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In May 2022, Saudi Arabian Military Industries, a Saudi government agency, acquired an augmented reality training platform for pilots. In September, the Boeing Corporation began the development of an augmented reality pilot simulator. In November, a similar project was launched by BAE Systems, a leading British developer of aeronautical engineering. These facts allow us to confidently speak about the beginning of a new era of aviation simulators – simulators using the augmented reality technology. One of the promising advantages of this technology is the ability to safely simulate dangerous situations in the real world. A necessary condition for using this advantage is to ensure the visual coherence of augmented reality scenes: virtual objects must be indistinguishable from real ones. All the global IT leaders consider augmented reality as the subsequent surge of radical changes in digital electronics, so visual coherence is becoming a key issue for the future of IT, and in aerospace applications, visual coherence has already acquired practical significance. The Russian Federation lags far behind in studying the problems of visual coherence in general and for augmented reality flight simulators in particular: at the time of publication the authors managed to find only two papers on the subject in the Russian research space, while abroad their number is already approximately a thousand. The purpose of this review article is to create conditions for solving the problem. Visual coherence depends on many factors: lighting, color tone, shadows from virtual objects on real ones, mutual reflections, textures of virtual surfaces, optical aberrations, convergence and accommodation, etc. The article reviews the publications devoted to methods for assessing the conditions of illumination and color tone of a real scene and transferring them to virtual objects using various probes and by individual images, as well as by rendering virtual objects in augmented reality scenes, using neural networks.

Background. Mantle cell lymphoma (MCL) is a rare and clinically aggressive lymphoma subtype. Current approaches have greatly improved patients outcomes, but relapse is inevitable. In phase IIIII clinical trials, ibrutinib has shown significant activity in patients with relapsed or refractory (R/R) MCL. Aim. To assess efficacy and toxicity of ibrutinib monotherapy in patients with R/R MCL in routine practice outside of clinical trials. Materials and methods. The study enrolled patients with confirmed R/R MCL who had received at least one line of previous chemotherapy. ECOG 24, cytopenia, infectious complications, hemorrhagic syndrome were not exclusion criteria. Patients received daily oral ibrutinib 560 mg until progression or unacceptable toxicity. Results. From May 2015 to September 2020 ibrutinib therapy was started in 106 patients with R/R MCL in 16 regions of Russia. The median age was 66 years; ECOG2 18%, blastoid variant (or Ki6740% or WBC50109/l) 43%. The median number of previous treatment lines was 2 (111). The ORR was 78.4% (CRR 27.4%). The median PFS was 13.6 months and OS 23.2 months. In the blastoid group the median PFS was 4.4 months vs 36.5 months in the alternative group (p0.001), the median OS 9.0 vs 41.0 (p=0.001). The median OS of patients after progression on ibrutinib was 3.2 months. The common complications are hemorrhages (63%), diarrhea (62%), myalgia and muscle cramps (60%), infections (31%), skin and nail toxicity 15%, arrhythmia 8%. None of recipients had to completely discontinue ibrutinib therapy due to complications. Conclusion. Ibrutinib is effective and well tolerated in routine practice of R/R MCL treatment and our results are consistent with international clinical trials. The favorable toxicity profile and the high response rate made it possible to prescribe ibrutinib in severe somatic status, cytopenia, and even in the presence of infectious complications.

Biodiversity is closely related to human health and ecological environment. It has become very important due to its influence on the economic and political strategies of various countries. Fungal diversity is an important part of biodiversity and is of great significance in maintaining the balance of ecosystems. On the basis of fungal diversity studies the innovative conservation system “One district, one herbarium and five banks” was proposed and later applied on Qinghai-Tibet Plateau. In order to protect important fungal resources a conservation district of Yajiang Matsutake Reserve was established in Sichuan Province. To preserve the species, genetics and local natural fungal resources, the herbarium, the spawn bank, the viable tissue bank, the gene bank, the compound bank, and the comprehensive information bank were created, which resulted in the systematic protection of fungal diversity on Qinghai-Tibet Plateau and provided support for the sustainable use of fungi. Innovation and integration of the protection system of fungal resources and key technologies for sustainable utilization not only restore the ecological environment of important wild Fungal resources but also screen and cultivate new varieties of edible and medicinal fungi It has been promoted and demonstrated and gave significant ecological, social and economic benefits.