1. [Application of proteomics to neurological diseases].
- Author
-
Brea D, Cristobo I, Sobrino T, Rodríguez-González R, Mosquera E, Moldes O, and Castillo J
- Subjects
- Alzheimer Disease genetics, Alzheimer Disease metabolism, Amyotrophic Lateral Sclerosis genetics, Amyotrophic Lateral Sclerosis metabolism, Cells, Cultured metabolism, Chromatography, Liquid methods, Electrophoresis, Gel, Two-Dimensional, Epilepsy genetics, Epilepsy metabolism, Gene Expression Profiling methods, Gene Expression Regulation, Humans, Huntington Disease genetics, Huntington Disease metabolism, Mass Spectrometry methods, Nerve Tissue Proteins analysis, Nerve Tissue Proteins biosynthesis, Nerve Tissue Proteins genetics, Nervous System Diseases diagnosis, Nervous System Diseases genetics, Proteins genetics, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Stroke genetics, Stroke metabolism, Subtraction Technique, Nervous System Diseases metabolism, Proteins analysis, Proteomics methods
- Abstract
Proteomic is a set of tools that allows the separation and identification of proteins expressed by a cell, tissue or organism. Two-dimensional electrophoresis is the central tool that allows qualitative and quantitative comparisons of protein patterns between samples. Differential analysis of protein expression patterns in different neurological diseases (stroke, Alzheimer, Parkinson, amyotrophic lateral sclerosis, Hungtington, epilepsy) allows the identification of diagnostic and/or prognostic biomarkers. Subsequently, validation of these markers may help to identify new diagnostic and therapeutic targets.
- Published
- 2007