, Hypokalemia etiology, Liver Neoplasms secondary
- Published
- 2004
- Full Text
- View/download PDF
36. [Iron overload and chronic hepatitis C: the role of HFE gene mutations].
- Author
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García Buey L and González Mateos F
- Subjects
- Hemochromatosis Protein, Humans, Mutation, Hepatitis C, Chronic complications, Hepatitis C, Chronic genetics, Histocompatibility Antigens Class I genetics, Iron Overload complications, Iron Overload genetics, Membrane Proteins genetics
- Published
- 2003
37. [Immune lesion of hepatitis B].
- Author
-
García Buey L, González Mateos F, García Monzón C, and Moreno Otero R
- Subjects
- Acute Disease, Apoptosis, CD4-Positive T-Lymphocytes physiology, CD8-Positive T-Lymphocytes physiology, Cell Adhesion, Cytokines physiology, Hepatitis B pathology, Hepatitis B Antibodies physiology, Hepatitis B Surface Antigens immunology, Hepatitis B e Antigens immunology, Hepatitis B, Chronic immunology, Hepatitis B, Chronic pathology, Hepatocytes immunology, Hepatocytes pathology, Hepatocytes virology, Humans, Immunity, Cellular physiology, Immunity, Innate physiology, Killer Cells, Natural physiology, Lymphocyte Activation, Necrosis, Phagocytes physiology, Hepatitis B immunology, Hepatitis B virus immunology
- Published
- 2001
38. [Care for the menopausal woman: an objective to be developed from primary care].
- Author
-
Olazábal Ulacia JC, García Paniagua R, Montero Luengo J, García Gutiérrez JF, and Pastor Mateos F
- Subjects
- Female, Health Promotion organization & administration, Humans, Middle Aged, Spain, Menopause, Primary Health Care organization & administration, Women's Health Services organization & administration
- Published
- 2000
- Full Text
- View/download PDF
39. [Evaluation of 2 tuberculosis chemoprophylaxis regimens in patients infected with human immunodeficiency virus. The GECMEI Group].
- Author
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Martínez Alfaro EM, Cuadra F, Solera J, Maciá MA, Geijo P, Sánchez Martínez PA, Rodríguez Zapata M, Largo J, Sepúlveda MA, Rosa C, Sánchez L, Espinosa A, Mateos F, and Blanch JJ
- Subjects
- AIDS-Related Opportunistic Infections diagnosis, AIDS-Related Opportunistic Infections epidemiology, Adult, Antibiotics, Antitubercular administration & dosage, Antitubercular Agents adverse effects, Female, Humans, Incidence, Isoniazid administration & dosage, Isoniazid adverse effects, Liver drug effects, Male, Prospective Studies, Rifampin administration & dosage, Rifampin adverse effects, Time Factors, Tuberculin Test, Tuberculosis diagnosis, Tuberculosis epidemiology, AIDS-Related Opportunistic Infections prevention & control, Antitubercular Agents administration & dosage, Tuberculosis prevention & control
- Abstract
Objective: To assess the compliance, tolerance and efficacy of a short chemoprophylaxis regimen (IR) for tuberculosis using isoniazid (INH) plus rifampin (RIF) during 3 months versus a standard regimen (I) of isoniazid during 12 months in HIV positive patients., Material and Methods: Prospective, comparative, randomized and open clinical trial in four general hospitals and one prison hospital of Castilla-La Mancha. Prophylaxis was administered to PPD-positive patients and to anergic patients according to the CDC recommendations (1991). Patients were randomized in two treatment groups: regimen IR, isoniazid 300 mg daily and rifampin 600 mg daily; regimen I, isoniazid 300 mg during 12 months., Results: 133 patients were included, 64 to regimen I and 69 to regimen IR. Regimen IR had a better tolerance with a 28% of adverse effects versus 55% in regimen I. Hepatotoxicity was more frequent in regimen I with a RR = 2.2 (CI 95% 1.23-4.01). Severe hepatotoxicity leading to treatment withdrawal was related to drug administration time and was more frequent in the 12 months regimen group. Short regimen showed a better compliance, without significant differences. Tuberculosis incidence rate was a 4.23 cases/100 persons--year for regimen I and 2.08 in regimen IR, with a relative risk for developing tuberculosis with regimen IR group of 0.51 (CI 95% 0.09-2.8) versus regimen I group, without statistical significance. Prison stay was associated to a significant risk for tuberculosis, regardless of both regimens (RR = 9.2 CI 95%, 1.06-80.2)., Conclusions: In HIV-infected patients with PPD(+) or anergic, regimen with IR is at least as effective as regimen I for preventing the development of tuberculous disease, and has less adverse effects.
