Background. The COVID-19 pandemic and the mass self-isolation associated with it had a significant impact on the features of the semantic sphere of personality formed by students at its beginning. And the more the changed living conditions affected the life and health of the students themselves, the more likely their life-meaning orientations, basic beliefs, as well as the practice of filling the time of their own life have changed. It is important to determine what differences in these parameters are observed in those students who have had this viral infection, when compared with those students who have not had it. The purpose of the study was to identify the features of the meaning-of-life orientations of the individual, basic beliefs and the daily structuring of life time during the period of self-isolation of students who were ill with the COVID-2019 viral infection. Materials and methods. The sample consisted of 180 students who studied at the 4th year of several Moscow universities (MSPPU, RSSU, MSOU, etc.) at the faculties of social and humanitarian orientation. A group of students who had been ill with COVID-19 was selected from this randomly compiled student sample. Two student groups were compared: 1) students who have had COVID-19; 2) students who have not had it. Empirical data are collected on the basis of the test “Life orientations” by D.A. Leontiev, the scale of basic beliefs (WAS) by R. Yanov-Bulman in the adaptation of M.A. Padun and A.V. Kotelnikova and a specially developed methodology for students ‘ self-assessment of the structure and volume of daily employment during the period of restrictive measures related to the COVID-19 pandemic. The list of types of daily employment was developed by students of the 4th year of the Faculty of Extreme Psychology of the Moscow State Psychological and Pedagogical University during training sessions in an online format. It included the following types of daily employment: sleep, educational activities, housework, time at the computer for non-educational purposes, lying in a horizontal position, maintaining physical fitness, watching TV, other employment-its own version, which could include work, volunteer activities, etc. The students participating in the study were given instructions as subjects: “Please remember what exactly you were usually busy with during the day during the period of self-isolation and express it in % ratio, based on the total amount of 100%. In the line: “Other employment” – list what exactly you were doing.” Mathematical and statistical data processing is carried out on the basis of the MS package Office Excel, IBM SPSS Statistics 23. The reliability of the differences in the indicators of the two student groups was determined by the Mann-Whitney U-criterion. Results. It is established that ill virus COVID-19 students differ from students without a history of them, the higher the overall level of meaningfulness of life; although the structure of the General level of meaningfulness of life in them is the same (in first place is the goal of life, followed by: locus of control life, the process of life, the result of life; this completes the hierarchy of locus of control, “I”), but the students had been ill with the virus COVID-19, live with a more pronounced sense of the efficiency of life and are more motivated people; they also have a relatively higher indicators of locus of control life, the process of life, locus of control “I”; ill with the virus COVID-19 students have similar levels of belief in the benevolence of the world and control the events in their life events without a history of them students. At the same time in their cognitive models of the world was formed more than a high, but not beyond the normative values, the level of basic beliefs – in their own luck and luck, the value and significance of their own “I”, there is justice; students who recover from the virus COVID-19, more varied structure of his employment during the day, compared to without a history of them students. Conclusion. The data obtained empirically confirm the presence of differences between the student samples: students who have had the COVID-19 virus infection differ from their peers who have not had it, both by the peculiarities of the semantic sphere of the individual and by the peculiarities of structuring the time of their own life. In order to scientifically explain these identified differences, additional research is required with a large coverage of students.