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Introduction. The article focuses on reconstructing the major parameters of the complex of challenges and threats to post-Soviet Central Asia regional security that has emerged in the wake of or in direct connection with the radical change of the situation in Afghanistan after August 2021. These challenges and threats have developed across several functional and territorial dimensions and require a comprehensive analysis followed by the building of scenarios for their evolution. Methods and materials. The research relies on the regional security complex theory developed by Barry Buzan and Ole Waever. The methodological toolkit includes external indirect observation, political descriptive and historical genetic methods, scenario building. The research materials include official statements, news briefs, expert opinions, periodicals, academic papers. Analysis. The authors have analyzed the geostrategic, regional-strategic, regional-economic, and regional-societal dimensions of the challenges and threats to Central Asian regional security generated by the changes in Afghanistan and have built scenarios of their evolution. The major geostrategic challenge is the exacerbation of U.S. – Chinese contradictions centered on the influence of the Taliban factions. The key regional-strategic threat is the risk of the Afghan conflict spilling over into Tajikistan or Turkmenistan. The regional-economic challenges include the risks of blocking trans-Afghan transport, pipeline, and electricity transmission projects. The regional-societal risks consist of the dissemination of radical Islamist ideologies from Afghanistan throughout Central Asia. The two basic scenarios of the regional security evolution are inertia or a resumption of a full-scale civil war in Afghanistan. Results. The authors have worked out sets of recommendations for regional policymakers and the intergovernmental bodies whose functions include maintaining security and stability in Central Asia. Authors’ contribution. A.E. Dzhorobekova has developed the general concept of the article and organized the research. E.F. Troitskiy has focused on the analysis of threats and challenges to regional security. S.M. Yun has developed scenarios for regional security situations. A.G. Timoshenko has formulated the relevant recommendations.

Стаття розглядає тематику кулінарних культурологічних кодів в китайській і українській мовах. Предмет нашого дослідження представляє найважливіші для китайців і українців концептуальні поняття рис та хліб. Здебільшого в нашій статті ці поняття розглядаються у фразеологізмах та ідіомах, оскільки вони є частиною мови, яка в свою чергу є чи не найголовнішим фактором існування будь-якого народу, його культури та менталітету. Концепти рис та хліб у цій статті досліджуються на мовному матеріалі прислів’їв і приказок у двох мовах – китайській та українській. Актуальність статті полягає в зіставленні висловів протилежно різних культур за принципом схожості їх посилу та змісту. Нами було проведено лінгвістичний аналіз, який, з культурологічної точки зору, розширив уявлення про місце таких суттєво концептуальних стрижнів у тій області, як рис і хліб, і загалом роль аналізованих кулінарних концептуальних лексем у культурі Китаю в порівнянні з їх сприйняттям українцями.

Background. The article is devoted to an analytical review of the methods of using stem cells in the treatment of diabetes mellitus (DM). Aim: to analyze, based on the data of the literature, the prospects of using stem cells for the treatment of DM. Materials and methods. Review of scientific literature in the international electronic scientometric databases PubMed, Scopus, Web of Science by keywords for the period 20017-2023. The search was carried out by three independent authors. 98 sources were selected for analysis, of which 33 were used that met the search criteria. Results. DM is a serious problem for the health care system worldwide, which requires the development of new innovative and effective therapeutic approaches. The use of stem cells is one such promising strategy for solving this problem. The ability of stem cells to differentiate into various body cells, including beta cells of the pancreas, was analyzed. Animal studies have demonstrated the ability to improve insulin synthesis and lower blood glucose levels. The use of stem cells in the treatment of DM is not a widespread approach and requires additional clinical studies. General information on the use of stem cells in the treatment of diabetes is presented and the prospects of this method of therapy are outlined. Conclusions. The use of stem cells in the treatment of diabetes is a promising technology that may open new opportunities for the treatment of this disease. However, more research needs to be done, a number of technical, ethical, and legal issues need to be addressed, as well as regulatory standards for the production and use of stem cells.

