1. [Gentamicin pharmacokinetics in term newborn: ¿Is it necessary to systematically monitor plasmatic levels?].
- Author
-
Telechea H, Gesuele J, Grosso P, Galarraga F, Guzzo F, Speranza N, Antúnez F, Nanni L, and Giachetto G
- Subjects
- Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents blood, Drug Monitoring, Female, Gentamicins administration & dosage, Gentamicins blood, Humans, Infant, Newborn, Infusions, Intravenous, Male, Retrospective Studies, Anti-Bacterial Agents pharmacokinetics, Gentamicins pharmacokinetics
- Abstract
Background: Gentamicin is indicated as empiric treatment for neonatal sepsis. Plasmatic levels dosification of gentamicin is a common practice. The relationship between peak plasma concentration (Cmáx) with minimum inhibitory concentration (MIC) (Cmáx/MIC) is the parameter that best predicts treatment efficacy., Aim: To determine pharmacokinetics of gentamicin in term newborn infants., Methods: Term newborn infants receiving gentamicin, without critical illness in which plasmatic levels of gentamicin was performed were included. Elimination clearance (Cl) elimination half-life (t½) and volume of distribution (Vd) were calculated. In each case the value of Cmax/MIC parameter was calculated, considering a MIC value of 1 μg/mL for Escherichia coli., Results: Thirteen newborns were included. The mean PK values were Cl: 0.26 mL/hour, Vd: 0.54 L/kg and t½: 6.8 h. Cmax/MIC was > 8 in 6 newborns., Conclusions: Pharmacokinetic parameters of gentamicin are predictable in term newborn infants. With gentamicin doses normally used Cmax/MIC values reached 8 in 6 newborns. It is necessary to review the usefulness of plasma drug monitoring and gentamicin dosage in this group of newborns.
- Published
- 2016
- Full Text
- View/download PDF