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The high incidence of persistent periapical infection in the lateral group of teeth is one of the problems of modern dentistry. The purpose of our study was to determine the reasons for preserving the periapical focus of infection after conservative treatment and to identify ways of solving this problem. The analysis of domestic and foreign literature on this subject is carried out. An original questionnaire for dentists was developed, according to which 127 doctors were interviewed. Also explored 187 intraoral radiographs of first and second molars of the mandible and presented three clinical observations. Due to the high frequencies in the region of one of the root mandibular molars localization of the pathological process, conservative and surgical therapy is method of elimination chronic periapical infection. The effectiveness of treatment depends not only on the qualifications of the doctor, but also on the patient’s responsible attitude to the recommendations, in particular to comply with their terms of prosthetics.

The aim of this study was to investigate the changes of thyroid-stimulating hormone and thyroid hormones concentrations in blood of rats with lateral hemisection of spinal cord before and after injection of ultra-low doses of hypothalamic neuropeptide galarmin. Studies showed a sharp increase of thyroid-stimulating hormone level in rats with hemisection of spinal cord and an appreciable drop in the level of thyroid hormones in blood.and a sharp drop in the level of thyroid hormones in the blood. The action of ultra-low doses of galarmin decreased the concentration of thyroid-stimulating hormone and simultaneously increased the level of thyroid hormones which is typical for the intact animals. [ABSTRACT FROM AUTHOR]