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Purpose: analysis of epidemiological, clinical and laboratory features of imported malaria in the North-Western Federal district (NWFD) in 2012–2016. Research materials: the study included 84 patients treated for malaria in the hospitals of the NWFD. Results: 84 cases of malaria were registered in the NWFD from 2012 to 2016, which constituted 18,9% of all cases registered inRussian Federation(n=445):St. Petersburg(n=60),Arkhangelsk(n=10),Murmansk(n=5),Leningradregion (n=4),Vologdaregion (n=2) and 1 case in Komi,NovgorodandKaliningradregion. Patients with malaria had a history of a recent visit to: Asian countries (37%, n=31), West Africa (35%, n=30), North Africa (11%, n=7),South Africa(8%, n=7), East and Central Africa (3% correspondingly),Dominican Republic,CubaandSouth America(1% correspondingly). Pl. vivax was most common cause of malaria in patients visited Asia (87%), while recent travel to West Africa predispose patients to malaria caused by Pl. vivax in 37%, Pl. falciparum in 57% and Pl. оvale in 6% of all cases. All patients arrived from the North, South, Central Africa andDominican Republichad malaria caused by Pl. falciparum. Conclusion: in NWFD in 2012-2016 in the process of providing care to patients with malaria the following trends were marked: late referral of patients for medical care, careless collection of epidemiological data and travel history, late diagnosis of the disease, insufficient supply of antimalarial drugs and severe malaria in patients with comorbidity. Lack of adequate therapy with modern drugs has led to the lethal cases in patients with tropical malaria and the occurrence of late relapses of tertian malaria.

Malaria in the Republic of Guinea is the main cause of morbidity and lethality. It takes the first place in number of all visits in medical service (30–40%) and is the main cause of hospital death. One records annually more than 8 millions malaria cases, and about 60 000 children deaths. Results of study of immune response changing on different disease phases in treatment of autochthon population and immune status of Europeans are presented. It was shown that immunity status (cellular and humoral) in population of Guinea (an endemic country on falciparum malaria) differs from one in Europeans living in tropics. During light forms of malaria one records an increase of T-lymphocyte and IgG number, whereas in grave cases one observed the acute decrease of these indices. The essential increase of B-lymphocyte number does not depends from gravity of disease and from malaria treatment. It was established that appearance of LSA1-41 antibodies was in a more degree in adult patients than in children. The positive correlation between IgM and IgG was established in adult patients as in children.