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Za določitev odziva na vzvojno obremenjevanje je treba uporabiti namensko vzvojno preizkuševališče. Lahko pa na natezno-tlačnem preizkuševališču postavimo vmesnik, ki poleg pretvorbe natezno-tlačnega v vzvojno obremenjevanje omogoča tudi merjenje vzvojnega napetostno-deformacijskega odziva. V okviru magistrskega dela smo konstruirali vmesnik za izvajanje vzvojnih obremenitev na natezno-tlačnem preizkuševališču. Postavili smo analitični in numerični model in z njima ovrednotili vmesnik. Nato smo na preizkuševališču izvedli porušitvene teste na različnih nivojih za izris Coffin-Mansonove krivulje ter inkrementalni test za določitev stabilizirane ciklične krivulje. Rezultate analitičnega in numeričnega modela smo primerjali z rezultati, ki smo jih določili eksperimentalno. Preizkuševališče smo ovrednotili na način, ki omogoča zamenjavo materiala preizkušancev, ponovitev postopka kalibracije in izvedbo večjega števila eksperimentalnih testov. Estimating the response to torsional loading requires the use of a dedicated torsional test rig. Alternatively, an adapter that converts an usual tension-compression loading into torsional loading can be applied. The adapter also enables the measurement of the torsional stress-strain response. In this master thesis, an adapter was designed for the implementation of torsional loads on a tensile-compressive test rig. An analytical and numerical model were built to ensure the adapter’s evaluation. Then, fatiguelife experiments were conducted at various levels to plot the Coffin-Manson curve and incremental test to determine the stabilized cyclical curve. The results of the analytical and numerical model were carried out with the results determined experimentally. The test rig was evaluated in a way that allows changing the material of the specimen, repeating the calibration process and performing a larger number of experimental tests.

V diplomskem delu je podrobno predstavljena kultura veganstva in njeno stanje v Sloveniji. Za razumevanje različnih prehranjevalnih modelov je potrebno razumeti celotno kulturo prehranjevanja, ki je kompleksen proces različnih družbenih in kulturnih dejavnikov, zato v ta namen najprej v delu obravnavam zgodovino prehranjevanja. Raziskujem načine prehranjevanja skozi različna zgodovinska obdobja, kasneje pa se podrobneje posvetim vegetarijanstvu in nato veganstvu. Diplomsko delo poleg uvodnega teoretičnega dela sestoji tudi iz empiričnega, kjer so predstavljeni rezultati intervjujev, opravljeni z desetimi vegani. V opornem empiričnemu delu obravnavam vzroke in posledice veganstva, informiranost družbe, vsesplošno povezovanje veganske prehrane z zdravo prehrano, ponudbo na trgu in prihodnost veganstva. S pomočjo teoretičnega in opornega empiričnega dela v nalogi ugotavljam družbene in kulturne vzroke ter posledice kulture veganstva za širšo kulturo prehranjevanja. This thesis presents a detailed overview of the vegan culture and its situation in Slovenia. In order to understand the different dietary models, it is necessary to understand the whole culture of eating, which is a complex process of different social and cultural factors, and for this purpose I first discuss the history of eating. I explore dietary patterns through different historical periods, and later I look in more detail at vegetarianism and then veganism. In addition to an introductory theoretical part, the thesis also consists of an empirical part, where the results of interviews conducted with ten vegans are presented. In the supporting empirical part I discuss the causes and consequences of veganism, the information society, the general association of vegan diets with healthy eating, the market offer and the future of veganism. Through theoretical and supporting empirical work, the thesis identifies the social and cultural causes and implications of vegan culture for the wider food culture.

Radioterapija je eden treh stebrov zdravljenja rakov glave in vratu. Začetki segajo v konec 19. stoletja, vsa dosedanja spoznanja pa danes omogočajo uspešno zdravljenje ob sprejemljivi toksičnosti. S sodobnimi obsevalnimi tehnikami lahko pri sluzničnih karcinomih glave in vratu v zgodnjih stadijih dosežemo popolno lokalno kontrolo bolezni, medtem ko je pri lokoregionalni bolezni obsevanje pogosto edino zdravljenje, ki prinaša možnost ozdravitve. V prihodnosti lahko ob tehničnem napredku, kot sta uporaba adaptivnega pristopa k obsevanju in uporaba visokoenergijskih delcev z ugodnejšimi fizikalnimi lastnostmi, ter predvsem ob napredku v razumevanju mehanizmov občutljivosti na obsevanje pričakujemo nadaljnje pomembne korake k izboljšanju uspehov radioterapije ob nespremenjeni ali celo zmanjšani toksičnosti.

Oligometastatska bolezen (OMB) predstavlja vmesno stanje med lokalno napredovalo boleznijo in obsežnejšo metastatsko boleznijo. Zaenkrat ne poznamo specifičnih biomarkerjev, ki bi nam pomagali opredeliti bolnike z majhnim bremenom bolezni, zato diagnoza OMB temelji na slikovni diagnostiki. V zadnjih letih narašča zanimanje za optimizacijo zdravljenja OMB predvsem zaradi obetavnih rezultatov dodatka lokalnega k obstoječemu sistemskemu zdravljenju. S takšnim načinom zdravljenja se je prvič pokazala možnost doseganja dolgotrajnih zazdravitev ali redko celo ozdravitev teh bolnikov. Razlikovanje posameznih vrst OMB in njihovo enotno poimenovanje je pomembno zlasti v kliničnih raziskavah, saj nam omogoča medsebojno primerjavo rezultatov različnih raziskav. Oligometastatic disease (OMD) is a stage between locally advanced disease and polymetastatic disease, a group of diseases that are used interchangeably based on treatment history, ongoing treatment status, and imaging findings. The diagnosis of OMD is based on imaging because, as of yet, we are not aware of any specific biomarkers that would enable us to recognize patients with a low disease burden. In recent years, there has been an increasing interest in optimizing the treatment of OMD, owing mostly to the promising outcomes of combining local and systemic treatment. For the first time, the prospect of achieving long-term cures or possibly curing these individuals was established using this form of treatment. The standard name of OMD subgroups allows for the comparison of diverse circumstances in everyday clinical work, as well as the classification for clinical study comparability.

