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2 results on '"Rutonjski Laza"'

1. Left breast radiotherapy – the impact of heart and left anterior descending artery doses to cardiovascular diseases developed eight years after treatment

Author

Petrović Borislava, Petrović Milovan, Đuran Branislav, Đan Igor, Miljković Tatjana, Čanković Milenko, Pesznyak Csilla, Rutonjski Laza, and Ivanov Olivera

Subjects
cardiotoxicity, computer-assisted radiotherapy planning, left-sided breast cancer, radiotherapy, Medicine
Abstract

Introduction/Objective Left breast cancer patients undergoing radiotherapy are at higher risk of cardiovascular diseases (CVD), as a partial volume of the heart is anatomically close to target volume. This may cause CVD in the years following cancer treatment. The aim of this work was to develop a scoring system which identifies patients with increased risk of development of CVD, as a consequence of the left breast irradiation. Methods The patients followed up in this study were treated during 2009. Eight years later, they were invited to participate in a study where they underwent a cardiology evaluation. Their current condition was statistically correlated to the doses received by their heart and left anterior descendant artery (LAD). Results Out of 114 patients, 31 women were evaluable for cardiology assessment. Out of these 31 subjects, six women were with a history of CVD before cancer treatment. Four women never developed any kind of heart associated disease, while in the other 27, newly onset CVD were diagnosed ranging from hypertension to myocardial infarction, strongly positively correlated to doses to heart and LAD (p = 0.003). Severity of developed cardiovascular toxicity was formulated through the correlation of mean heart and mean LAD doses with CVD developed in the form of a scoring system. Conclusion The doses to critical organs depend on patient anatomy and technique of irradiation. The cardiovascular complications are proven as consequence of radiotherapy. Scoring system based on doses received by heart and LAD is a reliable tool in predicting CVD.

Published
2022
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2. Quality assurance in radiotherapy - verificationof treatment planning system and clinicalimplementation of in vivo dosimetry

Author

Rutonjski, Laza, Petrović, Borislava, Todorović, Nataša, Klisurić, Olivera, Erak, Marko, and Ciraj, Bjelac Olivera

Subjects
kontrola kvaliteta u radioterapiji, sistem zaplaniranje, in vivo dozimetrija, quality control in radiotherapy, treatmentplanning system, in vivo dosimetry
Abstract

Predmet istraživanja ove doktorske disertacijeje osiguranje kvaliteta u radioterapiji. U okvirurada na disertaciji je sprovedena kliničkaverifikacija sistema za planiranje terapije uvedim radioterapijskim centrima u Srbiji saciljem obezbeđivanja optimalnog korišdenjaTPS i bezbedne radioterapije. Ova verifikacijapredstavlja bitan deo QA radioterapijskogprocesa, gde se nakon početne verifikacijeprikupljeni podaci koriste i za dalje periodičneprovere u okviru osiguranja kvaliteta. Daljeistraživanje je sprovedeno u ciljuimplementacije in vivo dozimetrije u kliničkupraksu kao veoma bitne procedure zaosiguranje kvaliteta čitavog radioterapijskogprocesa, od preskripcije do isporuke doze. Nataj način su određeni nivoi tolerancije/akcije zarazličite grupe pacijenata i određeneradioterapijske tehnike. Takođe, procenjena jetačnost radioterapijskog procesa na Institutu zaonkologiju Vojvodine u Sremskoj Kamenici., The subject of this dissertation is qualityassurance (QA) in radiotherapy. As part of thethesis was conducted clinical verification oftreatment planning systems (TPS) in majorradiotherapy centers in Serbia in order toensure the optimal usage of TPS and saferadiotherapy. This TPS verification is animportant part of radiotherapy QA process,where after an initial verification of the datacollected and then used for further periodicchecks as part of quality assurance. Furtherresearch was conducted in order to implementin vivo dosimetry in clinical practice as a veryimportant procedure for quality assurance ofthe entire radiotherapy process, fromprescription to dose delivery. In this way,tolerance/actions levels for different groups ofpatients and specific radiation technique weredetermined. Also, the accuracy of theradiotherapy process at the Institute ofoncology of Vojvodina in Sremska Kamenicawas estimated.

Published
2015

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