Sarcopenia is characterized by a progressive loss of muscle mass, strength, and function, leading to poor outcomes and reduced quality of life. In middle age, the decrease in muscle mass begins to be progressive. Bioimpedancemetry allows diagnosing this condition before the onset of clinical symptoms. The purpose of the study: to evaluate the parameters of body composition in the early diagnosis of sarcopenia in middle-aged people. Materials and Methods: The participants were divided into two groups the main one with sarcopenia 146 people and the control group 75 people. The complex of examinations included: neuropsychological testing (Hospital Anxiety and Depression Scale (HADS), quality of life questionnaire for patients with sarcopenia (SarQoL), short health assessment form (SF-36)), 4-meter walking speed test, dynamometry and bioimpedancemetry. The results of neuropsychological examination did not differ in the main and control groups. Patients with sarcopenia showed a decrease in muscle strength according to dynamometry. The scores of the walking speed assessment test in the study group were significantly higher than in the control group. The main and control groups had excessive body weight. According to the results of bioimpedanceometry, the main group had increased fat mass, percentage of fat mass, visceral fat area, and fat mass index compared with the control group. Skeletal muscle mass was less in the main group, probable sarcopenia was confirmed by decreased appendicular mass, decreased protein and mineral content was also recorded. There was a more pronounced decrease in cell mass in the main group. In patients with sarcopenia the volume of intracellular and extracellular fluid was less than in the control group. Significant differences were considered at p0.05. Conclusions: the introduction of bioimpedancemetry and dynamometry into early screening for muscle mass reduction will allow timely start of therapeutic and preventive measures even in middle age, which will lead to a decrease in the progression of sarcopenia in the elderly, as well as improve the quality of life.

Modern Uzbekistan undergoes wide-scale social and economic reforms that include the modernization of higher education system. This paper aims at evaluating the actual and potential impact of the reforms in Uzbekistan’s higher education on the Russian universities’ opportunities to export education to Uzbekistan. Accordingly, the paper traces the evolution of the national higher education system under President Islam A. Karimov (from 1991 to 2016), analyzes the new priorities of higher education policies set by his successor Shavkat M. Mirziyoyev, shows their interlinkages with the transition to a new model of national development, and focuses on the objectives and instruments of higher education internationalization. Theoretically and methodologically, the research relies on the concepts of internal and external internationalization of higher education, Clark’s model of higher education system elements, and Trow’s concept of higher education massification levels. The authors show the scale and interconnectedness of higher education challenges that have been developing in Uzbekistan in the course of the 25 years of its independence. The authors argue that higher education internationalization has become a way to achieve a number of objectives, in particular to improve the quality of higher education, orient it to massification, make it more accessible in the country’s regional centers. The paper shows the parameters of internal and external internationalization of higher education in Uzbekistan that has demonstrated the unprecedented dynamics in post-Soviet countries. The paper underlines that the policy of rapprochement with Russia launched by Tashkent in 2016 has created exceptionally beneficial opportunities for Russian universities to work in Uzbekistan and attract Uzbek students. Four mid-term scenarios of higher education internationalization in Uzbekistan are suggested.

The aim of the work is to increase the effectiveness of physical therapy of motor impairments in children with spastic form of cerebral palsy by applying a program of therapeutic training on the device developed for rehabilitation of people with musculoskeletal disorders. Materials and methods. 30 children aged 6 to 11 years with cerebral palsy-associated spastic diplegia were included in the study. Patients were divided into 2 groups. In addition to the standard rehabilitation program, all patients were prescribed therapeutic gait training using a device for rehabilitation of people with musculoskeletal disorders: group I (n = 14) – according to the dynamic method; group II (n = 16) – by static method. The spatiotemporal characteristics of gait, activity daily indicators, the level of spasticity of lower extremity muscles, functional characteristics of gait, and the methods of mathematical statistics were studied. Results. The implementation of the elaborated program of therapeutic exercises using a device for rehabilitation of people with musculoskeletal disorders had a positive effect on the level of muscle spasticity of the lower extremity, stride length, walking speed, general endurance. It also improved balance and reduced the risk of falling in children with cerebral palsy. Conclusions. The application of the elaborated therapeutic program had a positive effect on the spatiotemporal characteristics of walking, balance and functional condition of children with cerebral palsy, as well as reduced the level of spasticity. The increase in the stride length occurs during the first 4 weeks of training, and functional condition indicators showed the greatest dynamics only after 6 weeks of training. The elaboration of the rehabilitation device with the ability to move and apply the technique of exercising with partially unstable pelvic support by the abductor-lift moving along the vertical axis, positively affected the balance and reduced the risk of falling.

