1. Effectiveness of omega-3 fatty acid supplementation in patients with Alzheimer disease: A systematic review and meta-analysis.
- Author
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Araya-Quintanilla F, Gutiérrez-Espinoza H, Sánchez-Montoya U, Muñoz-Yañez MJ, Baeza-Vergara A, Petersen-Yanjarí M, and Fernández-Lecaros L
- Subjects
- Humans, Randomized Controlled Trials as Topic, Alzheimer Disease drug therapy, Cognitive Dysfunction drug therapy, Dietary Supplements, Fatty Acids, Omega-3 administration & dosage
- Abstract
Introduction: Alzheimer disease (AD) is a neurodegenerative disease characterised by progressive dementia associated with global cognitive dysfunction., Methods: We conducted a systematic review and meta-analysis of clinical trials evaluating omega-3 supplementation in patients with AD., Objective: To determine if there is scientific evidence of the effectiveness of omega-3 supplementation in improving cognitive function in patients with AD., Search Strategy: We included only randomised controlled trials (RCTs) from the following databases: Medline, Cochrane Central, Cinahl, and LILACS. An electronic search was also conducted using Google Scholar., Study Selection: Six articles met the eligibility criteria. The risk of bias was assessed following the Cochrane method., Conclusion: There is no consistent evidence to support the effectiveness of omega-3 supplementation in improving cognitive function in AD patients in the short and medium term., (Copyright © 2017 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.)
- Published
- 2020
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