Uvod: Nosečnost je eno pomembnejših obdobij v življenju vsake ženske in velja za stresno in zahtevno obdobje. Nosečnice že tako doživljajo povišano anksioznost zaradi samega dejstva, da so noseče in spremljajočih sprememb, v času epidemije COVID-19 pa so se pridružile še dodatne okoliščine – potrebe po prilagajanju omejitvam. Stres je velikokrat odgovoren za škodljiv izid pri materi in novorojenčku, vključno z nizko porodno težo, prezgodnjim porodom, preeklampsijo, gestacijskim diabetesom in nenačrtovanim carskim rezom. Namen: Ugotoviti želimo, kakšne ravni stresa, povezanega z epidemijo COVID-19, doživljajo nosečnice v Sloveniji in na katerem področju doživljajo višje ravni stresa. Pri tem nas bo zanimalo tudi, če so naši rezultati primerljivi z rezultati nekaterih drugih držav. Metode dela: Uporabljena je bila deskriptivna in kavzalno neeksperimentalna metoda empiričnega raziskovanja. Raziskovalni pristop je temeljil na kvantitativni raziskavi, za raziskovalno orodje je bil uporabljen validiran vprašalnik, imenovan PREPS lestvica. Rezultati: V raziskavi so sodelovale 1104 nosečnice. Ugotovili smo, da se je v času epidemije COVID-19 več kot tretjina sodelujočih soočalo z visokimi ravnmi stresa. S pridobljenimi podatki smo ugotovili tudi, da so višje ravni stresa doživljale tiste, ki so bile v času epidemije COVID-19 noseče prvič, so imele rizično nosečnost, so izgubile vir dohodka ter so bile v času reševanja ankete v 2. ali 3. trimesečju. Prav tako smo ugotovili, da so nosečnice v Sloveniji najvišje ravni stresa doživljale zaradi skrbi glede okužbe. Razprava in zaključek: Vpliv epidemije na počutje nosečnic je zaskrbljujoč. Kot je razvidno iz rezultatov, je s strani anketirank v našem vzorcu prisotno stanje doživljanja vse od blagega do hudega stresa. Velik del stresa, ki so ga doživljale nosečnice v času epidemije COVID-19, je posledica skrbi glede okužbe in pomanjkanja pripravljenosti na porod (kot posledica omejenih zdravstvenih storitev). Pomembno se je zavedati, da stres med nosečnostjo ne vpliva le na enega človeka, ampak vpliva tudi na plod in njegov razvoj. Ženskam bi bilo smiselno pomagati pri soočanju in lajšanju stresa, npr. spletne svetovalnice za podporo in podajanje koristnih informacij. Prav tako bi bilo smiselno izvajati preventivno preverjanje doživljanja stresa s pomočjo PREPS lestvice ali kakšnega drugega v ta namen razvitega presejalnega instrumenta. Introduction: Pregnancy is one of the most important periods in the life of every woman and is considered a stressful and demanding period. Pregnant women are already experiencing increased anxiety due to the very fact that they are pregnant and the accompanying changes, and during the COVID-19 epidemic, additional circumstances joined in - the need to adjust to the restrictions. Stress is often responsible for the detrimental outcome in mother and newborn, including low birth weight, preterm birth, preeclampsia, gestational diabetes and unplanned cesarean section. Purpose: We want to determine what levels of stress related to the COVID-19 epidemic are experienced by pregnant women in Slovenia and in which area they experience higher levels of stress. we will also be interested to see if our results are comparable to those of some other countries. Methods of work: A descriptive and causally non-experimental method of empirical research was used. The research approach was based on quantitative research, and a validated questionnaire called the PREPS scale was used for the research tool. Results: 1104 pregnant women participated in the study. We found that during the COVID-19 epidemic, more than a third of the participants faced high levels of stress. The data also showed that those who were pregnant for the first time during the COVID-19 epidemic, had a high-risk pregnancy, lost their income and were in the 2nd or 3rd trimester at the time of the survey experienced higher levels of stress. We found that pregnant women in Slovenia experienced the highest levels of stress due to concerns about infection. Discussion and conclusion: The impact of the epidemic on the well-being of pregnant women is worrying. As can be seen from the results, the respondents experience a state of experience ranging from mild to severe stress in our sample. Much of the stress experienced by pregnant women during the COVID-19 epidemic is due to infection concerns and lack of readiness for childbirth (as a result of limited health services). It is important to be aware that stress during pregnancy not only affects one person but also affects the fetus and its development. It would make sense to help women cope with and relieve stress, e.g. online counseling for support and useful information. It would also make sense to carry out preventive checks on the experience of stress with the help of the PREPS scale or some other screening instrument developed for this purpose.

Standardni model ima dve naključni globalni simetriji $U(1)_{B}$ barionsko in $U(1)_{e} times U(1)_{mu} times U(1)_{tau}$ in leptonsko, ki velja za vsako družino posebej. Barionsko število je definirano tako, da imajo barioni (n,p) barionsko število $B = 1$, antibarioni $(overline{n}, overline{p})$ barionsko število $B = -1$. Leptonsko število pa je definirano za leptone $L_{e,mu,tau} = 1$, za antileptone $overline{L}_{e,mu,tau} = -1$. Obe simetriji sta ohranjeni znotraj standardnega modela in zato preprečujeta oscilacije barionov in razpad protona. Teorija velikega poenotenja ($GUT$) razširi standardni model z uvedbno novih hipotetičnih delcev leptokvarkev (LQ). Ti pa so novi prenosniki interakcije, ki omogočijo kršitev barionskega števila za $Delta B = 1$ eno enoto in s tem možni razpad protona. Pri kršitvi barionskega števila za $Delta B = 2$ pa imamo oscilacije med barioni $n - overline{n}$. Kršitev leptonskega števila za $Delta L = 2$ dve enoti, ki se eksperimentalno išče pri beta razpadu, bi določila naravo nevtrina, ki bi bil Majorana nevtrino. V tem magistrskem delu obravnavamo oscilacije med barioni s poudarkom na nevtronu. Opišemo razpad nevtrona v Majorana fermion $n rightarrow chi$ na drevesnem nivoju in nato še na nivoju ene zanke. Na drevesnem nivoju je prenosnik interakcije leptokvarek $S_{1}$, na nivoju ene zanke pa $overline{S}_{1}$. Eksperimentalno potrjena oscilacija med nevtronom in antinevtronom bi imela velik pomen pri razlagi neravnovesja med snovjo in antisnovjo v našem vesolju. Veliko eksperimentov si prizadeva izmeriti mešalni čas med nevtronom in antinevtronom, s čimer bi potrdili oscilacijo med nevtronom in antinevtronom. Standard Model has two accidental global symmetries $U(1)_{B}$ baryon number and $U(1)_{e} times U(1)_{mu} times U(1)_{tau}$ lepton number, which holds for each family. We define baryon number $B = 1$ for baryons $(n,p)$ and $B = -1$ for antibaryons $(overline{n}, overline{p})$. For lepton number we define $L_{e,mu,tau} = 1$ for leptons and $overline{L}_{e,mu,tau} = -1$ for antileptons. Both symmetries are conserved in Standard Model for which oscillations between baryons and proton decay are forbidden in Standard Model. Grand Unified Theory (GUT) introduces new hypothetical particles Leptoquarks (LQ) for which we get theory Beyond Standard Model (BSM). LQ are new interaction mediators that allow us to violate the baryon number for one or two units. Violation for one unit gives us proton decay and violation for two units gives us neutron antineutron oscillations. There is also an experimental search for double beta dacay, which would violate a lepton number for $Delta L = 2$ two units and give us proof that the neutrino is a Majorana fermion. In this thesis we consider oscillations between baryons with emphasis on the neutron. We calculate decay amplitude for the transition of a neutron into Majorana fermion $n rightarrow chi$ on tree-level and one-loop level. At the tree level, LQ $S_{1}$ is interaction mediator, and $overline{S}_{1}$ is the interaction mediator for one loop. Experimental observations of the neutron antineutron oscillation would greatly impact the asymmetry between matter and antimatter. Many experiments are trying to measure oscillation time between neutron and antineutron, which would prove the existence of neutron antineutron oscillation.