Introduction. Kidney cancer remains an urgent problem in modern oncology. More than 200 thousand new cases of kidney cancer are diagnosed globally every year, with about 100 thousand patients dying. 15–17% of patients are diagnosed with stage IV kidney cancer. Arterial tumour embolization and nephrectomy are used as a palliative treatment.Aim. To evaluate the results of renal artery embolization in combined treatment of stage IV kidney cancer.Material and methods. The treatment results of 22 patients with stage IV kidney cancer are presented: 6 patients had metastases in the skeletal bones; 15 — metastases in the lungs; 1 — bilateral kidney damage. At the first stage, all patients underwent renal artery embolization. Subsequently, 6 patients received bisphosphonates and radiation therapy for metastases in the skeletal bones, 15 patients underwent operation followed by a targeted therapy with Sunitinib and Sorafenib), 1 patient with bilateral kidney damage underwent operation followed by a 2-year targeted therapy with Sorafenib.Results and discussion. Renal artery embolization was performed successfully without technical difficulties in all the patients. After embolization, hemostasis was achieved in all patients with hematuria (n = 14). Postembolization syndrome was noted in 13 patients with total renal artery embolization. 6 patients with metastases in the skeletal bones lived for 16.4 ± 2.1 months, the survival time of 15 patients who received renal artery embolization, nephrectomy and targeted therapy was 41.7 ± 15.3 months. Only one patient (bilateral kidney damage) has been under dynamic observation for the period of 10 years.Conclusion. Renal artery embolization is an effective and minimally invasive technical procedure that should be used in the combined treatment of patients with kidney cancer. The combined use of renal artery embolization and subsequent targeted therapy for kidney cancer provide new opportunities for stage IV combined treatment.

IntroductionRegardless an improgressive habit of neural disorders in cerebral palsy (CP), without a therapy the motor abnormalities’ severity rising is registered and as a result with age the physical dysfunction progressively increases.PurposeTo improve the static and dynamic motor disorders’ and activity limitations physiotherapy efficiency among the children with hemiplegic CP form via the therapeutic training program on the developed device for rehabilitation of the people with muscle-skeleton disorder.Material and methods 24 children with unilateral CP aged from 6 to 11 were enrolled into the research. The patients were randomized into 2 groups. Additionally to the standard physiotherapy complex the I group were prescribed with the walking trainings on the rehabilitation device according to the dynamic method, the II group – according to the static method. Physiotherapy program duration was 6 weeks. The gait spatiotemporal characteristics and activity limitations were monitored.Results Appling developed program influenced on the walking spatiotemporal indexes in the both groups. The biggest increase of the distance and stride length were reached exactly on the 2 week. Herewith, distance incremental amount in the I group was higher than in the II study group. TUG test’s time decreased statistically efficiently in the I group. Maximum TUG test’s index depression was observed on the 6th study weeks. As a result GMFM-66 increased in I group.Conclusions An administration of the developed therapeutic program affected positively on the CP patients’ spatiotemporal walking characteristics, balance and endurance, as a result, decreased the fall risk and activity limitations.

Presently, cardiovascular diseases (CVD) hold the leadership positions not only in terms of prevalence, but also in the mortality structure all over the world. The incidence of CVD increases with age and accounts for more than 50% among the population over 70 years old in Russia. As it is known, old age is characterized by polymorbidity, and all concomitant conditions change the clinical picture, course, and prognosis of CVD. Anemic syndrome is one of the aggravating factors of CVD, particularly in the case of iron deficiency. Anemia is also an important problem of health service practices, as it affects the quality of life, mortality and is a common reason for seeking medical advice. The literature analysis shows that anemia is an independent predictor of cardiovascular disease and adverse outcomes. Due to the fact that the incidence rate of anemia increases with age, it makes it a frequent concomitant pathology of cardiovascular accidents. The increase in sympathetic activity and cardiac output due to prolonged hypoxia-induced vasodilation, which results in left ventricular hypertrophy and an increase in the size of the heart and, accordingly, in the increased oxygen consumption seems to be the mechanism of the pathology. Also, decreased myocardial tolerance to low hemoglobin levels is observed in patients with coronary artery disease as compared with healthy subjects. Therefore, patients need to pass a comprehensive examination, including the mandatory measurement and monitoring of hemoglobin levels. Primary measures should be aimed at eliminating the etiological factor that causes anemia of varying severity. Oral and intravenous iron drugs, as well as erythropoietin drugs should be used as the main therapy.Despite the effective diagnosis and treatment regimens designed for the treatment of these diseases, and a wide range of effective drugs, problems in this area remain the most urgent.

