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Diabetes is an established risk factor for periodontitis. We investigated AGEs distribution in human gingival tissues and monocyte cytokine expression in diabetic patients with chronic periodontitis (DII/ cP). Within indicated surgical procedures gingival biopsies were taken from 10 DII/cP and from 10 healthy controls. Tissue samples were prepared for immunohistochemistry using a monoclonal antibody specific for AGEs (6D12, TransGenic Inc.) and IMAGES J was used for quantification. Mean clinical parameters in DII/cP presented typical for severe chronic periodontitis (mt: 10.5; BoP: 84%; PBI: 2.9; cAL: 5.5 mm; rAL: 6.9 mm). In gingival tissue from DII/cP immunohistochemistry showed enhanced accumulation of AGEs (17%) compared to controls (13%). This study found that diabetes and periodontitis results in further AGE-accumulation compared to periodontitis alone. These results suggest the possibility that the blockade of RAGE may provide an effective approach in a range of diabetic complications including periodontal disease.

For three-dimensional reconstruction of defects of the alveolar crest to the conduct of dental implantation today use autogenous blocks grafts from the iliac crest, the pubic symphysis or branches of the lower jaw. The authors evaluate the regeneration potential of the soft tissues of the sky as a new source of stem cells in combination with transplantation of osteoplastic material for building bones and delayed implantation. Developed the method of treatment showed the ability of the bone marrow, stem and progenitor cells for the regeneration of various tissues, including bone.