Alzheimerjeva bolezen (AB) je progresivna nevrodegenerativna bolezen, ki pretežno pesti starejši del populacije. Najbolj znana hipoteza, ki opisuje nastanek bolezni je amiloidogena hipoteza, ki pravi, da so zunajcelični plaki, ki nastanejo zaradi prekomernega odlaganja peptida amiloid beta (Aβ), glavni razlog za nastanek AB. Aβ je peptid, ki se v plakih nahaja pretežno v dolžinah 1–40 in 1–42, pa tudi v dolžini 25–35. Za Aβ 1–40 in 1–42 je bila pokazana specifična vezava s profilinom 1, ki je življenjsko pomemben protein. Sodeluje pri procesu polimerizacije aktina, v nevronih pa je pomemben regulator morfologije in sinaptične plastičnosti. V okviru magistrske naloge smo želeli preveriti citotoksični vpliv peptida Aβ različnih dolžin (1–40, 1–42, 25–35) in oblik (monomeri in fibrile), ter določiti subletalno koncentracijo za nevroblastomsko celično linijo SH-SY5Y v treh časovnih intervalih (24, 48 in 72 ur). Viabilnost celic smo določali s kolorimetrično metodo MTS. Ugotovili smo, da je peptid Aβ 1–42 tako v obliki monomerov kot fibril za celice najbolj toksičen. Monomeri že pri koncentraciji 1 µM po 48 urah povzročijo statistično značilno zmanjšanje viabilnosti celic, fibrile pa pri 2 µM koncentraciji. Prav tako posnetki celic v prisotnosti peptida 1–42 kažejo največ morfoloških sprememb. Za vse tri peptide smo pokazali, da je preživetje celic koncentracijsko in časovno odvisno, kjer se z večanjem koncentracije in daljšo časovno izpostavljenostjo peptidu manjša viabilnost celic. S peptidi v določeni subletalni koncentraciji smo nadalje preverili njihov vpliv na vsebnost proflina 1 v celicah. Celice smo za 24 ur izpostavili dvema različnima koncentracijama obeh oblik posameznega peptida in v celičnih lizatih z metodama SDS-PAGE ter prenos western določili vsebnost profilina 1 in aktina. Vsebnost profilina 1 v celicah je pri vseh peptidih v obliki monomerov večja kot pri kontrolnih vzorcih. Prav tako tudi pri fibrilah, razen pri peptidu 1–42 100 nM koncentracije, medtem ko fibrile peptida 25–35 povzročijo zmanjšano vsebnost profilina 1 v celičnih lizatih. Aβ bi lahko imel vpliv na procese transkripcije in translacije profilina 1, kar bo predmet nadaljnjih raziskav. Alzheimer's disease is a progressive neurodegenerative disease that predominantly affects the elder population. Leading hypothesis describing the cause of the disease is the amyloid hypothesis, according to which the main cause of Alzheimer’s disease are the extracellular plaques formed in excessive deposition of the amyloid beta peptide (Aβ). Aβ is a peptid, predominantly found in plaques with lengths 1–40 and 1–42, but also in length 25–35. Aβ 1–40 and 1–42 have proved to bind specifically to profilin 1, a vital protein. Profilin 1 regulates actin polymerisation and is crucial for morphology and synaptic plasticity regulation in neurons. The goal of our master’s thesis was to verify the cytotoxic effect of Aβ peptide of different lengths (1–40, 1–42, 25–35) and forms (monomers and fibrils), and to determine the sublethal concentration for the SH-SY5Y neuroblastoma cell line at three time intervals (24, 48 and 72 hours). Cell viability was determined by the MTS colorimetric method. Results showed that Aβ 1–42 peptide is most toxic to cells in both monomeric and fibril forms. Monomers at a concentration as low as 1 µM caused a statistically significant decrease in cell viability after 48 hours, whereas fibrils reacted in the same manner at 2 µM. Similarly, cell microscopy showed the biggest morphological changes in the presence of peptide 1–42. For all three peptides the results have proved that cell survival is concentration- and time-dependent, where cell viability decreases with increasing concentration and longer exposure to the peptide. At given sublethal concentration further analyses were performed to observe the effect on profilin 1 content in cells. Cells were exposed to two different concentrations of both forms of each peptide for 24 hours and profilin 1 and actin content in cell lysates were determined by SDS-PAGE and western blot method. The cellular profilin 1 content was higher for all peptides in monomeric form compared to control samples. Through observation of fibrils, a similar conclusion was formed, with the exception of peptide 1–42 at 100 nM concentration, while fibrils of peptide 25–35 showed a reduced profilin 1 content in cell lysates. Therefore, Aβ could have an effect on the transcription and translation processes of profilin 1, which poses a possibility for further investigation.

Učitelji se dnevno srečujejo z izzivom, kako otrokom v šoli ponuditi kvalitetne didaktične pripomočke. Te večinoma izdelujejo sami, saj jih na trgu ni veliko. V magistrski nalogi je predstavljeno načrtovanje, oblikovanje in izdelava didaktične igre za otroke, ki obiskujejo šolo z nižjim izobrazbenim standardom. Izdelana igra je uporabna za pomoč pri učenju in utrjevanju prepoznavanja glasov pri pouku slovenščine. Prav tako lahko z njo starši doma utrjujejo in dopolnjujejo otrokovo znanje prepoznavanja glasov. V teoretičnem delu je opredeljena ciljna skupina, ki jo predstavljajo otroci z lažjo motnjo v duševnem razvoju in njihovo govorno izražanje. Obravnavani so glavni vidiki družabnih iger, naredili smo pregled ilustracij v igrah, ki imajo terapevtski namen. Dotaknemo se tudi kapljičnega tiska in materialov, iz katerih so igre izdelane. Nalogo se zaključi z raziskavo trga. V eksperimentalnem delu je opisano načrtovanje didaktične igre, potek ilustriranja igre, priprava embalaže in elementov igre za tisk, pregled materialov, ki so bili uporabljeni za izdelavo prototipa igre, in priprava preglednice, ki je bila v pomoč pri testiranju igre v šoli. Rezultat zaključne naloge je didaktična igra vidim, slišim, povem, ki je bila uspešno testirana v šoli z otroki s posebnimi potrebami. Teachers face the daily challenge of providing quality educational (didactic) tools to children in school. They usually make them themselves, as there are not many on the market. The master's thesis is dealt with the planning, design and production of a didactic game for children with a lower educational standard attending school. The game we developed helps children learn and consolidate the recognition of voices in the Slovene language classes. It can also be used by parents at home to consolidate and develop their child's knowledge of voice recognition. The theoretical part is focused on the definition of the target group - children with mild intellectual disability - and their oral communication. The main aspects of board games are discussed and an overview of illustrations in games with therapeutic purpose is given. Inkjet printing and the materials used to make the games are aslo discussed. The paper with a market research was concluded. In the experimental part is described our planning of the didactic game, the process of illustrating the game, preparing the packaging and elements of the game for printing. The materials used to make a prototype of the game are presented, and a table to help in testing the game at school is prepared. The result of the work is a didactic game called "I see, I hear, I say", which was successfully tested in school on children with special needs.

