1. [Chronobiological aspects of obesity and metabolic syndrome].
- Author
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Gómez-Abellán P, Madrid JA, Ordovás JM, and Garaulet M
- Subjects
- ARNTL Transcription Factors genetics, ARNTL Transcription Factors physiology, Adiponectin genetics, Adiponectin physiology, Adipose Tissue physiopathology, Animals, Cardiovascular Diseases epidemiology, Cardiovascular Diseases etiology, Chronotherapy, Cryptochromes genetics, Cryptochromes physiology, Female, Gene Expression Regulation physiology, Humans, Jet Lag Syndrome physiopathology, Leptin physiology, Male, Mammals physiology, Metabolic Syndrome epidemiology, Metabolic Syndrome therapy, Neoplasms epidemiology, Neoplasms etiology, Obesity epidemiology, Obesity therapy, PPAR gamma genetics, PPAR gamma physiology, Period Circadian Proteins genetics, Period Circadian Proteins physiology, Receptors, Adiponectin genetics, Receptors, Adiponectin physiology, Receptors, Leptin physiology, Circadian Rhythm physiology, Metabolic Syndrome physiopathology, Obesity physiopathology
- Abstract
Circadian rhythms (approximately 24h) are widely characterized at molecular level and their generation is acknowledged to originate from oscillations in expression of several clock genes and from regulation of their protein products. While general entrainment of organisms to environmental light-dark cycles is mainly achieved through the master clock of the suprachiasmatic nucleus in mammals, this molecular clockwork is functional in several organs and tissues. Some studies have suggested that disruption of the circadian system (chronodisruption (CD)) may be causal for manifestations of the metabolic syndrome. This review summarizes (1) how molecular clocks coordinate metabolism and their specific role in the adipocyte; (2) the genetic aspects of and scientific evidence for obesity as a chronobiological illness; and (3) CD and its causes and pathological consequences. Finally, ideas about use of chronobiology for the treatment of obesity are discussed., (Copyright © 2011 SEEN. Published by Elsevier Espana. All rights reserved.)
- Published
- 2012
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