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Introduction and Objectives: There are scarce data on the optimal duration and prognostic impact of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) with second-generation drug-eluting stents for left main coronary artery (LMCA) disease. The aim of this study was to investigate the practice pattern and long-term prognostic effect of DAPT duration in patients undergoing PCI with second-generation drug-eluting stents for LMCA disease., Methods: Using individual patient-level data from the IRIS-MAIN and KOMATE registries, 1827 patients undergoing PCI with second-generation drug-eluting stents for LMCA disease with valid information on DAPT duration were included. The efficacy outcome was major adverse cardiovascular events (MACE, a composite of cardiac death, myocardial infarction, and stent thrombosis) and the safety outcome was TIMI major bleeding., Results: DAPT duration was <6 months (n=273), 6 to 12 months (n=477), 12 to 24 months (n=637), and ≥ 24 months (n=440). The median follow-up duration was 3.9 [interquartile range, 3.01-5.00] years. Prolonged DAPT duration was associated with lower incidences of MACE. In multigroup propensity score analysis, adjusted HR for MACE were significantly higher for DAPT <6 months and DAPT 6 to 12 months than for DAPT 12 to 24 months (HR, 4.51; 95%CI, 2.96-6.88 and HR 1.92; 95%CI, 1.23-3.00). There was no difference in HR for major bleeding among the assessed groups., Conclusions: DAPT duration following PCI for LMCA disease is highly variable. Although the duration of DAPT should be considered in the context of the clinical situation of each patient, <12 months of DAPT was associated with higher incidence of MACE. Registration identifiers: NCT01341327; NCT03908463., (Copyright © 2022 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.)

Objective: To show the information obtained in U.S. surveys and studies on cigarette smoking or other tobacco use in Mexicans residing in the United States., Material and Methods: Different information systems and surveys were used. Those used in the study herein presented include the Youth Risk Behavior Survey, 1991-2001, the National Survey on Drug Use and Health, 1999-2001, the National Health Interview Survey, 1978-2001, the Current Population Survey, 1998-1999, The National Health Vital Statistics, 1999, and the U.S. Census Bureau, 2001., Results: A decreased prevalence of cigarette smoking has been observed in the U.S. both in young persons and adults. A decreased prevalence among subjects reporting Mexican and Mexican-American (combined) ethnicity was also noted. Young adults and adults of Mexican or Mexican-American origin smoke cigarettes less frequently than non-Hispanic whites or American Indians. However, this lower rate among Mexicans and Mexican-Americans is due mainly to the lower use of cigarettes among Mexican-American and Mexican women (combined). Although these women have a lower prevalence of cigarette smoking than non-Hispanic white females, among Mexican-American and Mexican males (combined) cigarette smoking may be as common as in non-Hispanic white males. Moreover, those who identify themselves as Mexican-American have higher cigarette use than those who identify themselves as Mexicans. Finally, Mexican and Mexican-American women (combined) of a lower education level are more prone to smoking during pregnancy than females of the same group with a higher education level., Conclusions: This report shows differences by age, sex, self-definition of ethnicity (Mexican or Mexican-American), and education level, regarding smoking among Mexicans or persons with a Mexican background living in the United States. It is crucial to understand the demographic changes and trends and patterns among Mexicans and Mexican-Americans in the U.S. so as to design and implement smoking control programs that are efficient, culturally sensitive, and designed specifically for Mexicans and Mexican-Americans. The English version of this paper is available at: http://www.insp.mx/salud/index.html.