The overall aim of this focus issue of the CEPS Journal has been to dis-cuss the various issues that any education reform brings along. Alongside verti-cal and thematically oriented criteria, a particular focus has been made on the issues addressed by the authors of these contributions that reflect the broader social and political circumstances that impact educational change. Given the tumultuous changes brought by the Covid-19 pandemic as well as a panoply of issues as diverse as populism, fake news, hate speech, the shrinking civic space, and similar, there are many topics to be explored further, not only in how education can respond to them but also how education shapes the future of our societies.

Članek poskuša konceptualizirati odnos med individualnim (stro-kovnim) in strukturnim v obdobju razmeroma korenitih sprememb v družbi. Izzivalna in razkrivajoča dialektika takih odnosov je analizirana s kombinacijo avtoetnografskih razmislekov, ob naslonitvi na arhivske dokumente, ki prikazujejo spremembe v delovanju strokovnega sveta v državi, ki je doživela tri temeljne miroljubne prehode in se tudi spopadla z njimi: prehod iz samoupravnega socialističnega gospodarstva v tržno gospodarstvo, prehod iz enopartijskega socialističnega sistema v repre-zentativno liberalno demokracijo in prehod iz republike, ki je bila del zvezne države, v neodvisno državo. Strokovni svet Socialistične republi-ke Slovenije (takrat še del Socialistične republike Jugoslavije), pozneje preimenovan v Strokovni svet Republike Slovenije (takrat že liberalna demokracija s tržnim gospodarstvom in z neodvisno državo), lahko slu-ži kot primer produktivnega prepletanja individualnega (strokovnega) in strukturnega pri oblikovanju in izvajanju preobrazbe izobraževalnega sistema. Kontekstualizirani prikaz in ocena premikov, ki so skupaj pri-pomogli k nastanku neodvisne države in njenega oblikovanja izobraže-valnega sistema, opisuje zapletenost in pomen refleksivnega upravljanja v času tranzicije, ki sama po sebi v ospredje postavlja vrsto pomembnih vprašanj ter vabi in podpira spremembe v izobraževalnem sistemu. Ta-kšne priložnosti država in njeni edukatorji ne bi smeli zamuditi. This article attempts to conceptualise the relationship between the indi-vidual (professional) and the structural in a period of relatively radical changes in society. The challenging and revealing dialectic of such rela-tions is analysed through the combination of auto-ethnographic reflec-tions and archival documents showing the changes in the functioning of a council of experts in a country that experienced and coped with three fundamentally peaceful transitions: the transition from a self-managed socialist economy to a market economy, the transition from a one-party socialist system to a representative liberal democracy, and from a re-public that was part of a federal state to an independent state. The Ex-pert Council of the Socialist Republic of Slovenia (then still part of the Socialist Republic of Yugoslavia), later renamed the Expert Council of the Republic of Slovenia (at that time a liberal democracy with a mar-ket economy and an independent state), can serve as an example of the productive intertwining of individual (expert) and the structural in the formulation and the implementation of the functional transformation of the educational system. The contextualised account and assessment of the shifts that together helped bring about the independent state and its education system formation outlines the complexity and importance of reflexive governance in the times of transition, which, in itself, brings to the fore a number of relevant issues and invites and supports change in the educational system. Such an opportunity should not be missed by the country and its educators.

Izhodišča: Imunoterapija z zaviralcem imunskih kontrolnih točk nivolumabom, zaviralnim protitelesom proti proteinu programirane celične smrti 1 (PD-1), je za bolnike z neozdravljivo ponovitvijo bolezni ali sistemskimi zasevki ploščatoceličnega karcinoma glave in vratu (P/Z PKGV), pri katerih je bolezen neobčutljiva na preparate platine, pomembna nova možnost zdravljenja. V primerjavi s citostatiki pomembno podaljša njihovo preživetje. Metode: Opravljena je bila retrospektivna analiza zdravljenja z nivolumabom pri slovenskih bolnikih s P/Z PKGV, ki so prejeli prvi odmerek nivolumaba do marca 2020. Zbiranje podatkov je bilo končano septembra 2020. Uporabljene so bile opisne statistične metode in test log-rank. Rezultati: V raziskavo je bilo vključenih 27 bolnikov. Srednji čas sledenja od prve aplikacije nivolumaba do konca opazovanja je bil 7,4 meseca, relativno šestmesečno celokupno preživetje pa 59- odstotno (95-odstotni interval zaupanja pri 41–78 %). Odgovor na zdravljenje je bil pri 85 % bolnikov ocenjen s kliničnim pregledom in rentgenskim slikanjem prsnega koša, pri čemer je bil pri 41 % kot najboljši odgovor ugotovljen delen odgovor na zdravljenje. Imunsko pogojeni neželeni dogodki so se pojavili pri 30 % bolnikov, pri čemer so bili vsi gradusa ≤ 2. En bolnik je bil sočasno z nivolumabom tudi obsevan. Zaključek: Glede na zbrane podatke se je tudi v slovenski populaciji bolnikov s P/Z PKGV zdravljenje z nivolumabom izkazalo za varno. Zaradi kratkega časa sledenja ugotovljene učinkovitosti ni mogoče primerjati z rezultati tujih raziskav. S pričakovano odobritvijo pembrolizumaba bodo zaviralci imunskih kontrolnih točk tudi v Sloveniji dobili mesto v prvem redu zdravljenja P/Z PKGV. Background: Immunotherapy with the immune checkpoint inhibitor nivolumab – an inhibitory antibody against programmed death receptor-1 (anti-PD-1) – represents an important new treatment option for patients with an incurable recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) that is unresponsive to platinum-based chemotherapy. It significantly prolongs survival compared to standard chemotherapy. Methods: A retrospective analysis of treatment with nivolumab in patients with R/M HNSCC in Slovenia who received their first dose of nivolumab by March 2020 was performed. Data collection was completed in September 2020. Descriptive statistics and log rank tests were used. Results: Twenty-seven patients entered the study. The median time of follow-up from the first nivolumab application onward was 7.4 months, and the relative six-month overall survival rate was 59% (95% confidence interval 41–78%). In 85% of patients, the response to treatment was evaluated using clinical examination and chest x-ray only. In 41% of patients the partial response to treatment was declared as the best response achieved. Thirty per cent of patients experienced immune-related adverse events, of which all were grade ≤2. In one patient radiotherapy was delivered concurrently with nivolumab. Conclusion: According to the presented results, treatment with nivolumab has also been shown to be safe in Slovenian patients with R/M HNSCC. Due to the short follow-up time, the observed efficacy cannot be compared with the results of foreign studies. With the expected approval of pembrolizumab, immune checkpoint inhibitors will also be given a place in the first line treatment of R/M HNSCC in Slovenia.

