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Start Over Descriptor "Lateral hypothalamus" Language spanish; castilian
2 results on '"Lateral hypothalamus"'

1. Mapping the populations of neurotensin neurons in the male mouse brain.

Author

Schroeder LE, Furdock R, Quiles CR, Kurt G, Perez-Bonilla P, Garcia A, Colon-Ortiz C, Brown J, Bugescu R, and Leinninger GM

Subjects
Animals, Atlases as Topic, Male, Mice, Inbred C57BL, Mice, Transgenic, Neurotensin genetics, Brain metabolism, Neurons metabolism, Neurotensin analysis
Abstract

Neurotensin (Nts) is a neuropeptide implicated in the regulation of many facets of physiology, including cardiovascular tone, pain processing, ingestive behaviors, locomotor drive, sleep, addiction and social behaviors. Yet, there is incomplete understanding about how the various populations of Nts neurons distributed throughout the brain mediate such physiology. This knowledge gap largely stemmed from the inability to simultaneously identify Nts cell bodies and manipulate them in vivo. One means of overcoming this obstacle is to study Nts Cre mice crossed onto a Cre-inducible green fluorescent reporter line (Nts Cre ;GFP mice), as these mice permit both visualization and in vivo modulation of specific populations of Nts neurons (using Cre-inducible viral and genetic tools) to reveal their function. Here we provide a comprehensive characterization of the distribution and relative densities of the Nts-GFP populations observed throughout the male Nts Cre ;GFP mouse brain, which will pave the way for future work to define their physiologic roles. We also compared the distribution of Nts-GFP neurons with Nts-In situ Hybridization (Nts-ISH) data from the adult mouse brain. By comparing these data sets we can distinguish Nts-GFP populations that may only transiently express Nts during development but not in the mature brain, and hence which populations may not be amenable to Cre-mediated manipulation in adult Nts Cre ;GFP mice. This atlas of Nts-GFP neurons will facilitate future studies using the Nts Cre ;GFP line to describe the physiological functions of individual Nts populations and how modulating them may be useful to treat disease., (Copyright © 2019 Elsevier Ltd. All rights reserved.)

Published
2019
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2. El sistema orexinérgico/hipocretinérgico y su rol en los trastornos del sueño

Author

Valencia A, Mauricio H, Cassiani M, Carlos A, Cardona O, Juan C, and Villalobos Talero, Julio

Subjects
Orexins, hipotálamo lateral, narcolepsia, sleep disorders, narcolepsy, lateral hypothalamus, Orexinas, trastornos del sueño
Abstract

Las orexinas o hipocretinas son neuropéptidos recientemente descritos (1998), encontrados en mayor densidad en neuronas de las regiones lateral, posterior y perifornical del hipotála-mo, las cuales se han visto implicadas en procesos de modulación de la ingesta alimenticia y del ciclo sueño-vigilia. El sistema orexinérgico tiene amplias proyecciones a todo lo largo y ancho del SNC especialmente a centros monoaminérgicos, tales como el locus coeruleus, núcleo tuberomamilar, núcleos del rafé y el área tegmental ventral. Inicialmente se pensó en un papel fundamental de las orexinas en la regulación de la función alimenticia, sin embargo estudios recientes han implicado a estos neuropéptidos en la regulación del ciclo sueño-vigilia. Estos hallazgos permiten conocer mejor una región como el hipotálamo, al igual que brinda un mejor entendimiento de la patogenia y fisiopatología relacionadas con los trastornos de la alimentación y el sueño. Este artículo pretende presentar una revisión lo más completa posible de lo que se conoce hasta ahora de estos neuromoduladores y su papel en relación con los trastornos del sueño, especialmente su implicación en la narcolepsia. Orexins or hypocretins are recently described (1998) neuropeptides found in greater density in hypothalamic neurons, wich have been shown to be important for modulating feeding and sleep-wakefulness cycle. Orexinergic system has broad projections throughout the length and breadth of the CNS specially to monoaminergic centers such as the locus coeruleus, tuberoamilar neclei, raphe nuclei, and ventral tegmental area. Initially it was thought a key role of orexin in feedin behavior regulation, however, recent studies give a leading role to these neuropeptides in regulating the sleep-wakefulness cycle, this discovery opens a door to help better understand the operation of an area so important for the homeostasis of the human body, such as the hypothalamus, and gives some basis for a better understanding of the pathogenesis and pathophysiology in relation to eating disorders and sleep. The aim of this paper is to provide an updated review of the morphological and functional aspects that are known so far in relation to these molecules and their relationship with sleep disorders, especially their involvement in narcolepsy.

Published
2010

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