Cardiovascular diseases (CVD) is the most frequent cause of death in diabetes mellitus (DM) patients, and diabetes, in turn, significantly increases the risk of cardiovascular pathology, and therefore the implementation of measures for primary and secondary prevention of complications in patients with DM and CVD is a topical direction of modern medicine. In case of diabetes, CVDs occur 2-5 times more frequently than in persons without this pathology. There is also a high risk of developing conditions such as coronary heart disease (CHD), myocardial infarction (MI), arterial hypertension (AH), acute cerebrovascular disease (ACVD). Thus, 69% of patients with DM have dyslipidemia, 80% - AH, 50-75% - diastolic dysfunction, 12-22% - chronic heart failure (CHF). Mortality from MI among patients with DM is 1.5-2 times higher than among people who do not suffer from this disease, both in the acute stage of MI, and in prolonged observation. Therefore, it is necessary to work out a common approach to this problem on behalf of both cardiologists and endocrinologists, and patients, which will improve the quality of treatment and prevent the development of DM complications.Intensive control of glycemia in patients is essential to prevent the development and progression of DM complications, which is proved by a number of fundamental studies presented in this article. Regular and competent self-control by patients allows maintaining normal or close to normal blood glucose levels. It is a reliable, convenient and patient-friendly way to prevent the development of diabetic complications.

Статья посвящена сравнению пословиц в трех языках (русском, сербском и китайском) на основе многоязычного словаря М.Ю. Котовой «Русско-славянский словарь пословиц с английскими соответствиями». В результате данного анализа сопоставляются языковые картины мира трех наций. Объектом исследования выступает пословица как лингвокультурологический феномен, предметом – пословицы о судьбе в русском, сербском и китайском языках. В исследовании выявляются общие черты русских, сербских и китайских пословиц о судьбе (тематическая группа «Судьба), а также указывается на их различия. В работе дается определение пословицы, рассматриваемой в качестве объекта исследования в трех языках; сравниваются русские пословицы о судьбе с их пословичными параллелями в сербском и китайском языках. В статье исследуются полные пословичные параллели, пословичные параллели с другой внутренней формой (аналоги) и лакуны.

Despite our achievements in modern medicine, arterial hypertension (AH) remains one of the main causes of fatal complications, such as myocardial infarction and acute cerebrovascular accident leading to disability and mortality of patients, including those of working age. The prevalence of hypertension is significantly higher among old and senile age population, however, it has recently tended to increase in young and middle-aged people. Thus, the Russian epidemiological ESSE-RF study, in which representative sample of the Russian population aged 25–64 years were studied, showed that the prevalence of hypertension in individuals of that age group was 44%. It was predicted that the world’s burden of hypertension would increase by 15–20% to approximately 1.5 million people in the year 2015. Due to the high incidence of hypertension and complications associated with hypertension development, further study of pathogenetic mechanisms, development of diagnostic examination methods, prophylactic measures and the search for new treatment options with fixed-dose combination drugs is an important area of modern medicine. This article provides an overview of clinical studies of the components (lisinopril and indapamide) of a rational ACE inhibitor–diuretic combination and a clinical example.

Introduction. The relevance of this study is determined by the gradual expansion of contacts between the PRC and the Russian Federation in the educational sphere and the need to improve the national education systems. The purpose of the article is to identify methodological problems in organizing Sino-Russian educational programs for training engineers for the People’s Republic of China and to propose the optimal solution to these problems. Materials and Methods. In considering the problems of organization of the educational process for joint Sino-Russian educational programs, we use empirical methods: description, content analysis, comparison and synthesis. A survey of teaching staff and students was conducted. Students and teachers, who took part in the joint program of Saint Petersburg Electrotechnical University and Xuzhou University of Technology were selected to be interviewed. The survey also involved teaching staff and students of Jiangsu Pedagogical University. Results. We will suggest recommendations for the development of joint programs, the purpose of which is to prepare highly qualified engineers for the People’s Republic of China. These recommendations will improve the educational process, the quality of the professional training of Chinese students, enhance their level of proficiency in the Russian language. Our results suggest that to improve the quality of training of Chinese engineers who receive two diplomas, it is necessary to take into account the motives of Chinese students, their cognitive style of learning, the used learning strategies and the national characteristics of the Chinese education system. Discussion and Conclusion. The results of this study may be useful to educators involved in collaboration activities between educational institutions of different countries. Following the proposed recommendations, we expect teachers in special subjects to easily write textbooks, including digital ones that suit the topical students’ needs and enable teaching staf f efficiency.