- Published
- 2000
- Full Text
- View/download PDF
40. [Acute cerebrovascular accident associated with drepanocytosis complicated by pneumococcal meningitis in two children].
- Author
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Mateos ME, López-Laso E, Simón R, and Mateos F
- Subjects
- Chronic Disease, Diagnosis, Differential, Female, Humans, Infant, Magnetic Resonance Imaging, Male, Severity of Illness Index, Tomography, X-Ray Computed, Anemia, Hemolytic complications, Brain blood supply, Brain diagnostic imaging, Brain pathology, Hemoglobin, Sickle biosynthesis, Meningitis, Pneumococcal complications, Meningitis, Pneumococcal diagnosis, Stroke complications, Stroke diagnosis
- Abstract
Introduction: Between 6% and 17% of the patients with drepanocytosis will have an acute cerebrovascular accident (ACVA). Precipitating factors have been described including bacterial meningitis, upper respiratory tract obstruction, dehydration, intense exercise, postoperatively, and hypoxia due to altitude., Clinical Cases: We report two Negro children with drepanocytosis who, at the ages of 8 and 20 months, had pneumococcal meningitis complicated by an ACVA. The 20 month old boy had been previously diagnosed as having drepanocytosis; the 8 month old girl was diagnosed when she was admitted to hospital with meningitis. In both cases the clinical features of the ACVA were focal epileptic seizures followed by hemiplegia. On cranial CT and MR regions of focal ischaemia of the hemisphere were observed. The boy of 20 months made an excellent recovery with no long term sequelae. The 8 month old girl had severe permanent sequelae: hemiparesia, blindness, mental deficiency and epileptic encephalopathy., Conclusions: We present two Negro children with drepanocytosis who had ischemic ACVAs, a common complication of the disease, during the course of pneumococcal meningitis but with very different clinical courses. Recent increases in immigration will mean that previously rare illnesses will be more commonly seen in our environment, and should be considered in the differential diagnosis.
- Published
- 2000
41. [Spinal cord infarction/ischemia].
- Author
-
Castro-Vilanova MD, de Toledo M, Mateos F, and Simón R
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Retrospective Studies, Spinal Cord blood supply, Spinal Cord pathology, Spinal Cord Ischemia diagnosis
- Abstract
Introduction: Vascular pathology is considered to be uncommon, with a much lower incidence than cerebral vascular pathology., Patients and Methods: We reviewed the clinical histories of patients with a clinical diagnosis of spinal cord infarction-ischemia attended by the Neurology Department and the Neuropaediatric section at our centre between 1990 and 1997. We analyzed the clinical and investigational findings and compared them with those in the literature., Results: We studied the cases of 12 patients (nine adults and three children). There was only one case in which no etiological factor of any type was found to justify the spinal vascular condition. All the children had had surgery to repair coarctation of the aorta. The most frequent clinical presentation was of paraparesis-paraplegia with signs of involvement of the anterior spinal artery. MR was done in all cases, except in that of an adult who was diagnosed on arteriography. The adults were studied by means of MR during the first 24-48 hours after onset of the condition. In five cases this was normal. In two of the latter cases, MR was repeated and alterations were seen in one whilst the other was not satisfactory. In the other three cases MR was not repeated since in two there was clinical improvement and in the other excessive technical problems. On discharge the children had not improved at all although the six adults improved completely or almost completely., Conclusions: In general, our findings are comparable to those in the literature. We consider that the diagnosis is basically clinical and differential diagnosis should be made with other spinal disorders. MR is helpful, although early use does not show changes which help in diagnosis.
