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Start Over Descriptor "rab GTP-Binding Proteins metabolism" Language russian
1 results on '"rab GTP-Binding Proteins metabolism"'

1. [Multiadaptor 4.1 and RanBP9 protein family members as putative interaction partners for VARP, a Rab21 GTPase guanine nucleotide exchange factor].

Author

Pal'gova IV, Korobko EV, and Korobko IV

Subjects
Adaptor Proteins, Signal Transducing, Animals, Gene Library, Humans, Mice, Protein Binding, Two-Hybrid System Techniques, Cytoskeletal Proteins metabolism, Guanine Nucleotide Exchange Factors metabolism, Membrane Proteins metabolism, Nuclear Proteins metabolism, rab GTP-Binding Proteins metabolism, ran GTP-Binding Protein metabolism
Abstract

VARP is a novel VPS9 domain-containing protein which acts as a guanine nucleotide exchange factor for small GTPases Rab21 and Rab5, regulators of early endocytosis. However, the molecular mechanisms underlying VARP activity regulation and intracellular localization remain unknown. Using protein interaction cloning in yeast we isolated multiadaptor proteins of 4.1 protein family and RanBP9 as putative VARP interaction partners. The interactions revealed might be important for proper intracellular localization of VARP and its functions in early endocytosis.

Published
2007

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