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The synthesis and metabolism of lipids and lipoproteins are regulated by a number of hormones, among which are prolactine and growth hormone. The levels of triglycerides, total cholesterol and LDL, although within normal range, were higher in hypeprolactinemia than after the therapy with dopamine agonists in hypeprolactinemic females. This is confirmed by the results of our research and other studies. The changes of total, LDL and non HDL-cholesterol were significant. No significant differences in the level of HDL-cholesterol was confirmed. The mechanisms of the onset of this disturbance has not yet been explained. Recent studies suggest that prolactin has not only the indirect, but also the direct impact on metabolism of lipids and lipoproteins. Acromegaly is also associated with a higher prevalence of a disbalanced metabolism of lipids and lipoproteins. The hypersecretion of GH is often associated with hypertriglyceridaemia. The levels of total cholesterol and HDL cholesterol were normal, higher or lower in these studies. The LDL cholesterol showed higher levels. The level of lipoprotein (a), apoprotein (A, E) were higher in 30% of the patients with acromegaly. The hypersecretion of GH and PRL can increase cardiovascular risk due to their association with disturbances of lipid metabolism.