- Published
- 1999
42. [Estimation of the neurologic demand in a health care area of Madrid, Spain (area 11, University Hospital, 12 of October)].
- Author
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Bermejo F, Calandre L, Morales MA, Gutiérrez-Rivas E, Mateos F, Molina JA, Alvarez-Tejerina JA, Trueba J, Porta J, González C, Alberquilla A, and Vallejo AR
- Subjects
- Catchment Area, Health, Female, Hospitals, University, Humans, Male, Referral and Consultation, Spain, Health Services statistics & numerical data, Health Services Needs and Demand statistics & numerical data, Neurology
- Abstract
Objectives: To analyse the demand for neurologic care and the neurological resources in a health district., Patients and Methods: Demographic, medical care aspects, neurologic care demands and neurological resources of the health district 11 of Madrid (University Hospital "12 de Octubre"), referred to 1996, were reviewed., Results: The rate of aging (17%) and the consulting rates in the National Health System (86%) versus private care were high in this health district. The neurologic care demands were 17.5-18.1 and 36 consultations respectively per 1,000 inhabitants/year. There were 2 patient-care neurologists and 3.7 neurologic beds per 100,000 inhabitants., Conclusions: The neurologic care was considered high and with a tendency to increase. The available neurological resources were judged to be insufficient.
- Published
- 1999
43. [Hemolytic anemia associated with indinavir administration].
- Author
-
Mateos F, Tarraga I, Blanch JJ, Martínez E, and Solera J
- Subjects
- Adult, Humans, Male, Anemia, Hemolytic chemically induced, HIV Protease Inhibitors adverse effects, Indinavir adverse effects
- Published
- 1999
44. [Gamma-sarcoglycanopathy:two new cases in a gypsy family family in Spain].
- Author
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García-Morales I, Galán L, Mateos F, Simón R, Morales P, Cabello A, and Gómez-Escalonilla C
- Subjects
- Biopsy, Cell Membrane metabolism, Cell Membrane pathology, Child, Preschool, Creatine Kinase blood, Cytoskeletal Proteins metabolism, Dystrophin deficiency, Electromyography methods, Gene Expression genetics, Humans, Male, Membrane Glycoproteins metabolism, Muscle, Skeletal pathology, Muscle, Skeletal physiopathology, Muscular Dystrophies metabolism, Muscular Dystrophies physiopathology, Point Mutation genetics, Spain, X Chromosome genetics, Cytoskeletal Proteins genetics, Membrane Glycoproteins genetics, Muscular Dystrophies genetics, Roma
- Abstract
Introduction: Included under the heading of limb girdle muscular dystrophy is a heterogeneous group of myopathies which share the same phenotype characteristics. The illness is of early onset, progressive and basically involves muscles of the shoulder and pelvic girdles. Recent identification of muscle proteins and the genes which codify them has led to new classification of these conditions according to their genetic characteristics. It is currently accepted that there are two major groups: the dominant and recessive forms. The latter includes type 2C limb girdle muscular dystrophy associated with chromosome 13, where the gene for gamma-sarcoglycan is found. This protein belongs to the glycoprotein complex associated with dystrophin. Recently a new mutation has been identified, the C283Y, exclusive to the Gypsy race, which affects this gene and therefore the alterations in gamma-sarcoglycan produced by it., Clinical Case: We describe two patients, Gypsy brothers, who complained of myopathy, which they had had for some years, compatible with this condition and in whom the C283Y mutation had recently been detected., Conclusions: We describe another Spanish Gypsy family, all members of which have the characteristic mutation. We emphasize the importance of genetic studies in all cases of myopathy which have not been fully diagnosed.