Priporočila za obravnavo rakov glave in vratu (RGV) v Sloveniji sledijo priporočilom in usmeritvam, povzetim v publikaciji neprofitne mreže 30 vodilnih severnoameriških inštitucij za obravnavo raka, National Comprehensive Cancer Network, in hkrati upoštevajo obstoječe zmožnosti slovenskega zdravstvenega sistema. Smernice predstavljajo poenoteno mnenje vseh štirih najpomembnejših deležnikov na področju obravnave rakov glave in vratu v državi: Klinike za otorinolaringologijo in cervikofacialno kirurgijo, Kliničnega oddelka za maksilofacialno in oralno kirurgijo ter Stomatološke klinike UKC Ljubljana, Klinike za otorinolaringologijo, cervikalno in maksilofacialno kirurgijo UKC Maribor ter Onkološkega inštituta Ljubljana., Onkologija : strokovno-znanstveni časopis za zdravnike, Vol 25 No 1 (2021)

V diplomskem delu je predstavljeno delovanje lokalnih in globalnih navigacijskih sredstev v letalstvu. Popisan je matematični model, ki globalni navigaciji omogoča določanje položja na Zemlji na osnovi kodnih ali faznih opazovanj. Predstavljen je lokalni navigacijski sistem, ki z podporo RTK GPS-a omogoča pristanek helikopterjev v zmanjšani vidljivosti. V nalogi je opisano in matematično podkrepljeno delovanje lokalnega navigacijskega sredstva. Za omenjen instrumentalni pristajalni sistem so opisani tudi postopki za uporabo sistema. This diploma thesis presents local and global navigation systems in relation with aviation. A detailed mathematical model is described, which enables global navigation systems to determine the position on Earth, based on code or phase observations. We also use a local navigation system with the support of RTK GPS to enable instrumental landing for helicopters in reduced visibility. The paper also describes mathematical equations of the mentioned local navigation system. In the end we present use procedures for our instrument helicopter landing system.

V magistrskem delu smo se ukvarjali z ATP rešitvijo podjetja Trend Micro, DDI in DDA. Za izvedbo magistrskega dela smo podrobneje spoznali postopke uporabe DDI in DDA. Najprej smo opisali zmožnosti in funkcije DDI in DDA. Postavili smo ustrezni testni sistem in spremljali grožnje, ki se pojavljajo v komunikacijskih omrežjih, ter njihovo delovanje preučevali v peskovniku. Poleg tega smo primerjali vplive različnih vrst zlonamerne programske kode in analizirali postopke ukrepanj ob zaznanih varnostnih incidentih. V zadnjem delu naloge so predstavljeni predlogi za izboljšanje informacijske varnosti, ki smo jih definirali s pomočjo rezultatov obravnavanja groženj z DDI in DDA. The subject of this master thesis was Trend Micro ATP solution DDI and DDA. For the realisation of our work, we studied usage procedures of DDI and DDA in detail. First, we describe capabilities and functions of DDI and DDA. Then we analysed detected malware which appeared inside monitored communication network. We also compared different types of malware and studied their effect on different devices. At the end we present suggestions to improve information security in the monitored network, which we defined with results of malware analysis with DDI and DDA.

Do nedavnega sta bila poglavitna dejavnika tveganja za nastanek ploščatoceličnega karcinoma orofarinksa kajenje in prekomerno uživanje alkohola. Prognoza teh bolnikov je praviloma slaba, zaradi česar je zdravljenje intenzivno in multimodalno, kar edino nudi možnost ozdravitve, a hkrati povzroča resne neželene učinke. V zadnjih letih pa opažamo naraščanje incidence karcinoma orofarinksa, natančneje nebnic in jezične tonzile, pri bolnikih, ki so mlajši od tipičnih bolnikov s tem rakom in niso podvrženi škodljivim razvadam. Pri njih je povzročitelj karcinoma visokorizični podtip človeškega virusa papiloma (HPV). Ti bolniki v primerjavi s prvimi bolje odgovorijo na nekirurško zdravljenje in imajo pomembno daljše preživetje. Obenem to pomeni, da so ti bolniki agresivnega zdravljenja deležni v zgodnejšem življenjskem obdobju in morajo s posledicami tega živeti bistveno dlje. Zato se upravičeno poraja vprašanje, ali morda teh bolnikov s HPV povezanim rakom orofarinksa ne zdravimo pretirano agresivno. Predlaganih je bilo več načinov za zmanjšanje intenzivnosti zdravljenja, znani pa so tudi že prvi rezultati raziskav. Ti potrjujejo, da je način deintenzifikacije zdravljenja s kombinacijo sočasnega obsevanja in cetuximaba, ki je nadomestil cisplatin oz. karboplatin, neuspešen. Bolj obetavni so zgodnji rezultati kliničnih raziskav, ki vključujejo bodisi manj invazivno kirurgijo ali zmanjšanje odmerka radioterapije, z ali brez predhodne izbire bolnikov, primernih za deintenzifikacijo, z uvodno kemoterapijo. Mnoge raziskave so še v teku in morda bodo izsledki že kmalu spremenili paradigmo zdravljenja v tej skupini bolnikov. Do takrat pa ostaja zdravljenje karcinomov orofarinksa enako za vse bolnike, ne glede na etiologijo njihove bolezni., Onkologija : strokovno-znanstveni časopis za zdravnike, Vol 23 No 2 (2019)

Vsak pribor ima definirano neko mejo napake, znotraj tega intervala pa naj bi bil želen odmerjen volumen. V sklopu diplomske naloge smo preverjali merilno negotovost, pravilnost in natančnost posameznega volumetričnega pribora s statističnimi testi. V primerjavo smo vzeli polnilne pipete, birete, birete s kroglico, volumetrične steklenice in batne pipete. Pred eksperimentom smo pričakovali, da bo v splošnem najožje območje razširjene merilne negotovosti pri odmerjanju volumna z batno pipeto, največje pa bo pri odmerjanju volumna z volumetričnimi steklenicami. Ugotovili smo, da je območje razširjene merilne negotovosti močno odvisno od tega, kateri volumen smo odmerjali. V splošnem pa velja, da so za odmerjanje majhnih volumnov (do 1 mL) najbolj primerne batne pipete. Za odmerjanje večjih volumnov pa je bila najbolj primerna polnilna pipeta. Every volumetric instrument has its own error limit and within this area should be the desired volume. In diploma experiments we checked measurement uncertainty, trueness and precision of individual volumetric instrument with statistical tests. In comparison we took volumetric pipettes, burettes, burettes with bead stopcock, volumetric flasks and piston pipettes. Before the experiment we expected, the narrowest area of expanded measurement uncertainty with piston pipettes and the widest one with volumetric flasks. We found out that the area of expanded measurement uncertainty is strongly dependent on the measured volume. In general, we can say that for measurement of small volume (up to 1 mL) piston pipette is the most appropriate. For measurement of larger volume, the volumetric pipette is the most appropriate.

