1. [Pharmaco-toxicologic evaluation of newly synthesized analogs of propafenone].
- Author
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Tumová I, Racanská E, Csöllei J, Ecker G, Otrusník R, and Svec P
- Subjects
- Adrenergic beta-Agonists therapeutic use, Adrenergic beta-Agonists toxicity, Anesthetics, Local, Animals, Anti-Arrhythmia Agents toxicity, Arrhythmias, Cardiac chemically induced, Guinea Pigs, Isoproterenol, Propafenone therapeutic use, Propafenone toxicity, Anti-Arrhythmia Agents therapeutic use, Arrhythmias, Cardiac drug therapy, Propafenone analogs & derivatives
- Abstract
The basic pharmacological evaluation of five analogues of propafenone was the aim of the present paper. Antiarrhythmic activity of the compounds at 10(-5) mol.kg-1 was established in guinea-pigs using experimental arrhythmias induced by ouabain and aconitine. The beta-adrenolytic efficiency of the compounds was studied in the isolated spontaneously beating guinea-pig atria and expressed as pA2 values against isoprenaline tachycardia. All of the compounds studied were local-anaesthetically active and their indexes of efficiency were 1-5 fold higher in comparison with the standards cocaine and procaine. The acute toxicity of the compounds was within acceptable limits.
- Published
- 1997