1. [Is there life after teduglutide?]
- Author
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Martínez Martínez AL, Calles Romero LA, Etxeberría Martín E, Monasterio Jiménez O, Zabalegui Eguinoa A, Paja Fano M, Monzón Mendiolea A, Cadenas González A, Cabriada Nuno JL, and Iglesias Hernández NC
- Subjects
- Crohn Disease therapy, Fluid Therapy, Humans, Jejunostomy, Liraglutide therapeutic use, Male, Middle Aged, Parenteral Nutrition, Product Recalls and Withdrawals, Gastrointestinal Agents adverse effects, Gastrointestinal Agents therapeutic use, Intestinal Diseases drug therapy, Peptides adverse effects, Peptides therapeutic use, Short Bowel Syndrome drug therapy
- Abstract
Introduction: Intestinal failure (IF) is defined as a reduction in intestinal function below the minimum necessary for the absorption of nutrients, requiring intravenous supplementation to maintain health and/or growth. The most common cause is short bowel syndrome (SBS). Approximately 50% of patients with SBS have IF and require parenteral support. Teduglutide is a human glucagon-like peptide-2 analogue (GLP-2) approved for the treatment of patients with SBS. Clinical trial results have proven its efficacy by reducing volume and days of administration of parenteral nutrition and fluid therapy. Few publications evaluate the effects on long-term bowel function in respondent patients after teduglutide suspension. A patient with type I SBS (terminal jejunostomy) due to multiple surgeries for Crohn's disease, who was treated with liraglutide for one year and sequential teduglutide for 21 months, is described. With the former, a reduction in the need for contribution and debit by jejunostomy was observed. The GLP-2 analogue achieved a greater reduction in the hydric disbalance that allowed the suspension of the nocturnal suerotherapy, with weight gain and maintenance of nutritional parameters; situation maintained two years after its suspension.
- Published
- 2020
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