Beseda chanoyu (??) ali pa morda slovenska ustreznica čajni obred ali čajna ceremonija, je po navadi povezana z ustaljeno predstavo o harmonični kulturi pitja čaja, ki je ikonična za Japonsko. V njej je imel zelo pomembno vlogo velemojster Sen no Riky?? (???, 1522–21. april 1591), nekateri pa menijo, da je še danes najbolj znan mojster čaja na Japonskem. Zavedati se moramo, da je bila ta umetnost v zgodovini marsikaj več kot le druženje ob čaju. V času združevanja Japonske je njena priljubljenost narasla in postala je sredstvo, prek katerega so se ljudje družili ne samo znotraj svojih družbenih slojev, temveč tudi pripadniki različnih slojev. Riky??je?kot?mojster?čaja?v?času?združevanja?Japonske pomembno vplival na tedanje dogodke. V tem diplomskem delu bom razložila, kako je Riky? postal ne samo najvplivnejši mojster čaja na Japonskem, ampak tudi eden izmed najpomembnejših mož tistega časa. Njegov vpliv se je širil skupaj z vladavino njegovih dveh?pokroviteljev,?mogočnih?vojskovodij?Ode Nobunage?in?njegovega naslednika Toyotomija?Hideyoshija. Mojster je izpopolnil?nov slog chanoyuja,?ki?je bila tako razvedrilo kot?tudi??sredstvo za uresničevanje?določenih politično-vojaških?ambicij vojskovodij. Ta umetnost je v primerjavi z nasilnejšimi in bolj dolgotrajnimi pristopi omogočala združevanje Japonske in vzpostavljanje hierarhičnih odnosov in vlade na miroljubnejši način. When one hears the word chanoyu or perhaps the more common phrase tea ceremony, one associates it with the idea of a harmonious culture of drinking tea, which is thought to be iconic for Japan. The grandmaster Sen no Riky?? (???, 1522 – April 21, 1591) played a vital role in the history of chanoyu some would argue that he is the most well-known tea master in Japan even today. It is important to acknowledge that this gentle and refined art transcended a simple social gathering around tea. With its growing popularity in the time of the unification of Japan, it became a medium which enabled people to socialize not only inside the social classes they belonged to but also between the members of different social classes. As a tea master, Riky? had a great influence on the occurrences in the time of unification. In this thesis, I will strive to explain how Riky??became not only the most influential tea master in Japan, but also one of the most influential men of his time. His influence expanded with the rule of his patrons, the mighty warlords Oda?Nobunaga?and his heir Toyotomi Hideyoshi. The master perfected a new type of chanoyu, which represented entertainment as well as a means of achieving the warlords’ political and military ambitions. Consequently, it served as a more peaceful way of uniting the nation. Diplomacy was also achieved through this art, which meant that there was less need to resort to more violent methods of establishing proper hierarchy and rule.

Uvod: Časovno merjeni »ulezi se in vstani« test je bil zasnovan z namenom ugotavljanja funkcijske zmogljivosti zdravih odraslih. Namen: Namen diplomskega dela je bil ugotoviti ponovljivost in zanesljivost »ulezi se in vstani« testa pri zdravih odraslih preiskovancih ter ugotoviti povezanost izvedbe testa z antropometričnimi spremenljivkami. Metode: V raziskavo je bilo vključenih 30 prebivalcev Občine Bohinj, starih med 18 in 65 leti, med njimi 15 žensk in 15 moških. Test smo izvedli dvakrat z vmesnim 48-urnim premorom. Ponovljivost in zanesljivost testa smo izračunali s pomočjo intraklasnega korelacijskega koeficienta, standardne napake meritev ter najmanjše zaznane spremembe. Povezanost izvedbe testa z antropometričnimi spremenljivkami smo preverjali s Pearsonovim korelacijskim koeficientom. Rezultati: Povprečni čas treh ponovitev za izvedbo testa je znašal 4,7 sekunde v prvi seji in 4,9 sekunde v drugi seji. Ponovljivost je bila odlična, saj je intraklasni koeficient korelacije znašal 0,986 (IZ95% =0,975-0,993) v prvi seji in 0,990 (IZ95%=0,982-0,995) v drugi seji. Prav tako je bila odlična zanesljivost. Intaklasni koeficient korelacije je bil 0,989 (IZ95% =0,977-0,995). Standardna napaka merjenja je znašala 0,45 sekunde, najmanjša zaznana sprememba pa 1,24 sekunde. Ugotovili smo dobro povezanost izvedbe testa s starostjo preiskovancev in zmerno povezanost izvedbe testa z indeksom telesne mase in obsegom pasu preiskovancev. Sklep: »Ulezi se in vstani« test ima odlično ponovljivost in zanesljivost, zato ga priporočamo za ocenjevanje funkcijske zmogljivosti zdravih odraslih. Najprimernejši izračun izida je povprečje treh ponovitev. Potrebno bi bilo raziskati še veljavnost testa. Introduction: Timed “Lay down and get up” test was designed to evaluate functional capacity of healthy adults. Purpose: The purpose of the study was to determine repeatability and reliability of the timed »Lay down and get up« test in healthy adult subjects and to determine correlation between performance of the test with anthropometric variables. Methods: Thirty adults aged between 18 and 65 years (15 woman and 15 men) living in Bohinj municipality comprised the study sample. The test was performed twice with 48-hour break. Repeatability and reliability of the »Lay down and get up« test were calculated using intraclass correlation coefficient, standard error of measurement and the minimum detectable change. The correlation of the performance of the test with anthropometric variables was verified by Pearson's correlation coefficient. Results: The average time of three repetitions to perform the test was 4.7 seconds in the first session and 4.9 seconds in the second session. Repeatability was excellent, as the intraclass correlation coefficient was 0.986 (CI95%= 0,975-0,993) in the first session and 0.990 (CI95% = 0,982-0,995) in the second session. Reliability was excellent as well, as the intraclass correlation coefficient was 0.989 (CI95%= 0,977-0,995). Standard error of measurement was 0.45s and minimum detectable change was 1.24s. Good correlation was found between the performance of the test and the age of subjects and moderate correlation was found between the performance of the test and body mass index and the belt circumference of the subjects. Discussion and conclusion: »Lay down – get up« test is a clinical test with excellent repeatability and reliability. Therefore we recommend the test to evaluate functional capacity of healthy adults. The most appropriate calculation of the outcome is taking the average time of three repetitions into account. Validity still needs to be researched.

