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Your search keyword '"Ignacio Aldana"' showing total 2 results
Start Over Author "Ignacio Aldana" Language spanish; castilian
2 results on '"Ignacio Aldana"'

1. New antagonist agents of neuropeptide y receptors

Author

Ignacio Aldana, Isabel Rivero, Argimiro Rivero, Patricio Huenchuñir, Carmen Frigola, Maria Luisa Alonso, Antonio Monge, D. H. Caignard, and P. Renard

Subjects
obesity, energy metabolism, weight reduction, neuropeptide Y, Chemistry, QD1-999
Abstract

In the CNS, NPY has been implicated in obesity and feeding, endocrine function and metabolism. Potent and selective rNPY antagonists will be able to probe the merits of this approach for the treatment of obesity. We report the synthesis and preliminary evaluation of some hydrazide derivatives as antagonists of rNPY.

Published
2000
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2. An easy and direct method for the synthesis of 1,2,4-triazole derivatives through carboxylic acids and hydrazinophthalazine

Author

Gildardo Rivera, Virgilio Bocanegra-Garcia, Antonio Moreno, Silvia Galiano, Silvia Pérez, Ignacio Aldana, and Antonio Monge

Subjects
1,2,4-triazoles, carboxylic acids, hydrazinophthalazine, Chemistry, QD1-999
Abstract

We have developed an easy method for the synthesis of thirteen compounds derived from 1,2,4-triazoles through a carboxylic acid and hydrazinophthalazine reaction, with a 75-85% yield mediated by the use of agents such as 1-ethyl-3-(3'-dimethylaminopropyl)-carbodiimide hydrochloride and 1-hydroxybenzotriazole. The operational simplicity of this method and the good yield of products make it valuable for the synthesis of new compounds with pharmacological activity.

Published
2008
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