- Published
- 1999
45. [Spinal tumors in infancy. A report of 48 cases].
- Author
-
Pérez-Martínez DA, Bueno HJ, Gutiérrez F, López-Laso E, Puente-Muñoz AI, Esparza J, Simón R, and Mateos F
- Subjects
- Adolescent, Astrocytoma complications, Back Pain diagnosis, Back Pain etiology, Child, Child, Preschool, Diagnosis, Differential, Ependymoma complications, Female, Humans, Infant, Infant, Newborn, Lipoma complications, Magnetic Resonance Imaging, Male, Movement Disorders diagnosis, Movement Disorders etiology, Retrospective Studies, Sarcoma complications, Spinal Neoplasms complications, Astrocytoma pathology, Ependymoma pathology, Lipoma pathology, Sarcoma pathology, Spinal Neoplasms pathology
- Abstract
Introduction: Spinal tumours in infancy are an infrequent oncological disorder. The clinical features, usually of insidious onset, are alterations in gait and a painful spine., Objective: To analyze the different histological types of spinal tumours seen in infancy and their form of presentation in our series., Patients and Methods: We reviewed the clinical histories of 48 patients with intraspinal tumours, aged under 15 years, whose reports of histological diagnosis had been sent to our centre., Results: Of the patients studied, 17 were girls (35.4%) and 31 boys (64.6%) with an average age of 7.7 years. The histological diagnoses made most frequently were astrocytomas (22.9%) and lipomas (18.8%) followed by metastases (12.5%), ependymomas (8.3%) and Edwing's sarcoma (8.3%). The clinical features were present prior to diagnosis for between 1 and 6 months in 13 patients, and for less than one month in 9 patients. The presenting symptoms were alterations in gait and back pain in most patients. Exploratory tests were related to the involvement of long vias and second motor-neurone lesions. The main topographical findings were: in the axial plane the lesions were extradural (23 patients) and in the sagittal plane there was dorsal involvement (34 patients)., Conclusions: Insidious, progressive alterations in gait together with continuous, nocturnal back pain are valuable data when a serious spinal disorder is to be suspected. Early diagnosis should be based on neuroimaging tests, essentially MR, in the patients in whom spinal cord involvement is considered.
- Published
- 1999
46. [Vascular malformations of the central nervous system in children].
- Author
-
López-Laso E, Mateos ME, Pérez-Martínez DA, Gutiérrez-Martín F, Bueno JH, Simón R, Mateos F, Muñoz MJ, and Muñoz A
- Subjects
- Adolescent, Catchment Area, Health, Cerebral Angiography, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Intracranial Arteriovenous Malformations epidemiology, Magnetic Resonance Imaging, Male, Retrospective Studies, Spain, Intracranial Arteriovenous Malformations diagnosis
- Abstract
Objective: To present the experience of vascular malformations (VM) of the central nervous system (CNS) in children obtained in our centre. Since these lesions do not often present clinically in childhood, there are few series described in the literature., Patients and Methods: We made a retrospective review of the clinical histories of patients with VM of the CNS shown on MR, angiography and/or morbid anatomy, who were aged 15 years or under. Patients with Sturge-Weber or Von Hippel-Lindau syndromes were excluded., Results: We describe 32 patients with VM of the CNS. Twenty four had arteriovenous malformations (AVM), 5 had cavernous malformations (CM), 2 had malformations of Galeno's vein (MGV) and one patient had a congenital fusiform arterial aneurysm. Twenty two children (68%) presented clinically with hemorrhages. This was the form of presentation in 20 patients with AVM. In 4 of the 5 patients with CM the first sign was epileptic crisis. The two patients with MGV presented with macrocephaly, in one neonate it was associated with heart failure and in on older baby with hydrocephaly. The patient with a congenital arterial aneurysm presented with paroxystic episodes of facial pain., Conclusions: The AVM are the VM which most frequently cause symptoms in childhood.
- Published
- 1999
47. [Polymyositis in childhood].