Varnost je del vsakdanjega življenja vseh prebivalcev, ampak se jih tega včasih zaradi hitrega tempa življenja premalo zaveda, zato so ustanove, institucije in določeni organi, ki skrbijo za vsakodnevno varnost ljudi in okolja, v katerem se živi. Cilj diplomskega dela je predstavitev delovanja Mestnega redarstva občine Slovenska Bistrica. Velik korak naprej za omenjeno občino je bilo leto 2012, saj se je sprejetjem Odloka o ustanovitvi Medobčinskega inšpektorata in redarstva občin Slovenska Bistrica, Poljčane in Makole ustanovila skupna občinska uprava za opravljanje nalog občinske uprave na področju občinskega redarstva ter inšpekcije. Prelomnica redarstva nasploh v Sloveniji je bilo leto 2006 s sprejetjem ZORed, saj so le-ti postali prekrškovni organ, večala so se pooblastila in prav tako področja dela. Velik napredek v mestni občini Slovenska Bistrica se zasledi po letu 1998, ko je bil sprejet zakon o varnosti o cestnem prometu, saj se je po sprejetem zakonu začel kazati razvoj in napredek redarstva. Prelomnica te občine je bilo leto 2015, ko je bila mestna občina Slovenska Bistrica nagrajena za najbolj varno mesto v Sloveniji. V nadaljevanju diplomskega dela je zaslediti poglavja o metodoloških pristopih mestnem/občinskem redarstvu zgodovini redarstva delovni obleki redarjev pooblastilih in nalogah redarjev zakonih ter pravilnikih, povezanih z delom mestnega redarstva mestnem redarstvu občine Slovenska Bistrica in opredelitev pridobljenih informacij. Informacije so bile pridobljene iz ankete, v kateri se je poizvedovalo, kako so občani zadovoljni s kakovostjo dela mestnih redarjev v mestni občini ter kako varno se v njej počutijo. Ugotovljeni so bili pozitivni rezultati. Security is part of everyday in our lifes, but somethimes we don't put enough attention to it, so therefor we have communitys, law enforcers and authorities to provide the security for us and the enoviroment we live. The contant of this diploma paper is the introduction of the working of the Warden of the Municipality of Slovenska Bistrica. A big step forward for this Municipality was the year 2012 when they have accepted the decree of establishment intermunicipal inspectorate and Warden of the Municipality Slovenska Bistrica, Poljčane and Makole, the mentioned Municipalities had established common munisipal managment, for operating the tasks of municipal administration on the area of municipality traffic wardens and inspections. Turning point of the municipal security was the implementation of the so called ZORed(Act on local police) from 2006 onwards, as the municipal security became minor offence authority its authorisation and field of work increased. A big progress for Municipality of Slovenska Bistrica was after the implmentation of the Road Traffic Safety Act in year 1998. the year that leave a very possitive mark was in 2015 when the Municioality of Slovenska Bistrica calimed a reward for the best secured city in Slovenia. Further in this diploma paper you can find marked points such as Methodological approach, city/municipal authorities, history and working outfits of traffic wardens, authorizations and tasks of traffic wardens, laws and rules connected to the work of municipality of traffic wardens, city constanbulary of municipality of Slovenska Bistrica and definition of gained informations. The obtained informations which are connected to the questions, are the citizens satisfied with the quality of work that traffic wardens are doing, and how safe are they in the municipality of Slovenska Bistrica. The findings showed very possitive resaults.

Glavna tema diplomskega projekta so procesi in digitalizacija podjetja. Osredotočili smo se na proces digitalizacije v podjetju, ki zajema spremembo papirnatih dokumentov v digitalno obliko, da jo lahko urejamo s pomočjo računalnika. Zarisali smo tudi proces, s pomočjo katerega lahko uvedemo različne tehnologije in pripomoremo k še bolj digitalno podprtemu sistemu. To pripomore k boljšemu delovanju in poslovanju organizacije. Zarisali smo proces digitalizacije in idejo o procesu digitalne transformacije za uporabo v delovanju in poslovanju podjetja. Opredelili smo Industrijo 4.0, na kateri temelji ideja o digitalni transformaciji. Za tako velik projekt imajo podjetja možnost uporabe zunanjega izvajalca, zato bomo omenili projektiranje in s tem povezane zadeve. V vsakem primeru je smiselno narediti elaborat, ki bo pripomogel k boljši izvedbi. S pomočjo elaborata želimo predstaviti slabosti v delovnem procesu in kako se jim izogniti. Diplomski projekt je namenjen analizi in prikazu obstoječega delovnega procesa uvedbe digitalne tehnologije s poudarkom na organizacijski in procesni podpori. V izdelavi diplomske naloge želimo raziskati pomanjkljivosti in zastoje pri procesu ter ugotoviti sodobne načine. Namen tega dela je oblikovanje zasnove procesa digitalizacije, ki se bo začela z idejo o uvedbi digitalne tehnologije in končala z realizacijo te. Želimo predstaviti potek procesa digitalizacije in tudi zaris tega. Predstavili bomo značilnosti Industrije 4.0 in tehnologij v njej. Raziskovanje tega diplomskega projekta se bo pretežno osredotočalo na preučevanje procesov in organizacijskih modelov ter ugotavljanje praks s tega področja. Spoznanja in ugotovitve bomo primerjali in kombinirali, da dosežemo uporaben model za prakso. Uporabili smo deskriptivno metodo, ki se uporablja za opisovanje dejstev. S to metodo bomo preučevali pomen besed Industrija 4.0, digitalizacija, digitalna transformacija, procesi, modeliranje in projektiranje. Na koncu bomo spoznali vpliv digitalne tehnologije na organizacijo, zaris procesa in pomen procesa digitalizacije za podjetje. Ugotovili smo, da digitalizacija pripomore k izboljšavi delovanja in poslovanja podjetja in da je to univerzalno uporaben proces, namenjen vsem podjetjem. The main topic of the diploma project is the processes in digitization. We focused on the process of digitization in a company, which involves the conversion of paper documents into digital form, so that it can be edited using a computer. We have outlined a process model of digitization and the idea of a digital transformation process for business use. We defined Industry 4.0, on which the idea of digital transformation is based. For such a large project, companies have the opportunity to use an outsource resources, so we will mention project planning. In any case if a company does it themselves or with help of other company, it makes sense to make a project elaborate, that will help to better perform. Using the study we wish to present the weaknesses in the work process and how to avoid them. The graduate project is intended for the analysis and presentation of the existing working process of digitization, the introduction of digital technology, with emphasis on organizational and process support. In preparing the diploma thesis, we want to investigate the shortcomings and delays in the process, and to find out modern ways of solving them. The theses will determine whether digitization helps improve business performance and is a universally applicable process for all companies. The purpose of this work is to design the concept of the digitization process, which will begin with the idea of introducing digital technology and end with its realization. We want to present the course of the digitization process and also the drawing of this. We will also present the characteristics of the industry 4.0 and technology in it. The research of this diploma project will mainly focus on the study of processes in organizational models and the identification of practices in this field. Findings will be compared and combined to achieve a useful model. We used the descriptive method used to describe the facts. With this method we will study the meaning of the words Industry 4.0, digitization, digital transformation, processes, modeling and design. In the end, we will determine the impact of digital technology on the organization, the process and the significance of the digitization process for the company.

Organizacije morajo danes svoje družbeno odgovorno ravnanje upravičiti deležnikom skozi prikaz ustvarjene vrednosti zanje in poročanje predstavlja eno od glavnih orodij komuniciranja, s katerim to dosežejo. Tradicionalna poročila ne dosegajo več potreb deležnikov, zato se je razvil nov koncept celovitega poročanja, ki na jedrnat način podaja holističen pogled na organizacijo. Magistrsko delo preučuje, katere prednosti organizaciji in njenim deležnikom prinaša celovito poročanje v primerjavi s tradicionalnim poročanjem. Raziskava je razdeljena na dva dela, in sicer na analizo vsebine izbranih letnih poročil slovenskih organizacij, kjer ugotavljamo, katere elemente celovitega poročanja je mogoče najti v letnih poročilih. Drugi del raziskave pa skozi polstrukturirane intervjuje s tremi skupinami deležnikov – lastniki podjetij, finančno javnostjo in vodstvom podjetja – raziskuje s strani deležnikov zaznane prednosti celovitega poročanja. Ugotovitve raziskave so pokazale, da poročila slovenskih organizacij obsežno vsebujejo tri elemente CP: »predstavitev organizacije in zunanjega okolja, v katerem deluje«, »strategij[o] in razporeditev virov za uresničevanje strateških ciljev« in »uspešnost poslovanja«, deležniki pa zaznavajo poglavitno prednost predvsem v bistvenosti poročanih informacij in prihodnjem vidiku poslovanja podjetja. Nowadays, organizations have to justify their socially responsible behaviour to their stakeholders by showing them how they are creating value for them. One of the main communication tools to achieve that is reporting. Traditional reports no longer meet the needs of stakeholders therefore, new concept called integrated reporting has been developed. It offers a concise and more holistic view of an organization. This master thesis examines the benefits for the organization and its stakeholders that integrated reporting delivers compared to traditional reporting. The research is divided into two parts. The first part is the content analysis of the annual reports of selected Slovenian organizations, where we want to determine which elements of integrated reporting can be found in annual reports. The second part of the research consists of semi-structured interviews with three groups of stakeholders: business owners, financial community and business management. It explores the benefits of integrated reporting perceived by stakeholders. The findings are that reports of Slovenian organizations extensively contain three elements of IR: “organizational overview and external environment”, “strategy and resource allocation” and “performance”. Benefits perceived by stakeholders are materiality of reported information and future orientation of the reports.

