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Internal motivation to change is one of the important factors of treatment. We come up from the concept of selfdetermination theory (Deci and Ryan, 2000), which describes the motivation for a change in perception and behavior assumes intrinsic behavior activity. This research combines positive experience in application of motivational interview (MI) during exercise activity (PA). Objectives: The objectives of this research target three areas. First of all the research tries to find out whether MI during SPAP has an influence on expressed physical fitness represented by endurance, muscle strength and physical dexterity. Second, the research focuses on whether or not, or to what extent MI during SPAP can affect the psychomotor tempo of performance of a visual-motor activity. And third, whether or not, or to what extent MI during SPAP can reduce anxiety and depression. Materials and methods: The examined group included 141 hospitalized patients. These patients were diagnosed with various mental disorders such as schizophrenia, mood disorders and anxiety and behavioral disorders caused by psychoactive substance usage. The experimental group and the control group received physical activity interventions 2 times a week for a period of 6 weeks. In comparison with a control group, the experimental group received a motivational interviewing during physical activity. The research used 3 ten-point scales to measure the level of the expressed physical fitness, namely endurance, muscle strength an dexterity in exercise and the Path Test measuring the psychomotor tempo. Levels of anxiety and depression were obtained from the HADS questionnaire, which has two subscales. The HADS-A subdatal detects the level of anxiety, and the HADS-D subdatal detects the level of depression. The research results were evaluated against a ten-point scale measuring the level of expressed physical fitness (endurance, muscle strength and physical dexterity), and by the Trail Making Test measuring the psychomotor tempo. Values showing the level of anxiety and depression were obtained with the help of the HADS questionnaire with its two sub-scales: sub-scale HADS-A for anxiety and sub-scale HADS-D for depression. Outcomes: The collected data confirmed a significant effect of MI conduct in the course of a SPAP on the expressed overall physical fitness as well as on its individual measured components, p = 0.000, and the psychomotor tempo, p = 0.000. The data did not confirm any significant effect of MI conducted in the course of a SPAP on the expressed level of anxiety for the whole group of hospitalised patients, p = 0.603, and showed no significant effect of MI in the course of a SPAP on the expressed level of depression either, p = 0.450. The patients undergoing the SPAP in the context of their hospital therapy only showed a statistically significant improvement of their psychomotor tempo, p = 0.000. Conclusion: The resulting can be stated that MI during SPAP may be used as a supplementary method of influencing depression and anxiety in patients in general. In the case of depressive patients suffering from anxiety and behavior disorders caused by psychoactive substance usage and in the case of anxiety in patients suffering from pathological anxiety, MI during SPAP may even be used as a significant therapeutic method. [ABSTRACT FROM AUTHOR]