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Start Over Descriptor "allergoid" Language russian
2 results on '"allergoid"'

1. New forms of home dust mite allergoid

Author

V. M. Berzhets, A. A. Babakhin, N. S. Petrova, A. V. Vasileva, S. V. Khlgatyan, and O. Yu. Emelyanova

Subjects
allergenic extract, home dust mite allergens, allergenspecific immunotherapy, formalinization succinilation, allergoid, allergenicity, immunogenicity, Microbiology, QR1-502
Abstract

Aim. The purpose of this study is to create the technology of preparation of the polymeric allergoid received by chemical modification of Dermatophagoides farinae extract by a formaldehyde and a monomeric allergoid of Dermatophagoides pteronyssinus received by succinilation and studying of their physical, chemical and immunologic properties.Materials and methods. In the modification species determined the protein content, isoelectric points of protein components by a method of isoelectrofocusing (IEF), esterase activity. Antigenic properties of allergoid studied by methods of an immunodiffusion and an immunoelectrophoresis. Applied microdot immunoenzyme assay to characterize the specific activity of a resulting allergoid. Received by a succinilation allergoid was also studied on physical and chemical indicators.Results. It is established That the formalinization is resulted by the expressed depression of allergenic activity of an allergoid. It is also shown that succinilation leads to essential depression of allergenicity of a monomeric allergoid due to blockade of B-cellular epitopes and to conservation of an adjuvanticity helps to T-cellular epitopes.Conclusion. Thanks to the proved depression of allergenicity and rising of an adjuvanticity monomeric and polymeric allergoid can be recommended for carrying out allergenspecific immunotherapy (ASIT).

Published
2019
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2. CLINICAL AND IMMUNOLOGICAL EFFECTIVENESS OF TREATMENT OF RAGWEED POLLINOSIS IN THE SAMARA REGION

Author

M. V. Manzhos, L. R. Khabibulina, E. Yu. Syrtsova, and N.N. Zhukova

Subjects
Ragweed, medicine.medical_specialty, medicine.medical_treatment, Immunology, medicine.disease_cause, Gastroenterology, il-4, Allergen, Internal medicine, Immunology and Allergy, Medicine, amb a 1, ragweed, Sensitization, Ambrosia artemisiifolia, Asthma, biology, pollinosis, business.industry, trifida, Immunotherapy, RC581-607, biology.organism_classification, medicine.disease, cytokines, Allergoid, medicine.anatomical_structure, Ambrosia trifida, immunotherapy, Immunologic diseases. Allergy, business
Abstract

Allergic rhinitis and bronchial asthma are widespread respiratory allergic diseases. In some territories of the Russian Federation, the dominant cause of pollinosis is ragweed. The aim of the study was to evaluate the clinical and immunological efficacy of ASIT with the allergen Ambrosia artemisiifolia in patients sensitized to Ambrosia trifida in the Samara region. Patients with proven sensitization to Ambrosia trifida was held immunotherapy with Ambrosia artemisiifolia allergoid preseason. After treatment, patients had a decrease in the severity of symptoms of allergic rhinitis according to VAS (p = 0.00001), a decrease in the need for medications (p = 0.0003), as well as the need for corticosteroids against the background of therapy from 34.6% to 0% (p = 0.00001). In 8% of cases, the result of treatment was good, in 69% satisfactory, in 23% unsatisfactory. In the control group, there were no changes in the severity of symptoms (p = 0.858). Also, in the control group, the need for medications remained unchanged and 14.3% of patients continued to use corticosteroids.After ASIT, there was a decrease in the level of IL-4 (p = 0.002), and a decrease in the ratio of IL-4/ IL-10 (p = 0.0063); at the same time, changes in the level of other cytokines (IL-10; IFNγ) were statistically insignificant (p > 0.05). Before treatment, the levels of IL-4/ IL-10 in both groups were comparable, and after treatment, the differences became statistically significant (p = 0.031). We did not get a statistically significant change in the level of IgG4 Amb a 1 or IgG4 Amb trifida. There was no correlation between the level of individual cytokines and the results of treatment. As a result of the conducted ASIT, positive clinical and immunological results were obtained. In most patients, the disease has acquired a controlled course. At the same time, the lack of excellent and low number of good results of ASIT is probably due to the intraspecific allergenic properties of ragweed.

Published
2021

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