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Introduction/Objective. The aim of our paper was to investigate the clinical efficacy of using a phentolamine alcohol wet dressing to treat the extravasation of an intravenously administered infusion of milk fat. This study was designed as a randomized trial, and was done at the Hengshui people’s Hospital, Hebei Province, China, from June 2019 to June 2020. Methods. In total, 300 patients were randomly divided into two groups. In the experimental group, the patients were treated using a phentolamine alcohol wet dressing, whereas in the control group, the patients were treated using a hydropathic compress with a 50% magnesium sulphate solution. The cure rate, healing time, and patient satisfaction of the two groups were compared and analyzed. Results. The cure rate of intravenous infusion extravasation was 92.67% (139/150) in the experimental group and 70.67% (106/150) in the control group (p < 0.05). In the experimental group, there were 66 patients whose cure time was less than 24 hours, 62 patients whose cure time was between 24 and 48 hours, and 22 patients whose cure time was over 48 hours. The cure time of the patients was significantly shorter in the experimental group than the control group. After treatment, in the experimental group, 67 patients were very satisfied, 52 patients were satisfied, 21 patients were generally satisfied, and 10 patients were dissatisfied; in the control group, 32 patients were very satisfied, 40 patients were satisfied, 56 patients were generally satisfied, and 22 patients were dissatisfied. The satisfaction of patients was significantly higher in the experimental group than in the control group. Conclusion. The effect of using a phentolamine alcohol wet dressing to treat the extravasation of an intravenous infusion of milk fat is significantly better than the effect of using a magnesium sulphate solution, and this type of dressing is worthy of clinical application.