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The beginnings of clinical pharmacy at the University clinic Golnik date back to the year 2004. Herein the developments that led to the recognition of clinical pharmacists as a member of the healthcare team and their integration in routine patient care are described. Special emphasis is put on the role of research activities throughout the implementation of clinical pharmacy services. Clinical pharmacy services should be well-defined and regularly provided, focusing on patients at high risk for serious adverse drug events and tackling problems where clinical pharmacists' expertise is most needed. Nevertheless, clinical pharmacy services should be well integrated into routine clinical practice and accepted by other healthcare professionals in order to achieve their final goal: optimising patient care. Začetki klinične farmacije na Kliniki Golnik segajo v leto 2004. V prispevku opisujemo pot klinične farmacije od takrat do danes, ko je klinični farmacevt prepoznan kot pomemben član zdravstvenega tima in vključen v vsakodnevno obravnavo bolnikov na Kliniki Golnik. Poseben poudarek namenjamo pomenu raziskovanja pred, ob in po uvajanju novih storitev klinične farmacije. Izpostavljamo tudi nujnost jasne definicije nalog kliničnih farmacevtov in njihovega rednega izvajanja, z osredotočanjem na bolnike, kjer je tveganje za neželene dogodke zdravljenja z zdravili največje in kjer lahko z našo ekspertizo najbolj pripomoremo k preprečevanju zapletov v zdravljenju z zdravili. In, nenazadnje, spominjamo, da klinični farmacevti delujemo v multiprofesionalnem timu, zato samo izvajanje storitev klinične farmacije ne more doseči svojega osnovnega namena optimizacije zdravljenja z zdravili, če naše delovanje ni dobro integrirano in sprejeto s strani drugih zdravstvenih delavcev.

The most important parameters when appropriate control of the pain is desired are description of the pain, the timing and location, the choice of an appropriate analgesic and consideration of side effects. Nonopioid analgesics are comparable due to efficacy, so their choice is mostly based on a drug safety profile. On the other hand, opioid analgesic differ in terms of efficacy and have more or less the same safety profile.

Predmet razprave diplomskega dela je tetivni štirikotnik ABCD z očrtano krožnico k ter presečiščem diagonal E. V diplomskem delu so opisani in natančno dokazani nekateri novejši rezultati o tetivnih štirikotnikih. Poseben poudarek je namenjen rezultatom, ki jih je mogoče dokazati s pomočjo koncepta polarnosti, rezultatom o značilnih točkah trikotnikov ABC, ABD, ACD in BCD, rezultatom o simetralah kotov ter rezultatom o značilnih točkah trikotnikov ABE, BCE, CDE in ADE. The main topic of this diploma thesis is the cyclic quadrilateral ABCD with the circumcircle k and the intersection of diagonals E. The diploma thesis includes a description and a concise proof of some of the newest findings concerning cyclic quadrilaterals. Particular emphasis has been placed upon findings which can be proven with the help of the polarity concept, findings concerning the distinct points of the triangles ABC, ABD, ACD, and BCD, findings about the angle bisectors, and findings concerning the distinct points of the triangles ABE, BCE, CDE, and ADE.