Resonant states (quasi-intrinsic functions) play an important role in the scattering problem and in the description of transportprocesses. We consider the system completeness of resonance states on a finite subgraph for quantum graphs with both finite and infinite edges. The Schrodinger operator acts on the graph edges. The relationship of the scattering problem with the Szőkefalvi-Nagy functional model is taken into account. In particular, the scattering matrix is a characteristic function of the functional model, and the question of the system completeness of resonant states is reduced to factorization type determining of the characteristic function on the Blaschke product and the singular internal function. This fact makes it possible to use an effective sign of a singular factor absence in the decomposition of the characteristic function for the proof of completeness (incompleteness) available in the functional model. The system incompleteness of resonance states for a "ring-type" graph connected to a waveguide at one point (initial graph) is proved. The dependence of the system completeness of resonant states on initial graph geometry changes is studied.

The CVD death rates remain high now. The concurrent course of coronary artery disease (CAD) and diabetes mellitus (DM) has an unfavourable prognosis, requires specific therapy and the use of measures to prevent severe complications. DM sometimes hinders the timely diagnosis of CAD, which in this case is characterized by an atypical course and has no florid symptoms. This often causes serious pathological complications or death. The atherothrombosis forms the basis of pathogenesis of severe conditions. Atherothrombosis is not only a generalized, but also a constantly progressive disease, for which reason it is necessary to carry out both primary and secondary prevention. According to the existing guidelines of European Society of Cardiology and Society of Cardiology of Russian Federation, acetylsalicylic acid (ASA) is recommended at small doses as the first-line drug for the prevention of vascular events in patients with CAD. This article discusses the experience of using ASA according to the conducted studies and in practical medicine by the clinical example of a female patient.

This article discusses clinicopharmacological niches of fosinopril, one of the most popular ACE inhibitors in daily outpatient practice. The authors cover aspects, where fosinopril has advantages over other ACE inhibitors and angiotensin II receptor blockers (sartans) from the point of view of therapy, cardiology and clinical pharmacology. The theses taken as a basis of the article are confirmed by the authors, who named and reviewed the leading clinical trials of fosinopril and its potentially possible combinations with diuretics and calcium channel blockers. The article also covers issues and satellite phenomena of “vascular” comorbidity in patients with arterial hypertension, chronic heart failure and chronic kidney disease; describes the mechanisms of their development and mutual aggravation; examines the points of administration and the evidence for the efficacy and safety of fosinopril in this cohort of patients. One of the main theses of this article is the importance of organ-protection (-cardio, -nefro, -angio). The main directions and postulates of its implementation are provided using the example of ACE inhibitors.

This paper draws upon unpublished letters from Charles Eliot Norton to Henry James regarding James’s visit to the Bethnal Green Museum in London; and considers the similarities and divergences between James’s review, “The Bethnal Green Museum,” published in the Atlantic Monthly in 1873, and a comparable review of Norton’s “The Manchester Art Exhibition,” published in the same magazine some two decades earlier.

The author of the article notes that the legal culture determines the level of legal knowledge, legal understanding and legitimacy. The article considers the peculiarities of the formation of the legal culture of the reign of Peter the Great. Attention is paid to causality and factors affecting the quality and condition of the legal consciousness and legal culture of the period under study looked through in the historical and legal context. The researcher concluded that the reforms of Peter I significantly changed the content of the legal culture of Russian society, primarily due to the increasing role of legislation and politics.

This article is devoted to actual problem of cardiology – cerebrovascular complications of hypertension in the form of transient ischemic attack (TIA). TIAS are predictors of stroke, irreversible brain disorders. In order to prevent irreversible pathology will require further analyze the possible aspects that cause complications cerebrovascular in nature in hypertensive patients.

