1. Dual prophylaxis with teicoplanin and cefazolin in the prevention of prosthetic joint infection.
- Author
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Barbero-Allende JM, García-Sánchez M, Montero-Ruiz E, Vallés-Purroy A, Plasencia-Arriba MÁ, and Sanz-Moreno J
- Subjects
- Aged, Arthritis, Infectious epidemiology, Arthritis, Infectious etiology, Arthritis, Infectious microbiology, Arthroplasty, Bacterial Infections epidemiology, Bacterial Infections microbiology, Cefazolin administration & dosage, Cefazolin adverse effects, Cephalosporin Resistance, Drug Resistance, Multiple, Bacterial, Drug Substitution, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Prosthesis-Related Infections epidemiology, Prosthesis-Related Infections microbiology, Surgical Wound Infection epidemiology, Surgical Wound Infection microbiology, Teicoplanin administration & dosage, Teicoplanin adverse effects, Antibiotic Prophylaxis, Arthritis, Infectious prevention & control, Bacterial Infections prevention & control, Cefazolin therapeutic use, Prosthesis-Related Infections prevention & control, Surgical Wound Infection prevention & control, Teicoplanin therapeutic use
- Abstract
Introduction: There is a growing increase in prosthetic joint infection (PJI) incidence due to cephalosporin-resistant bacteria, used in surgical prophylaxis. The replacement of these with glycopeptides has not been shown to improve the results, but they have been shown to improve with their combination., Methods: Comparative study of combination of teicoplanin and cefazolin before arthroplasty surgery against cefazolin alone from a previous control group., Results: During the control period, there were 16 PJIs from 585 surgeries, while in the intervention group there were 6 from 579 (incidence 2.7% vs. 1.03%, RR 0.4, P=.04). In control group, 11 of the infections were caused by Gram-positive bacteria versus 4 in the intervention group (1.8% vs. 0.7%, P=.08)., Conclusions: The addition of teicoplanin to cefazolin in the prophylaxis of arthroplasty surgery was associated with a reduction in the incidence of PJI, thanks to a decrease in infections caused by Gram-positive bacteria., (Copyright © 2019 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.)
- Published
- 2019
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