- Author
-
Marín J, Noguera F, Cabello A, and Mateos F
- Subjects
- Adrenal Cortex Hormones therapeutic use, Biopsy, Child, Child, Preschool, Electromyography, Female, Humans, Infant, Male, Muscle, Skeletal innervation, Muscle, Skeletal pathology, Polymyositis drug therapy, Polymyositis pathology
- Abstract
Introduction and Objective: Idiopathic inflammatory myopathies are very rare in infancy. We present five cases of polymyositis in children in which the clinical variability and difficulty in diagnosis that occurs with this disorder are clearly seen, and analyze their response to steroid treatment., Clinical Cases: We can distinguish two groups of patients: the first is formed of the case of a two and a half month old baby with generalized hypotonia; and the second includes the other four cases, children of between 2 and 8 years old with weakness, which was mainly proximal. One of the second group later developed juvenile chronic arthritis. In all cases there was a raised CPK and a myopathic EMG, with or without spontaneous muscle activity. Muscle biopsy showed inflammatory myopathy. The first group corresponds to so-called infantile polymyositis which is characterized by generalized hypotonia. The second group includes older children in whom the clinical features of the disorder are similar to those in adults. The association of other autoimmune diseases with infantile polymyositis is exceptional. All cases show more or less improvement with corticosteroids., Conclusions: The polymyositis are extremely rare before puberty and have a broad clinical spectrum. Congenital cases have been described in infants and in older children. The biopsy results are usually unexpected. Treatment with corticosteroids leads to clinical improvement which may be only partial and is less favorable than in the dermatomyositis.
- Published
- 1999
48. [Comments on the article: "Ophthalmoplegia-ataxia-areflexia in pediatrics. 3 new cases and a review of the literature"].
- Author
-
Benito-León J, Mateos F, and Simón R
- Subjects
- Adolescent, Humans, Infant, Male, Miller Fisher Syndrome diagnosis
- Published
- 1999
49. [Ischemic stroke in children].
- Author
-
Benito-León J, Guerrero AL, Simón R, and Mateos F
- Subjects
- Adolescent, Cerebrovascular Disorders etiology, Child, Child, Preschool, Female, Humans, Infant, Male, Retrospective Studies, Spain epidemiology, Cerebrovascular Disorders epidemiology
- Abstract
Objective: Ischemic stroke in children and infants is a rare condition. We present a series of 23 pediatric patients of ischemic stroke., Patients and Methods: A retrospective series of 23 patients, aged between 1 month and 13 years, diagnosed by anamnesis, clinical examination and neuroimaging. The clinical picture, neuroimaging findings, etiology, evolution and sequelae are evaluated., Results: Eighteen of the patients had an ischemic stroke in the carotid territory (78.3%) and 5 in the vertebro-basilar (21.7%). Idiopathic (30.4%), cardiopathy (21.7%) and migraine (17.4%) were the most frequent etiologies. The recovery was complete in 9 patients (39.1%). There was a death as a result of systemic complications caused by dehydration (4.3%), and 13 patients (56.6%) were disabled: 6 with hemiparesis of diverse grades, 5 with epilepsy and hemiparesis, one with epilepsy, and one with mental retardation., Conclusions: Ischemic stroke in children and infants is an unusual entity. The causes are multiple, although there is an elevated percentage of idiopathic cases. In our series, we highlight the significative percentage of vertebro-basilar strokes and the finding of three unusual etiologies in ischemic stroke in childhood, such as migraine, Mycoplasma pneumoniae infection and smallpox.
- Published
- 1998
50. [New antiviral agents in chronic viral hepatitis].
- Author
-
Gómez Cedenilla A, Zapater Hernández P, García Buey L, Abad Santos F, García Monzón C, González Mateos F, and Moreno Otero R
- Subjects
- Humans, Antiviral Agents therapeutic use, Hepatitis, Chronic drug therapy, Hepatitis, Viral, Human drug therapy
- Published
- 1998
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