Данная статья посвящена актуальной проблеме кардиологии – оптимизации диагностического подхода к больным гипертонической болезнью (ГБ), осложненной цереброваскулярной патологией в виде транзиторных ишемических атак (ТИА). Определена патогенетическая роль окислительного стресса в развитии ТИА при ГБ. В статье представлены данные о диагностической значимости метода определения карбонильных групп белков как о новом тесте по определению продуктов окисления белков у больных ГБ с вероятностью возникновения ТИА.

The stick­slip process of bending faults with one angle change of 5° at the connection location between the two line fault segments is investigated in this paper. The dynamic process and physical field evolution were observed in the laboratory, and measurements were recorded with application of fault displacement measurement, strain tensor analysis and acoustic emission (AE) techniques. The experimental results from the study of bending faults give grounds for the following primary conclusions: (1) It is clearly revealed that there is a negative correlation between the logarithms of the stick­slip cycle and loading rate; (2) With different loading rates, most of the instabilities from bending faults occurred as earthquake doublets. It means that an instable event can contains two sub­events which occur with an interval of time from 100 ms to 200 ms. (3) With application of different observation approaches, regardless of the fact that the sampling rates were the same, differences of the co­seismic response were observed. For instance, strain measurements indicated significant strain weakening stage, but fault displacement was not significantly changed before fault instability. (4) Experimental studies of high sampling rates contribute to a better understanding and awareness of earthquake precursors and the seismogenic process; such studies are helpful in analyzing the mechanism of strong earthquake processes and parameters of aftershocks.

Among many cytoprotective drugs, only a few of them that have a targeted metabolic effect include agents that partially inhibit oxidation of free fatty acids, the so-called p-FOX inhibitors (partial fatty acid oxidation inhibitors). Aim. To develop a procedure for the preventive use of meldonium dihydrate in day-hospital patients with comorbidity. Subjects and methods. The investigation enrolled 189 patients (116 men and 73 women; mean age, 55.9±4.4 years) who were followed up for initial manifestations of cardiovascular and/or another somatic disease and were at high risk for unfavorable cardio- and cerebrovascular events, as well as complications of emergency alcohol-related conditions. The investigation of the efficacy and safety of meldonium dihydrate was planned as an open-label clinical trial in three parallel groups different in the directivity patterns of potential complications («Cardio», «Cerebro», «Alco»). The drug’s dosage averaged 500 to 1000 mg/day. Results. The day-hospital use of meldonium dihydrate demonstrated high safety profile and a positive role in the prevention of cardio- and cerebrovascular catastrophes and complications of emergency alcohol-related conditions and chronic alcoholic visceropathy, leading to delayed dyslipidemia progression, diminished insulin resistance, improved blood rheological properties, and suppressed chronic systemic inflammation and also proving its role in the prevention of renal vascular injury and toxic (ethanol) encephalopathy. Meldonium therapy showed positive effects in delaying the progression of dyslipidemia, diminishing insulin resistance, improving blood rheological properties, and suppressing chronic systemic inflammation and also proved its role in preventing renal vascular injury and toxic (ethanol) encephalopathy, which confirmed the versatility of the cytoprotective effect of meldonium. Conclusion. The drug has proved to be effective and safe in hemodynamic, electrolytic, hepatic, and other parameters, which makes it expedient to include meldonium in the day-hospital formulary of drugs for a preventive parenteral cycle according to the developed regimen (a 10-day cycle at least 1—2 times a year) for patients at high risk for social diseases and their complications.

Abstract: Germany, Great Britain and France stated their interests in Central Asia immediately after the disintegration of USSR. In 1994 and 1995 the policies of the leading European countries towards Central Asia stressed the restraining of Russia’s neo-imperial ambitions in the post-soviet space and the support of economic independence of Central Asian states. As of late 1990s the regional policies prioritized fighting the drug threat and after September 11, 2001 — the terrorism threat. The article reveals specific interests and country priorities of the leading European states in Central Asia and the differences in the general approach to the region and in the actual policies including the amounts of resources spent. The author argues that Germany occupies the most solid place in Central Asia due to a set of political, economic, military and humanitarian interests, though in general the regional policies of Germany, Great Britain and France lack any particular interests and standpoints, that could hinder the formation of the joint EU policy in the region.

