1. [Effect of isoproterenol on the liberation of histamine from rat lung mast cells].
- Author
-
Vieytes MR, Louzao MC, de la Cruz LF, and Botana LM
- Subjects
- Animals, Calcimycin pharmacology, Calcium pharmacology, Concanavalin A pharmacology, Drug Interactions, Mast Cells metabolism, Rats, Receptors, Adrenergic, beta drug effects, Receptors, Adrenergic, beta physiology, Sodium Fluoride pharmacology, p-Methoxy-N-methylphenethylamine pharmacology, Histamine Release drug effects, Isoproterenol pharmacology, Lung cytology, Mast Cells drug effects
- Abstract
Rat lung mast cells were stimulated with drugs with distinct mechanisms of action, namely concanavalin A, compound 48/80 ionophore A23187, in the presence of the beta adrenergic agonist (-)isoproterenol. Cells show a high response when they are stimulated with FNa-calcium. Isoproterenol does not inhibit histamine release induced by any stimuli, but enhances the response to concanavalin A and compound 48/80. Results point to the lack of beta activity on rat lung mast cells.
- Published
- 1991