Olimpijsko dviganje uteži je samostojen olimpijski šport, pri katerem dvigalci uteži tekmujejo v dveh disciplinah: v potegu in sunku. Poteg je disciplina, pri kateri dvigalec dvigne ročko od tal nad glavo v enem neprekinjenem gibu s širokim prijemom. Pri potegu prihaja do delovanja različnih sil bodisi na olimpijsko ročko bodisi na naše telo. V naši raziskavi smo se odločili, da si podrobno ogledamo navpično komponento sile reakcije podlage, ki deluje nasprotno od dvigalčevega potiska v tla po 3. Newtonovem zakonu. Namen dela je bilo primerjati silo reakcije podlage pri potegu pri boljših in slabših dvigalcih. Pri tem smo si izbrali breme 80 % 1 RM potega. Opazovali smo obliko grafa in različne parametre. Rezultati večinoma potrjujejo dva različna tipa krivulje, ki sta značilna za boljši in slabši tip dvigalca. Značilne razlike med skupinama smo opazili pri sili prvega vrha prvega vlečenja in tretjega vrha drugega vlečenja glede na telesno težo dvigalca. Pri povprečnem naklonu prvega vlečenja smo opazili statistično značilne razlike, medtem ko pri najbolj pričakovanih razlikah pri drugem vlečenju ni bilo značilnih razlik. Takšno obliko analize priporočamo trenerjem olimpijskega dviganja, saj lahko z grafom sile reakcije podlage pojasnjujejo šibke in močne odseke dviga pri vsakem dvigalcu posebej. Iz obliki grafa je namreč dobro razvidno, kje so pomanjkljivosti. Olympic weightlifting is a stand-alone Olympic sport where lifters compete in two exercises: snatch and clean and jerk. The snatch is a discipline in which the lifter lifts the bar from the ground above the head in one single motion with a wide grip. In the course of the process there are various forces acting either on the weightliting bar or on our body. In our study we decided to observe the vertical component of the ground reaction force which works opposite of the lifter's thrust into the ground according to the 3rd Newton law. The purpose of this master thesis was to compare ground reaction force of two different groups of lifters based on experince: good and bad. In this case we selected the load of 80% of 1RM. We observed a differentiation according to the shape of the graph and various parameters. The results are confirmed mainly by two different types of curves which are typical for better and worse type of lifters. Significant differences between groups were observed in the first peak of the first pull and the third peak of the second pull based on total force and bodyweight ratio. At the average inclination of force development of the first pull, statistically significent differences were observed while the most expected differences in the second pull did not have any significant differences. We recommend this type of analysis to the olympic lifters as they can explain the weak and strong sections within each lift based on ground reation force. Based on shape of the graph we can point out techincal anomalies of the specifc lifter.

Diplomsko delo Razmerje med sliko in fotografijo analizira dve umetniški smeri, fotografiranje in slikarstvo. Natančneje predstavim nastanek oziroma razvoj fotografije in njen vpliv na slikarstvo. V nadaljevanju opišem tudi razvoj slikarstva, pri čemer se ne morem izogniti vprašanju, kakšno je ob tem razmerje med fotografijo in nastalo sliko. Zanimalo me je, kako so slikarji sprejeli nastanek novega medija, ali je to, tako v preteklosti kot sedanjosti,vplivalo na njihovo delo oziroma kako so fotografi sprejemali po nastanku starejšo umetniško smer. Natančneje sem analizirala tudi razvoj upodabljanja akta, ki je že vse od začetka obeh umetniških smeri ena najpogosteje upodobljenih tem. Za boljše razumevanje razmerja med fotografijo in sliko izpostavljam tudi nekatere vidnejše predstavnike likovne umetnosti, ki so se pri slikanju spogledovali s fotografijo predvsem ženskega akta. V zadnjem delu naloge na podlagi teoretičnih osnov predstavljam primer uporabe fotografije akta kot predloge za nastanek slike z akrilnimi barvami. The thesis The ratio between painting and photography analyzes two artistic directions, photography and painting. I look closer to the formation or development of photography and its impact to painting. In continue i also write about dvelopement of painting, where we can not avoid the question of how it is the ratio between photography and created painting. I was interested in how painters accepted invention of new medium , and if this infected their work in the past just like in the present, or how the photographers were accepting that older artistic direction. More precisely, i also analyzed the formation of rendering act, which was all from the begining, of both artistic directions, one of the most common depicted themes. For better understanding of ratio between photography and painting i exposed some of more visible representatives of fine arts, who used a photography in their paintings, especially female act. In the last part of thesis, on the basis of theoretical basics, i present an example of use photography of act, as templates for formation of painting with acrylics.

Upamo, da bo priročnik postal tvoj zvesti spremljevalec in pomočnik. Najprej za načrtovanje, nato pa tudi za uporabo kakšne od opisanih strategij.

Izbrano podjetje se ukvarja s prodajo izdelkov spalnega programa. Ponujajo širok spekter potrebščin za ves dom. Zaradi proizvodnje v tujini imajo pri nas nekakšno distribucijsko skladišče, od koder opravljajo odpremo za potrebo polnjenja lastnih trgovin, sodelovanja z veleprodajalci ter spletna naročila. Pri skladiščenju se podjetje srečuje s določenimi težavami. Trenutno skladišče nima določenih primernih površin za odlaganje palet ob razkladanju tovornega vozila, ki izdelke dostavlja. Težave jim povzroča tudi ujemanje zalog z dejanskim stanjem zaradi človeških napak pri odpremi in lociranju. Z uvedbo določenih sprememb, ki smo jih predlagali v diplomskem delu, bi občutno izboljšali vse procese v skladišču. V končni fazi bi podjetju prihranili denar in čas, ki ga trenutno izgublja po nepotrebnem. The selected company deals with the sale of products for sleeping. They are offering a wide variety of products for housing. Because of the abroad production warehouse in Slovenija is ment just for distribution. From this warehouse they carry out the dispatch for the needs of filling their own stores, completing orders for wholesalesmans and to complete oneline orders. Company occasionally comes acrosse some warehousing problems. One of the problems is that they do not have a suitable place to offload palets that are delivered to them with a delivery. Many times the problem is that inventory on computer does not match with the actual state on the location due to human errors in the dispatch and locating of products. With the introduction of specific changes that we proposed we could significantly improve warehousing operations.In the end effect we would prevent a lot of unnecessary time and money consumption that the company is currently losing.