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The authors present a clinical and documented follow up on the peri-lesion skin in 44 venal blood vessel ulcers which were treated by a hyper-oxygenized fatty acid emulsion. All the elderly in this study belonged to the Number 3 Health Department of the Valencia Sanitary Council. This study's protocol and its data collection register received a favourable report from the Committee on Research Ethics at the "La Plana" Hospital. With a total percentage of 60 in essential linoleic fatty acid, CORPITOLINOL 60, is the emulsion which has the greatest quantity of this element so necessary for human skin. In effect, this is the essential fatty acid which has the greatest presence in human skin, besides being a vital element for skin hydration and its viability to form part of a fundamental structure: intercellular layers in the corneum layer of the epidermis. On the other hand, in the hyper-oxygenation process, this product helps the skin to obtain molecules very similar to prostaglandins land 2 which favour tissue perfusion. The main objective of this study has been to evaluate, after the application of this emulsion over a four week time period, the reduction of erythema and peri-lesion hyperkeratosis in venal blood vessel ulcers. But at the same time, as a secondary objective, this study evaluated peri-lesion skin based on other criteria such as pruritus, lesions due to scratching, or edema; this study verified whether treatment of peri-lesion skin influences the cicatrisation of wounds, as well as treatment acceptance by health professionals and patients. Incidences of erythemas and hyperkeratosis totally disappeared in 40% and 50% of those cases, respectively; in those lesions where these symptoms continued after four weeks of treatment there was a significant reduction in the degree of both erythemas and hyperkeratosis, 25% in each case. These researchers consider that good treatment of peri-lesion skin combined with a standard cure protocol, using "Urgotul" as the primary dressing, helped to achieve an overall 45% cicatrisation rate plus an 80% total cicatrized surface area. To these results, these researchers noted fine tolerance for the treatment employed and a very high acceptability level for this treatment by health professionals. To sum up, the analysis of the results of this clinical study prove the efficiency of "Corpitol Emulsion"; in addition, its fine tolerance and its high acceptability level make this product adaptable to the treatment of venal blood vessel ulcers in lower limbs when these ulcers are caused by varicose veins or a have a mixed cause with varicose veins as a predominant factor.

Conjugated linoleic acid (CLA) is a group of positional and geometric isomers of linoleic acid. The major dietary sources of CLA are meat from rumiants and dairy products. There are also foods enriched in CLA (by modification animal feed or addition of commercial CLA from cartamo oil). However, the major isomer of CLA in natural food is cis-9,trans-11 and commercial CLA contains approximately equal amounts of cis-9,trans-11 and trans-10,cis-12 isomers. Although CLA is minor component of the diet, at present CLA has provoked intense scientific research accompanied by an advertising boom. This is due to the potential health effects demonstrated in animal and cell culture experiments including effects on body composition, specially a reduction in body fat mass and anticarcinogenic, antidiabetogenic and immune modulating effects. The results obtained in human volunteers are limited and even sometimes contradictory. This review focuses on recently studies in humans. To draw conclusions on CLA's potential interest as a functional ingredient, additional studies are needed to clearly define optimal level of CLA intake, short and long term effects and side effects of each individual CLA isomer in order to determine its safety and efficacy.