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The object of the article is a non-descriptive lexeme. Its use is investigated in various semantic-syntactic and communicativepragmatic contexts. The relevance of the work is due to the need for amore holistic description of a number of primitive linguistic units (a, and, either, or, etc.), the categorical properties of which are not fully and systematically identified within the framework of traditional methods of analysis. The novelty of the work lies in the consideration of all uses within the framework of the functioning of the lexeme-particular of the same name. This approach is due to the principles of nonparadigmatic linguistics — a modern trend in the study of primitive lexemes. The theoretical significance of the work lies in the introduction into scientific circulation of the principles of the analysis of a particular li based on its ancient categorical properties associated with the semantics of conjecture. It has been established that in all the considered contexts we are dealing with the same particular lexeme, which retains its original categorical properties in them. They are manifested in the questioningness of li (direct or indirect), as well as in various hypothetical meanings that are realized in sentences-statements at a deep syntactic level. Asimilar description technique is applicable to the analysis of the properties of other particular units of the Russian language.

TWIK-related acid-sensitive potassium channel-1 (TASK-1) is a "leak" potassium channel sensitive to extracellular protons. It contributes to setting the resting potential in mammalian neurons. TASK-1 channels are widely expressed in respiratory-related neurons in the central nervous system. Inhibition of TASK-1 by extracellular acidosis can depolarize and increase the excitability of these cells. Here we describe the distribution of TASK-1 in the rat brainstem and show that TASK-1 mRNAs are present in respiratory-related nuclei in the ventrolateral medulla, which have been proposed as neural substrates for central chemo-reception in rats. After inhalation of 8% CO2 for 30 and 60 min, TASK-1 mRNA levels in positive-expression neurons were remarkably upregulated. Injection of the TASK-1 blocker anandamide (AEA) into the rat lateral cerebral ventricle, showed a significant excitement of respiratory at 10 min posttreatment, with a marked decrease in inspiratory and expiratory durations and an increased frequency of respiration. We suggest that TASK-1 channel may serve as a chemosensor for in central respiration and may contribute to pH-sensitive respiratory effects. TASK-1 channel might be an attractive candidate for sensing H^(+)/CO2 in several respiratory-related nuclei in the brainstem. It is likely that TASK-1 participates in pH-sensitive chemical regulation in the respiratory center under physiological and pathological conditions.