The article tells about the etiology and pathogenesis of iron deficiency, clinical manifestations and principles of treatment of iron deficiency anemia. The choice of drug therapy is highlighted. The advantages of non-ionic iron preparations (Maltofer) for patients with iron deficiency anemia are provided.

This article examines the modern approach to the treatment of arterial hypertension as one of the most important medical and social problems in the developed world, characterised by a high prevalence high risk of cardiovascular complications and occurrence along with comorbid diseases.

One of the major challenges in the modern medicine is chronic heart failure (CHF) characterized by high incidence, really unfavourable prognosis and high cost of treatment.

This report examines interest in compounds that normally prevent the toxic effects of ROS -antioxidants, namely reduced ubiquinone, which is only lipid soluble antioxidant synthesized in cells of animals and humans, and continuously recovered from oxidized form by enzyme systems of the body, to possibilities of the use of coenzyme Q10 in cardiovascular diseases, has a beneficial therapeutic effect on the body, resulting in improvement of the cardiovascular, immune system, significant improvement in rehabilitation period, a significant increase in body energy, the use of coenzyme Q10, including in pediatric cardiology and study its effectiveness in primary and secondary mitochondrial defects as a means of adjuvant therapy of diseases and pathological conditions, as vegetative dystonia, diabetic kardioneyropatiya, myocardial dystrophy, hypertension, metabolic syndrome, cardiomyopathy posthypoxic newborn, chronic pulmonary heart, hyperlipidemia, the recovery period after cardiac correction of congenital heart disease, minimally invasive correction of arrhythmias and pacemaker implantation, etc. reperfusion syndrome, ischemia, hypertension, heart disease, aging, childhood.

This study examined the originality of psychologism in the novel «We» written by E. Zamyatin in the context of Nonclassical Prose. In the novel, E. Zamyatin connected social and psychological point of view not refusing gains of realism of 19th century. In addition, he showed protagonist's outside world as well as introspection simultaneously. Psychological basis of this study is K. Jung's theory.

Цель. Изучить правильное ведение больных с высоким риском сердечно-сосудистых осложнений сравнительно простых мероприятий, одним из которых является использование препаратов с доказанной эффективностью и в правильных дозах.При проведении гипотензивной терапии следует учитывать, что иногда сложно достичь уровня систолического артериального давления (АД) до 130-139/80-89 мм рт. ст. у пациентов с сахарным диабетом, поражениями органов-мишеней, у пожилых больных и людей, имеющих сердечно-сосудистые осложнения.В российских и международных рекомендациях по лечению артериальной гипертензии (АГ) в качестве приоритетных для лечения АГ у больных, перенесших острый инфаркт миокарда, острое нарушение мозгового кровообращения, а также пациентов с заболеваниями почек, сахарным диабетом и метаболическим синдромом выделяют препараты группы ингибиторов ангиотензинпревращающего фермента (ИАПФ). Одним из наиболее эффективных препаратов группы ИАПФ является периндоприл аргинин (Престариум А). Сердечно-сосудистые эффекты ингибирования АПФ с помощью периндоприла (Престариума) и его благоприятное влияние на прогноз были доказаны в крупнейших международных клинических исследованиях: EUROPA (PERTINENT, PERSPECTIVE, PERFECT), ПРЕМИЯ и др. Последнее время особое внимание обращают на себя фиксированные комбинации дигидропиридинов с ИАПФ продленного действия - комбинация Престанс (амлодипин + периндоприл аргинин). Эта комбинация позволяет использовать одновременно положительные свойства двух современных антигипертензивных средств с внушительной доказательной базой в плане эффективности. Престанс - это принципиально новый антигипертензивный препарат, который уже успешно применяется в 34 странах. Престанс имеет целый ряд преимуществ в виде эффективного снижения АД (на 42/23 мм рт. ст. через 60 дней лечения). Это объясняется синергизмом действия двух мощных антигипертензивных компонентов, периндоприла аргинина и амлодипина, и реальным 24-часовым контролем АД.Выводы. Комбинация Престанс (амлодипин + периндоприл аргинин) максимально снижает риск развития сердечно-сосудистых осложнений и смерти от них. Помимо снижения АД до целевого уровня необходимы коррекция терапии и в лечении ассоциированных и сопутствующих заболеваний, замедление темпа прогрессирования поражения органов-мишеней и соблюдение профилактических мер.